Jianhao Lin

The LiaFSR-SpxA2 regulatory axis governs bile salt resistance and virulence in Group B Streptococcus

Lınhong Wang, Ruoyu Li, Jianhao Lin, Fengyang Li et autres

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), colonizes the intestinal tract, where it must overcome bile salt-mediated membrane disruption to establish infection. However, the specific molecular mechanisms underlying this resistance remain unclear. In this study, a Himar1 transposon screen identified …

The LiaFSR-SpxA2 regulatory axis governs bile salt resistance and virulence in group B Streptococcus

Lınhong Wang, Ruoyu Li, Jianhao Lin, Fengyang Li et autres

Streptococcus agalactiae, also known as Group B Streptococcus (GBS), colonizes the intestinal tract, where it must overcome bile salt-mediated membrane disruption to establish infection. However, it is unclear the specific molecular mechanisms underlying this resistance. In this study, a Himar1 transposon screen …

The LiaFSR-SpxA2 regulatory axis governs bile salt resistance and virulence in Group B Streptococcus

Linhong Wang, Ruoyu Li, Jianhao Lin, Fengyang Li et autres

transcription in response to bile salt stress, defining a novel LiaFSR-SpxA2 regulatory pathway playing a role in bile salt resistance in GBS. Importantly, this LiaFSR-SpxA2 regulatory axis plays a role in colonization and virulence in a tilapia infection model. Collectively, our work …

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Multidimensional Characteristics of Musculoskeletal Pain and Risk of Falls Among Elderly Adults: The Cross‐Sectional Evidence From CHARLS

Fengyao Mei, Jiao Jiao Li, Jianhao Lin, Shengjie Dong et autres

OBJECTIVE: Falls are common particularly in elderly people and usually associated with poor prognosis or healing outcomes. Musculoskeletal pain is considered an independent risk factor for falls, by being associated with joint pathology and instability, neuromuscular effects of pain, and changes in …

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Walking difficulty as a marker of high health need and education-related healthcare response in older adults: a cross-national multicohort study

Long Chen, 伍谟煊, Hui Li, Ninggang Liang et autres

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Multimorbidity Trajectories Across Three National Ageing Cohorts: Early Branching States and Persistent Cardiometabolic-Musculoskeletal Profiles

L H Chen, Senyang Xiao, Yiqi Su, Hui Li et autres

Background/Objectives: Disease count alone does not show which multimorbidity combinations diversify or persist. We examined longitudinal changes in clinically recognisable multimorbidity profiles across three national ageing cohorts. Methods: Harmonised data from the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal …

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An Rnf213-deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling

Yuanyuan Dai, Xiaoxin Wu, Shuai Li, Xingyang Niu et autres

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Weakly Aggregated Polymeric Network Enabling Advanced Hard Carbon for Sodium Storage

Jianhao Lin, Zhishan Liao, Yike Liu, Bote Zhao et autres

ABSTRACT Constructing a closed pore structure through precursor modification has been regarded as an effective route for boosting plateau capacity in hard carbon (HC) anodes for sodium‐ion batteries (SIBs). However, the mechanistic role of polymer aggregation behavior in the closed pore formation …

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Molecular alterations prediction in gliomas via an interpretable deep learning model: a multicentre and retrospective study

Chu Han, Danyi Li, Bingchao Zhao, Xi Zhang et autres

BACKGROUND: Molecular profiling of gliomas has a pivotal role in diagnosis, treatment selection, and prognostic assessment. However, it heavily relies on time-consuming and expensive genomic testing, which is largely inaccessible in resource-limited settings. To enable cost-effective and scalable identification of molecular alterations, …

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Echinacea purpurea extract enhances growth, antioxidant capacity, and intestinal integrity via the microbiota-metabolism-barrier axis to alleviate Aeromonas veronii infection in largemouth bass (Micropterus salmoides)

Jianhao Lin, Weitao Zhou, Huanhuan Jia, Huanling Xing et autres

Echinacea purpurea extract enhances growth, antioxidant capacity, and intestinal integrity via the microbiota-metabolism-barrier axis to alleviate Aeromonas veronii infection in largemouth bass (Micropterus salmoides)

Jianhao Lin, Weitao Zhou, Huanhuan Jia, Huanling Xing et autres

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Fine-Grained Differentiation-Based GNN for Auxiliary Diagnosis of Kashin-Beck Disease

Hu Li, Chendan Mu, Mengqi Li, Hui Li et autres

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