Xiaolu Liu

Ameliorative Effect of Luteolin on H2O2-Induced Mitophagy and Apoptosis in Cardiomyocytes Through Modulation of the AMPK/mTOR Pathway

Zhipeng Yang, Xiaolu Liu, Daijian Liu, Kuiying Ma et autres

Background: Luteolin, a natural flavonoid, is an active ingredient in traditional herbs used to treat cardiovascular diseases. However, little is known about the effects of luteolin on oxidative damage in cardiomyocytes, and the underlying mechanisms remain poorly understood. Therefore, this study aimed …

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Origin Identification of Scutellariae radix Based on Multidimensional Quality Indicators and Machine Learning Algorithms

Xiaolu Liu, Tong Zhu, Mingyue Zhang, Jun-Xuan Yang et autres

This study aims to establish an origin identification method for Scutellariae radix that integrates multidimensional quality indicators and machine learning algorithms, enabling accurate and rapid traceability of Scutellariae radix medicinal materials from four production areas: Hebei (HB), Shanxi (SX), Shaanxi (SAX), and …

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Risk factors and prediction model for carbapenem-resistant organism infection in sepsis patients

Ronghua Liu, Xiang Li, Jie Yang, Yue Peng et autres

BACKGROUND: It aimed to identify the key risk factors associated with carbapenem-resistant organism (CRO) infections in septic patients, and subsequently develop a nomogram and assess its predictive accuracy. METHODS: The study population comprised adult critically ill patients with sepsis, drawn from the …

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Apolipoprotein E genotype is associated with island sign in lobar intracerebral hemorrhage

Qiong Yang, Haixin Sun, Xinran Ma, Lu Tang et autres

Background The island sign is a predictor of hematoma expansion and worse outcomes in patients of spontaneous primary intracerebral hemorrhage (ICH). The biological mechanism of the island sign remains unclear, but its presence might be influenced by the underlying vasculopathy related to …

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Subarachnoid hemorrhage and finger-like projection predict recurrence in patients with lobar intracerebral hemorrhage

Xin Huang, Xiangzhu Zeng, Lu Tang, Xiaolu Liu et autres

BACKGROUND AND PURPOSE: Lobar intracerebral hemorrhage (ICH) is associated with a high risk of recurrence, particularly in elderly patients, where cerebral amyloid angiopathy (CAA) is often the primary cause. Diagnostic markers of CAA-related ICH, including subarachnoid hemorrhage (SAH) and finger-like projection (FLP), …

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Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage

Qiong Yang, Xiangzhu Zeng, Lu Tang, Xiaolu Liu et autres

Background and objective We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP). Methods We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. …

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Terminally differentiated cytotoxic CD4 + T cells were clonally expanded in the brain lesion of radiation‐induced brain injury

Xueying Ma, You Zuo, Xia Hu, Sitai Chen et autres

Abstract Background Accumulating evidence supports the involvement of adaptive immunity in the development of radiation‐induced brain injury (RIBI). Our previous work has emphasized the cytotoxic function of CD8+ T cells in RIBI. In this study, we aimed to investigate the presence and …

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Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation

Tong Yang, Xiaolu Liu, Yue Zhou, Lipeng Du et autres

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Sanpian Decoction Ameliorates Cerebral Ischemia-Reperfusion Injury Via the SIRT1/ERK/HIF-1α Pathway by in Silico Analysis and Experimental Validation

Tong Yang, Xiaolu Liu, Yue Zhou, Lipeng Du et autres

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TAK1 Improves Cognitive Function via Suppressing RIPK1-Driven Neuronal Apoptosis and Necroptosis in Rats with Chronic Hypertension

Jing Yang, Pei Sun, Xiangming Xu, Xiaolu Liu et autres

Chronic hypertension is a major risk factor for cognitive impairment, which can promote neuroinflammation and neuronal loss in the central nervous system. Transforming growth factor β-activated kinase 1 (TAK1) is a key molecular component in determining cell fate and can be activated …

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Sanpian Decoction Ameliorates Cerebral Ischemia-Reperfusion Injury by Regulating SIRT1/ERK/HIF-1α Pathway Through in Silico Analysis and Experimental Validation

Tong Yang, Xiaolu Liu, Yue Zhou, Lipeng Du et autres

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CT-Visible Convexity Subarachnoid Hemorrhage Predicts Early Recurrence of Lobar Hemorrhage

Qiong Yang, Xiangzhu Zeng, Zhou Yu, Xiaolu Liu et autres

Background and Purpose Convexity subarachnoid hemorrhage (cSAH) may predict an increased recurrence risk in cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) survivors. We aimed to investigate whether cSAH detected on CT was related to early recurrence in patients with ICH related to …

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