Tao Jiang

Unlocking intrinsically chiral bipyrenyl-based aggregation-induced emission luminogens: circularly polarized luminescence and dynamic chirality amplification

Zhixin Xie, Junpeng Deng, Dan Liu, Jieyu Lin et autres

in the solid state. Morphological and CP-fs-TA studies reveal that the amplified chiroptical properties stem from helical self-assembly and prolonged excited-state chiral conformational reorganization in aggregates. This work establishes a design strategy for high-performance CPL materials by integrating intrinsic chirality, AIE properties, …

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Intratumoral microbiota in colorectal cancer: roles, therapeutic potential, and challenges

Junwen Qi, Chenhua Dong, Long Zhang, Junnan Chen et autres

BACKGROUND: Colorectal cancer (CRC) is a multifactorial disease characterized by disruptions in cellular and immune functions, influenced by genetic mutations, environmental factors, and infections. Recent studies have highlighted the intratumoral microbiota as a critical component of the tumor microenvironment (TME), with a …

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Graded prognostic assessment model for bone-only metastasis in extensive-stage small cell lung cancer

Fei Zhou, Donghai Liang, Xu Chen, Tao Jiang et autres

BACKGROUND AND AIM: Extensive-stage small cell lung cancer (ES-SCLC) is characterized by rapid progression and a high incidence of metastasis, particularly to the bones. Patients with bone-only metastasis (BOM) face unique challenges in prognosis and treatment. This study aimed to develop a …

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A role for INPP5D in aerobic exercise-mediated attenuation of microglial activation and neuroinflammation in Alzheimer's disease

Tao Jiang, Yueyang Zhuang, Junzi Wang, Zhimin Ding et autres

PURPOSE: Neuroinflammation is closely linked to the pathogenesis of Alzheimer's disease (AD) and the associated deficits in learning and memory. Microglial activation serves as a central mediator of this inflammatory response. While previous studies have shown that aerobic exercise exerts protective effects …

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Small cell lung cancer: relationship with HLA-I alleles and gene mutation

Xuanpeng Wu, Fei Xue, Tao Jiang, Hao Wang et autres

BACKGROUND: Small cell lung cancer is the most malignant subtype of lung cancer and has a poor prognosis. However, the mechanism is not well understood. The aim of this study was to investigate the characteristics of gene mutation in small cell lung …

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Dual-tracer PET/CT with [68Ga]Ga-PSMA−617 and [68Ga]Ga-RM26 improves early prediction of biochemical failure in prostate cancer: a prospective phase II trial

Jinhui Yang, Yongxiang Tang, Ling Xiao, Axel Rominger et autres

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[Construction of a Prognostic Risk Prediction Model for Multiple Myeloma Patients after Bortezomib Treatment Based on Decision Tree Algorithm].

Tao Jiang, Yuan Luo, Huan Wang, Hui Li

OBJECTIVE: To explore the influencing factors on the prognosis of patients with multiple myeloma (MM) after bortezomib treatment, and construct a decision tree risk prediction model based on the influencing factors. METHODS: One hundred and seventy MM patients admitted to the People's …

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Clinical Patterns of Dyslipidemia in Patients With Initial-Treatment and Drug-Naïve Schizophrenia

Lin Zhang, Tao Jiang, Guangya Zhang

Background: Schizophrenia (SCZ) is a common, chronic, severe mental disorder that is often accompanied by dyslipidemia and linked to decreased life expectancy. The prevalence of dyslipidemia among initial-treatment and drug-naïve (ITDN) patients with SCZ and the correlates influencing its occurrence and severity …

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Effect of aerobic exercise combined with meditation on cognitive frailty: study protocol for a parallel group randomised controlled trial

Feng Chen, Wenju Wang, Tao Jiang, Jingfang Zhu et autres

INTRODUCTION: Cognitive frailty (CF) is a clinical syndrome characterised by the concurrent occurrence of physical frailty and cognitive impairment, excluding Alzheimer's disease and other forms of dementia. Recent studies have shown that combining aerobic exercise (AE) and meditation (ME) effectively enhances both …

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A Body Shape Index (ABSI) as a risk factor for all-cause mortality among US adults with type 2 diabetes: evidence from the NHANES 1999–2018

Feng Chen, Xi Xie, Weilin Liu, Jingfang Zhu et autres

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Non-invasive Brain Stimulation Combined with Exercise on Gait in Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis

Feng Chen, Wenju Wang, Rui Li, Xi Xie et autres

BackgroundEffects of Non-invasive brain stimulation (NIBS) combined with exercise on gait in patients with Parkinson's disease (PD) have been highly inconsistent.ObjectiveTo assess the clinical effects of NIBS combined with exercise on gait in PD and analyze the specifics of the intervention protocols …

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Atezolizumab in High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Robert I. Haddad, Jérôme Fayette, Maria Teixeira, Kumar Prabhash et autres

Importance: Treating locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) involves any combination of surgery, radiation, and chemotherapy, followed by routine monitoring for local recurrence or distant metastases. Given the poor patient outcomes, a significant unmet clinical need …

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