Hu Zhang

Echinacoside Alleviates Non‐Alcoholic Fatty Liver Disease in Rats: Potential Involvement of AMPK Pathway and Autophagy

Shengnan Li, Qingyan Jiang, Ting Shi, Dong-Ao Fan et autres

The primary objective aims to evaluate the therapeutic efficacy of echinacoside in ameliorating hepatic steatosis and exploring its role in modulating autophagic flux through AMP-activated protein kinase (AMPK) signaling, positioning it as a potential treatment for non-alcoholic fatty liver disease (NAFLD). A …

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[Protective effect of recombinant Schistosoma japonicum cystatin against acute kidney injury associated with acute liver failure in mice].

Yu Xue, Xiaodi Yang, Hu Zhang, Tengfei Zhang et autres

OBJECTIVE: cystatin (rSj-Cys) against acute kidney injury induced by acute liver failure and unravel the underlying mechanism, so as to provide insights into the clinical therapy of acute kidney injury. METHODS: Twenty-four male C57BL/6J mice at ages of 6 to 8 weeks …

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Mechanism of action of Zhishi Daozhi decoction in the treatment of diarrhea based on network pharmacology and molecular docking

Zhenglin Liu, Long Li, Qi-Sheng Zhong, Jun-Yu Ke et autres

Deep Eutectic Solvents in the Efficient Detoxification and Extraction of Alkaloids of Aconiti Lateralis Radix Praeparata

Zheng‐Meng Jiang, Fangfang Wang, Jie Liu, Tianqing Huang et autres

The conversion of diester-diterpenoid alkaloids (DAs) into monoester-diterpenoid alkaloids (MAs) is an effective method to reduce the toxicity of Aconiti Lateralis Radix Praeparata (Fuzi in Chinese, ALRP), a popular traditional Chinese medicine. In the present study, deep eutectic solvents (DESs) were first …

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Palladium-Catalyzed Negishi Coupling of α-CF3 Oxiranyl Zincate: Access to Chiral CF3-Substituted Benzylic Tertiary Alcohols

Hu Zhang, Stephen L. Buchwald

We report a Pd-catalyzed stereospecific α-arylation of optically pure 2,3-epoxy-1,1,1-trifluoropropane (TFPO). This method allows for the direct and reliable preparation of optically pure 2-CF 3 -2-(hetero)aryloxiranes, which are precursors to many CF 3 -substituted tertiary alcohols. The use of continuous-flow methods has …

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Drug–target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus

Jiangyong Gu, Hu Zhang, Lirong Chen, Shun Xu et autres

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In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adélie penguins

Sompon Wanwimolruk, Hu Zhang, Peter F. Coville, Dorothy J Saville et autres

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Metabolism of Quinine in Man: Identification of a Major Metabolite, and Effects of Smoking and Rifampicin Pretreatment

Sompon Wanwimolruk, Suk-Ming Wong, Hu Zhang, Peter F. Coville et autres

Our previous studies have shown that cigarette smoking and rifampicin pretreatment enhance the elimination of quinine, metabolism assumed, by analogy with quinidine, to be carried out by CYP3A (P450IIIA). This finding is unexpected since it has been shown that smoking induces the …

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