Zeyuan Wang

Dysbiosis of oral bacteriome and mycobiome associated with the severity of heart failure

Hanyu Li, Qingyang Wu, Zeyuan Wang, Xiaomin Hu et autres

BACKGROUND: Heart failure (HF) is accompanied by chronic inflammation and metabolic stress, but the relationship between HF severity and the oral microbial ecosystem remains incompletely understood. This study aimed to investigate bacterial, fungal, and predicted functional alterations in supragingival plaque from patients …

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Calpain-2 inhibition alleviates hypercalcemia-driven multiple myeloma progression

Zeyuan Wang, Chaoying Yang, Yanpeng Wang, Zhiming Guo et autres

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Climate and sedimentary structure drive deep labile carbon accumulation in alpine wetlands

Youqing Yang, Jianqing Du, Hui Zhang, Zhixiang Niu et autres

Wetlands serve as vital carbon sinks; however, compared with the surface carbon pool, the relative stock and stability of organic carbon (OC) buried in deep sediment layers remain uncertain, particularly in alpine regions. Based on 42 sediment across seven wetlands on the …

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Oestrogen-related receptor γ in sepsis-induced cardiomyopathy: role of cardiomyocyte subtype conversion

Jingli Yang, Zeyuan Wang, Rui Ma, Junxia Zhang et autres

BACKGROUND AND AIMS: Sepsis remains one of the leading causes of death worldwide, and sepsis-induced cardiomyopathy (SICM) increases the overall mortality rate of sepsis patients. Currently, targeting therapies for SICM are lacking, due to the incomplete understanding of the pathophysiological mechanisms of …

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CCL17 as an Inflammatory Biomarker Enhances Cardiovascular Risk Stratification: a Prospective Cohort Study

Zeyuan Wang, Xiaoyu Ren, Lu Yang, H. J. Yang et autres

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Renal Artery Function and Histopathology Linked to Plasma and Fecal Metabolites in Heart Failure Patients

Junxia Zhang, Jingli Yang, Xuya Kang, Zeyuan Wang et autres

The gut microbiota and its associated host-microbe co-metabolites are increasingly recognized as key regulators of systemic metabolic balance and the cardiorenal axis, particularly within the context of cardiorenal syndrome. Although clinical evidence indicates that cardiac dysfunction may initiate or exacerbate renal pathological …

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Abstract Thu128: Chemokine CCL17：bridging innate and adaptive immunity to drive thoracic aortic aneurysm progresssion

Zeyuan Wang, Yang Zhang, Zhuang Tian, Shuyang Zhang

Background: Thoracic aortic aneurysm (TAA) is a life-threatening disease with limited preventive and therapeutic options. While dysregulation of the immune microenvironment has been implicated in TAA pathogenesis, the key mediators driving vascular remodeling remain unidentified. Methods: We prospectively enrolled TAA patients (n=32) …

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Advancing biomolecular understanding and design following human instructions

Xiang Zhuang, Keyan Ding, Yinuo Jiang, Xiaotong Li et autres

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Genetic landscape of hereditary cardiomyopathies and arrhythmias in China

Lu Yang, Zeyuan Wang, Shuyuan Zhang, Yaping Liu et autres

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Apalutamide-associated rash combined with severe neutropenia and eosinophilia: a case report

Yuan Shao, Zihao Liu, Yinchi Zhang, Zhen Yang et autres

Background: Apalutamide is approved for the treatment of nonmetastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). Currently, the incidence of rash is higher in patients treated with apalutamide. However, the occurrence of apalutamide-associated skin rash combined with apalutamide-induced neutropenia …

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A Genetic Perspective to Reveal the Impact of Mitochondrial Dysfunction-related Genes on Diabetic Kidney Disease: A Multi-omics Study

Yan Zhang, Zeyuan Wang, Jin Shang, Yijun Dong et autres

OBJECTIVE: This study investigated the causes of Mitochondrial Dysfunction (MD) in Diabetic Kidney Disease (DKD) progression, and identified genes associated with DKD, especially those with significant genetic causal effects, to provide a theoretical basis for DKD treatment. METHODS: Using a large database …

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Unraveling gut microbiome alterations and metabolic signatures in hereditary transthyretin amyloidosis

Hanyu Li, Zeyuan Wang, Shan He, Xinyue Zhao et autres

ABSTRACT Hereditary transthyretin amyloidosis (hATTR) is a rare, often fatal disease characterized by the abnormal aggregation of atypical transthyretin fibrils. Given the variability in the penetrance and clinical manifestations of hATTR, the role of nongenetic factors, particularly those related to the gut …

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