Wen‐Hua Chen

CYP2D6 as an Emerging Endogenous Oxidative Stress Modulator in Cardiovascular Disease: Genetic, Pharmacological, and Redox Perspectives

Cheng-Wu Yang, Wen‐Hua Chen, Tzong‐Shyuan Lee

Oxidative stress is a central and well-established driver of cardiovascular disease, contributing to mitochondrial dysfunction, endothelial injury, inflammatory activation, and progressive myocardial and vascular remodeling. Although the major endogenous sources of cardiovascular reactive oxygen species (ROS), including NADPH oxidases, mitochondrial electron transport …

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DNAJB4 Protects Against Atherosclerosis by Stabilizing the HSP70-LXRα Axis in Hepatic Lipid Metabolism

Wen‐Hua Chen, Chia-Hui Chen, Man‐Chen Hsu, Po-An Hu et autres

DNAJB4, a member of the DNAJ/HSP40 family, functions as a co-chaperone of HSP70, regulating protein homeostasis and cellular functions.However, the molecular mechanism underlying the biological effect of DNAJB4 on lipid metabolism remains unclear.We investigated the role of DNAJB4 and its molecular mechanism …

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Structure-Based Discovery of JN210 as a Potent Dual DCN1/HDAC Inhibitor for the Treatment of Nonsmall Cell Lung Cancer

Tao Zheng, Yigui Li, Yunyuan Huang, Linchong He et autres

Resistance to monotherapy remains a major challenge in the treatment of nonsmall cell lung cancer (NSCLC), highlighting the need for innovative therapeutic strategies. To address this issue, we developed a dual-targeting strategy aimed at simultaneously inhibiting the oncogenic protein-protein interaction (PPI) between …

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The Plant Growth Regulator Forchlorfenuron (KT-30) Drives Atherosclerosis Progression via Lipid Homeostasis Disruption: Evidence from ApoE-Deficient Mice

Chia-Hui Chen, Po-An Hu, Chun-Sheng Chuang, Wen‐Hua Chen et autres

Oxidative stress is a central driver of atherosclerosis progression, promoting lipid peroxidation, vascular inflammation, and hepatic metabolic dysfunction. Forchlorfenuron (KT-30), a cytokinin-like plant growth regulator widely used on fruits such as kiwifruit, grapes, and watermelon, has been reported to elevate serum cholesterol …

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Development of Glycosylated and Dimeric FAP-Targeted Radiotracers for Preclinical Evaluation in FAP-Positive Glioblastoma Models

Tian Jin, L Y H Sun, Chaoquan Lai, Boyu Tan et autres

Fibroblast activation protein (FAP) is an important target for tumor diagnosis and therapy. In this study, two FAP-targeted radioligands, the monomeric [ 68 Ga]Ga-DOTA-T1-FAPI and the dimeric [ 68 Ga]Ga-DOTA-T1-(FAPI) 2, were designed by introducing a glucose linker into FAPI-04 and its …

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Molecularly engineered solvatochromic fluorescent probes for the recognition of nonalcoholic steatohepatitis and inflammation by the detection of lipid droplet polarity

Jingjie Liang, Lanqing Li, Le Chen, Wen‐Hua Chen

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The Emerging Role of N-Lactoyl-Phenylalanine (Lac-Phe) in Metabolic Regulation and Disease: From Exercise-Induced Metabolite to Therapeutic Candidate

Julia Chu-Ning Hsu, Chia-Hui Chen, Ming-Wei Chen, Wen‐Hua Chen et autres

N-Lactoyl-phenylalanine (Lac-Phe), identified in 2022 as an exercise-inducible signaling metabolite, is formed by carnosine dipeptidase 2 via conjugation of lactate and phenylalanine. Its circulating levels rise sharply after intense exercise in mice, humans, and racehorses, reflecting increased glycolytic flux. Beyond exercise, Lac-Phe …

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Selective sodium-glucose cotransporter two inhibitor empagliflozin ameliorates diabetic cardiomyopathy by activating the AMPK/TFEB signaling pathway.

Man‐Chen Hsu, Ru-Wen Chang, Mu‐Chun Wang, Chia-Hui Chen et autres

The highly selective SGLT2 inhibitor (SGLT2i) is reported to have beneficial effects on diabetic cardiac hypertrophy; however, the molecular mechanisms underlying the cardioprotection of SGLT2i are not fully understood. In this study, we investigated the impact of the SGLT2 Inhibitor empagliflozin (EMPA) …

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Risk prediction models for delirium in ICU patients: a systematic review and critical appraisal

Wen‐Hua Chen, Lei Ding, Yue Sha, Guoping Lü et autres

OBJECTIVE: This systematic review aimed to critically appraise the methodological quality, predictive performance, and clinical applicability of published risk prediction models for delirium in adult intensive care unit patients. METHODS: We searched PubMed, Embase, Web of Science, and the Cochrane Library from …

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Risk prediction models for delirium in ICU patients: A systematic review and critical appraisal

Wen‐Hua Chen, Lei Ding, Yue Sha, Guoping Lü et autres

Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment

Lian Chen, Zhonghui Lu, Yunfei Hu, Lanqing Li et autres

Abstract Cancer therapy faces significant challenges due to drug resistance and the limitations of conventional treatments that primarily target single mechanisms such as apoptosis. Herein, we designed and synthesized a class of 1,2,4-triazolopyrimidinyl derivatives as multifunctional chemotherapeutic agents that trigger both ferroptosis …

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Environmentally sensitive fluorescent probes for the visualization of selective proteins: Recent progress and biomedical applications

Jinhui Hu, Lulu Jiang, Lanqing Li, Wen‐Hua Chen

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