Li Qun Zhou

Autonomic dysfunction in laryngopharyngeal reflux: heart rate variability and its association with esophageal motility

Li Qun Zhou, Jing-tian Huang, Xiaowei Zheng, Ting Chen et autres

cn (code pays fourni par la source)

Development and validation of a plasma miRNA-CEA biomarker panel for early detection of lung cancer

Joji Samejima, Li Qun Zhou, Tōru Kimura, Yu Jin et autres

Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, underscoring the critical need for early detection to improve patient outcomes. This study aimed to develop and validate a plasma microRNA (miRNA) biomarker panel for the early detection of non-small cell …

jp, us (code pays fourni par la source)

Immunological landscape of radiation‐induced cardiac injury

Dan Ou, Han Xue Zhao, Ran Wu, Keman Liao et autres

Abstract Radiation‐induced heart disease (RIHD) is a serious complication of radiotherapy and a major contributor to non‐cancer mortality. This study employs single‐cell RNA sequencing technology to investigate the dynamic immune landscape following radiation‐induced cardiac injury, uncovering potential mechanisms of RIHD and providing …

cn (code pays fourni par la source)

Hyperuricemia-induced kidney injury: a narrative review of mechanisms and therapeutic advances

Yang Zhang, Fudong He, Xuezhi Yu, Tiantian Li et autres

Uric acid (UA) is the final product of purine metabolism in the human body. Excessive accumulation of UA leads to hyperuricemia (HUA) and the deposition of UA crystals in tissues, including the joints and kidneys. HUA has been identified as an independent …

cn (code pays fourni par la source)

Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-Phase chronic myeloid leukemia (CML-CP) in a registrational randomized Phase 2 trial: Up to 4-year follow-up including patients without T315I mutations

Qian Jiang, Zongru Li, Yanli Zhang, Yu Hu et autres

Abstract Introduction This was a multicenter, randomized, registrational phase 2 study to assess efficacy and safety of olverembatinib vs. BAT in pts with CML-CP resistant and/or intolerant to three TKIs (imatinib [I]), dasatinib [D], nilotinib [N]) in China. This report updates an …

cn, hk (code pays fourni par la source)

Olverembatinib in accelerated-phase chronic myeloid leukemia: efficacy and safety evaluation

Mengyao Yuan, Li Qun Zhou, Weiming Li, Xin Du et autres

We studied 130 consecutive subjects who presented with (N=29) or transformed to (N=101) accelerated-phase chronic myeloid leukemia (CML) and who received olverembatinib. Sixty-two were in second chronic phase. All failed ≥1 tyrosine kinase inhibitor (TKI) and 91 had BCR::ABL1T315I. Median follow-up was …

cn, gb (code pays fourni par la source)

[Corrigendum] UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells

Yan Gong, Peng Ding, Xiang Ning, Xin Yu Yang et autres

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, for the cell proliferation assay experiments shown in Fig. 3A, the Control data panels shown for days 1-5 were apparently matching with the …

cn (code pays fourni par la source)

Disease burden of interstitial lung disease and pulmonary sarcoidosis from 1992 to 2021 and prediction of future disease burden trend in China

Xie ZhiQin, Yunyu Du, Li Qun Zhou, Min Zhang et autres

Background: The prevalence of interstitial lung disease (ILD) and pulmonary sarcoidosis (PS) is rising, posing a significant health concern globally and particularly in China. This study aims to elucidate the disease burden of ILD & PS in China and to provide projections …

cn (code pays fourni par la source)

Deep learning model for predicting lymph node metastasis around rectal cancer based on rectal tumor core area and mesangial imaging features

Lili Guo, Kuang Fu, Wenjia Wang, Li Qun Zhou et autres

Assessing lymph node metastasis (LNM) involvement in patients with rectal cancer (RC) is fundamental in disease management. In this study, we used artificial intelligence (AI) technology to develop a segmentation model that automatically segments the tumor core area and mesangial tissue from …

cn, es (code pays fourni par la source)

Methodological considerations for assessing laparoscopic tumor load as an independent prognostic marker in advanced ovarian cancer

Li Qun Zhou, YJ Song

cn (code pays fourni par la source)

Signatures of tumor microenvironment-related genes and long noncoding RNAs predict poor prognosis in osteosarcoma

Ying Lu, Li Qun Zhou

INTRODUCTION: Osteosarcoma is an aggressive bone cancer with poor outcomes, especially in young individuals. This study sought to identify tumor microenvironment-related genes (TMIEGs) and associated long noncoding RNAs (TMIELs) that influence patient prognosis. MATERIALS AND METHODS: Data from the TARGET osteosarcoma and …

cn (code pays fourni par la source)

Can mutation abundance assess the biological behavior of BRAFV600E-positive papillary thyroid carcinoma?

Yeqin Ni, Ping Song, Xiangfeng Lin, Jingjing Shi et autres

BRAFV600E mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAFV600E mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated whether BRAFV600E mutation status and abundance are related …

cn (code pays fourni par la source)