Can Chen

An eight-variable risk model for short- and long-term mortality in hospitalized heart failure

Tao Chen, Ming Li, Qiong You, Shihan Yuan et autres

Abstract Heart failure (HF) is a leading cause of hospitalization and death worldwide, yet most prognostic models target long-term outcomes and are not optimized for acute-phase risk stratification. This study developed and externally validated an 8-variable Cox model for predicting 28-day and …

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Platelet trajectory patterns and 28-day mortality in ICU stroke patients: a retrospective cohort study based on the MIMIC-IV database

Tao Chen, Rui Liang, Riping Xu, Can Chen

Abstract Background Stroke remains a leading cause of death and disability worldwide. Platelet abnormalities are common in critically ill patients, but dynamic trajectory patterns and their prognostic value in intensive care unit (ICU) stroke patients remain unclear. Methods This retrospective cohort study …

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circ_0004090 Modulates atrial fibrosis through mir-590-5p-mediated regulation of the TGF-β/smad pathway

Weiyan Li, Hemanyun Bai, Fengya Zeng, Haitao Huang et autres

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A 2.38–3.07 GHz low power low phase noise DCO with 3-bit switched-capacitor array and 8-bit DAC

Weiye Chen, Can Chen, Jingyun Yao, Wei Zou et autres

This paper presents a low power, low phase noise ring digitally controlled oscillator (DCO) for 2.4 GHz Internet-of-Things (IoT) all-digital phase-locked loops (ADPLLs). The core comprises two stages of differential delay cells and a digital-to-analog converter (DAC). The delay cell employs a …

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The role of m6A in vascular-related diseases: Regulatory mechanisms and therapeutic implications

Can Chen, Wenjing Liu, Xiongbin Chen, Jie Ma

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Feasibility of vinegar processing of toxic herbs in Shi–Zao–Tang: toxicity reduction, efficacy preservation in malignant ascites rats and underlying pharmacodynamic mechanisms

Jin‐Di Xu, Xiaoqin Gao, Rongling Zhong, Jing Zhou et autres

BACKGROUND: Shi-Zao-Tang (SZT), a classical formula of Traditional Chinese Medicine orally used for treating malignant ascites effusion (MAE), is made by mixing the powder of Kansui Radix (KR), Euphorbiae Pekinensis Radix (EPR) and fried Genkwa Flos with the decoction of Jujubae Fructus. …

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A collagen/silk fibroin/magnesium hydroxide multifunctional sponge with enhanced mechanical strength, rapid hemostasis, and antibacterial properties for promoting infectious wound healing

Jianwei Mao, Shaotang Xiong, Xuan Wu, Zhiwei Sun et autres

Hemostatic intervention at the bleeding site during early-phase wound management plays a crucial role in reducing trauma-induced complications and mortality, while advanced wound dressings facilitate hemorrhage control, exudate management, and antimicrobial protection to promote optimal healing outcomes. To address these issues, we …

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Biodegradable poly(CL-co-TOSUO)/curcumin membrane: Biocompatibility and IL-6 suppression in atherosclerosis-relevant macrophage inflammation

Dongping Chen, Qingfa Liu, Yang Lu, Can Chen et autres

Atherosclerotic plaque instability, driven by macrophage-derived foam cells and exacerbated by interleukin-6 (IL-6), necessitates localized anti-inflammatory strategies. To address this, we developed curcumin-loaded poly(ε-caprolactone-co-4-ethylenediol ketal-ε-caprolactone) (PCT) membranes via electrospinning, characterizing their sustained drug release, biodegradability, and morphology through SEM. Comprehensive in vitro …

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Prognostic significance of angiogenesis-associated molecules and Immunologic characteristic in elderly patients with acute myeloid leukemia

Can Chen, Yongfen Huang, Lingling Wang, Linlin Zhang et autres

BACKGROUND: Neovascularization mechanisms are hyperactivated in tumors, leading to vascular dysfunction and contributing to tumor metastasis and growth. This study aims to comprehensively analyze angiogenesis-associated genes in relation to the prognosis of elderly patients with acute myeloid leukemia (AML). METHODS: Leukemia gene …

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tRF5–22-SerGCT-1 protects the heart against myocardial injury by targeting MSK1

Fanji Meng, Hemanyun Bai, Kangling Ke, Lingyan Fang et autres

AIM: This study aims to explore the expression profiles and potential functions of tsRNAs in MI. METHODS: Using a mouse model of MI induced by coronary artery ligation, we used smallRNA array to obtain tsRNAs expression profiles. Reverse transcription quantitative polymerase chain …

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Synergistic antitumor activity of azacitidine and ubenimex on acute myeloid leukemia cells

Can Chen, Yongfen Huang, Linlin Zhang, Mei Zhou et autres

Acute myeloid leukemia (AML) is a malignancy with high mortality rate and a poor prognosis. Despite advances in targeted agents, effective treatment of AML remains a major clinical challenge. Azacitidine (5AZA) induces apoptosis and has been shown to be therapeutically effective in …

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Multifunctional Organic Aniline Molecule with Interface and Bulk Defect Modification for Efficient Inverted Perovskite Solar Cells

Zhuo Lv, Zhu Ma, Qian Zhang, Bo Chen et autres

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