Tae Hyun Park

Abstract 4369645: Retinal Vascular and Renal Biomarkers Predict Systemic Cardiovascular and Kidney Disease in the Brazilian Multilabel Ophthalmological Dataset (BRSET)

Sahil Thakur, Sparsh Rastogi, Khushboo Modi, A.V. Rukmini et autres

Background: Cardiovascular disease (CVD) and chronic kidney disease (CKD) are leading global causes of morbidity and mortality, often exacerbated by late diagnosis and limited access to early detection methods. Conventional diagnostic tools are frequently invasive or inaccessible in resource-limited settings. Retinal imaging …

in (code pays fourni par la source)

EXPLORING THE UTILITY OF A CVD RISK PREDICTING RETINAL AI MODEL IN IDENTIFYING CACS OVER 400 IN PATIENTS WITH AND WITHOUT DIABETES

Dongjin Nam, Sahil Thakur, A.V. Rukmini, Jungkyung Cho et autres

ASCVD/CVD Risk Assessment Dr. Noon CVD, a CVD risk prediction model based on retinal-imaging has been shown to estimate probability of coronary artery calcium (CAC). Dr.Noon risk categories (low, moderate, high) have shown performance comparable to conventional CAC risk categories (0, 1-99, …

kr, sg, Éthiopie, us (code pays fourni par la source)

Comparative microbiome analysis of contracted breast capsules: a cross-sectional study

Tae Hyun Park, Min‐Ji Kim, Y S Lee, Joon Seok Lee et autres

BACKGROUND: Despite the implication of bacterial biofilms in the etiology of capsular contracture, there is limited research on the microbial structure of the contracted capsule. Moreover, the potential role of the skin microbiome in capsular contracture remains undefined. Therefore, we conducted this …

kr (code pays fourni par la source)

BPS2025 - The mechanism of PIP2 inhibition of rod cyclic nucleotide-gated channel

Tae Hyun Park, Crina M. Nimigean

BPS2025 - The mechanism of PIP2 inhibition of rod cyclic nucleotide-gated channel

Tae Hyun Park, Crina M. Nimigean

Structural basis for bacteriophage P22 assembly and infection initiation

Chunyan Wang, Huaxin Yu, Tae Hyun Park, Ian J. Molineux et autres

us, jp (code pays fourni par la source)

Stronger binding affinities of gp120/CD4 in Catarrhini provide insights into HIV/host interactions

Vladimir Li, Chul Lee, Tae Hyun Park, Erich D. Jarvis et autres

Human immunodeficiency virus-1 (HIV-1) exploits the viral gp120 protein and host CD4 / CCR5 receptors for the pandemic infection to humans. The host co-receptors of not only humans but also several primates and HIV-model mice can interact with the HIV receptor. However, …

kr, us (code pays fourni par la source)

Indications for Furlow Double-Opposing Z-Plasty in Patients with Velopharyngeal Insufficiency following 2-Flap Palatoplasty

Tae Hyun Park, Hyun Su Kang, Jeong Yeop Ryu, Joon Seok Lee et autres

BACKGROUND: Various surgical methods have been developed for treating velopharyngeal insufficiency (VPI); however, the choice of surgical treatment is controversial. The pharyngeal flap, which is commonly used, has a high success rate but frequently leads to airway complications. Furlow double-opposing Z-plasty (DOZ) …

kr (code pays fourni par la source)

Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study

Jung‐Hoon Kim, Navin Pandit, Miyoun Yoo, Tae Hyun Park et autres

Abstract BRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising therapeutic targets for treating various diseases, including cancers. BRD4 is a well-studied target, and many chemical scaffolds for inhibitors have been …

kr, us (code pays fourni par la source)

BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity

Seung-Hyun Bae, Jung‐Hoon Kim, Tae Hyun Park, Kyeong Lee et autres

Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating macrophage efferocytosis. Studies are underway to develop small-molecule chemicals that inhibit MERTK as cancer immunotherapeutic agents, but these efforts are in their early stages. …

kr, us (code pays fourni par la source)

Discovery of BET specific bromodomain inhibitors with a novel scaffold

Navin Pandit, Miyoun Yoo, Tae Hyun Park, Ji‐In Kim et autres

kr, us (code pays fourni par la source)

The structure of Deinococcus radiodurans transcriptional regulator HucR retold with the urate bound

SooHo Rho, WeonSeok Jung, Jeong Kuk Park, Min Hee Choi et autres

kr, us (code pays fourni par la source)