Min Fang

GLP-1 agonist, semaglutide use in acute pulmonary embolism recovery: a four-week proof-of-concept study including proteomic profiling

Chinthaka Bhagya Samaranayake, Y Chen, Min Fang, Christopher J. Rhodes et autres

Abstract Aims Vasorelaxant and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) agonists support their investigation in aiding the recovery of patients with acute pulmonary embolism (PE) at risk of worse outcomes. Methods We undertook a four week non-randomized, controlled open-label study examining proteomic …

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White matter retention on 18F-florbetapir positron emission tomography independently predicts cognitive decline and response to anti-amyloid therapy in Alzheimer’s disease

Jin‐Tai Yu, Ying Zhang, Ruiqing Ni, Min Wang et autres

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Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging

Min Fang, Huanghuang Huang, Jie Yang, Shuying Zhang et autres

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No sex difference was found in the safety and efficacy of intravenous alteplase before endovascular therapy

Min Fang, Chenhaoyi Xu, Lan Ma, Yue Sun et autres

Background and purpose Prior studies on sex disparities were post-hoc analyses, had limited treatment modalities, and had controversial findings. Our study aimed to examine whether sex difference modifies the effect of intravenous alteplase before endovascular therapy. Methods We conducted a multicenter prospective …

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Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification

Chenhaoyi Xu, Huanghuang Huang, Min Zhang, Pei Zhang et autres

Activity-regulated cytoskeleton-associated protein (ARC) is activated by the induction of long-term potentiation and plays an important role in the synaptic plasticity of memory consolidation. Previous studies have shown that abnormal expression of ARC in the brains of patients with Alzheimer’s Disease (AD) …

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Development and validation of a clinical model (DREAM-LDL) for post-stroke cognitive impairment at 6 months

Yi Dong, Mengyuan Ding, Mei Cui, Min Fang et autres

INTRODUCTION: This multicenter, retrospective study assessed the prevalence of post-stroke cognitive impairment (PSCI) 6 months after acute ischemic stroke (AIS) and its risk factors to build a bedside early predictive model for PSCI using the Montreal Cognitive Assessment (MoCA). METHODS: Records of …

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Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity

Chenhaoyi Xu, Min Zhang, Lu Zu, Pei Zhang et autres

OBJECTIVE: This study aimed to investigate the regulatory effects of repressor element-1 silencing transcription factor (REST) on the glutamate receptors and immediate early genes (IEGs) in the SH-SY5Y cells. METHODS: The genes regulated by REST were screened by bioinformatics between AD patients …

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Multidimensional intervention in individuals with mild cognitive impairment: a pilot nonrandomized study

Shaofang Xu, Guilin Meng, Pengfei Chen, Min Fang et autres

BACKGROUND: There is an increasing need for non-pharmacological treatments that can enhance the cognitive function of individuals with mild cognitive impairment. We firstly performed multidimensional intervention based on the concept of the International Classification of Functioning, Disability and Health, and aimed to …

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Pilot testing the caregiver self-management intervention for caregivers of relatives with dementia

Shu Ying Zhang, Fan Wu, Dan Li Tang, Xiao Rong et autres

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High Aβ load may cause microglial cell dysfunction and reduced nuclear repressor element-1 silencing transcription factor (REST) expression which might be ascribed to its degradation by ubiquitination

Min Fang, Yanxin Zhao, Xueyuan Liu

BACKGROUND: This study aimed to investigate the effects of high Aβ load on the microglial function, neuronal activity, and repressor element-1 silencing transcription factor (REST) expression and nuclear localization and further explore the mechanism underlying nuclear REST deficiency and the correlation between …

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Abstract WP563: Risk Factors Related to the Development of Post Stroke Cognitive Impairment in Shanghai Stroke Population

Yi Dong, Mei Cui, Min Fang, Li Gong et autres

Background: Post-stroke cognitive impairment (PSCI) or post-stroke dementia (PSD) may affect one third of stroke patients. Understanding the risk factors related to the development of PSCI or PSD in acute stroke may help prevent and treat PSCI or PSD. A large-scale examination …

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Safety and Efficiency of Low Dose Intra-arterial Tirofiban in Mechanical Thrombectomy During Acute Ischemic Stroke

Tongya Yu, Yingying Lin, Aiping Jin, Pei Zhang et autres

OBJECTIVE: In this study, we aimed to evaluate the safety and efficiency of low dose intra- arterial tirofiban in mechanical thrombectomy of acute ischemic stroke patients to facilitate the reperfusion of distal vessel. METHODS: We retrospectively analyzed 54 consecutive acute ischemic patients …

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