Tae Hun Kim

Single-Particle Cryo-EM of a Nucleosome Containing a Single-Strand Break at SHL −2.8 Bound to the Human PARP2 WGR Domain

Chathuni Jayathilake, Mewhinney CE, Emily L. Gregory, Rajbinder K. Virk et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Single-Particle Cryo-EM of a Nucleosome Containing a Single-Strand Break at SHL −2.8 Bound to the Human PARP2

Chathuni Jayathilake, Mewhinney CE, Emily L. Gregory, Rajbinder K. Virk et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Upcycling battery scrap into commercial-grade graphite anode materials via coal tar-assisted granulation

Jongyun Choi, Tae Hun Kim, Gyujin Song, Sei-Min Park et autres

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1H, 13C and 15N resonance assignments of the N-terminal intrinsically disordered region and WGR domain of human PARP2

Rajbinder K. Virk, Tae Hun Kim

Poly(ADP-ribose) polymerase 2 (PARP2) is a key sensor of DNA single-strand breaks that catalyzes ADP-ribosylation of itself and other substrates to initiate DNA repair. Human PARP2 contains an intrinsically disordered N-terminal domain (NTD) that mediates chromatin association and nuclear localization, a central …

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Byproduct-Compatible Upcycling of Plastic Pyrolysis Wax into Activated Carbon for Supercapacitor Electrodes

Tae Hun Kim, S Kim, Jongyun Choi, Ji Chul Jung et autres

Plastic pyrolysis is widely used to treat polyolefin-rich waste; however, wax byproducts generated during these processes are typically regarded as low-value intermediates. Here, a byproduct-compatible upcycling strategy is proposed to convert polyethylene (PE) pyrolysis wax into activated carbon, enabling integration of functional …

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High-Yield Production of Modified DNA Enables Structural Analysis of PARP2 Recognition of Nucleosomal Single-Strand Breaks

Chathuni Jayathilake, Clare E. Mewhinney, Emily R. Gregory-Lott, Rajbinder K. Virk et autres

• Optimized PCR workflow enables milligram-scale production of nucleosomal DNA. • Site-specific DNA lesions and epigenetic marks introduced enzymatically. • Engineered Nt.BsmAI-R386D nickase minimizes unwanted double-strand breaks. • Cryo-EM reveals PARP2 WGR recognition of nucleosomal SSBs. • Histone H2B tail adopts alternate …

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Enhanced Electrochemical Performance of Silicon Monoxide Negative Electrodes via Electroless Nickel Plating

Tae Hun Kim, Eun Byul Go, Haebeen Kim, Ji Heon Ryu

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Toward Circular Carbon: Upcycling Coke Oven Waste into Graphite Anodes for Lithium-Ion Batteries

Inchan Yang, Tae Hun Kim, Sei-Min Park, Jung-Chul An

This study presents a sustainable upcycling strategy to convert “Pit,” a carbon-rich coke oven by-product from steel manufacturing, into high-purity graphite for use as an anode material in lithium-ion batteries. Despite its high carbon content, raw Pit contains significant impurities and has …

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Analysis of the First and Second Laws of Engine-Driven Heat Pumps Using Low GWP Refrigerant

Hyun Joon Chung, Tae Hun Kim

The applicability of alternative refrigerants in GHP can be accurately decided by considering not only the thermodynamic efficiency of the GHP using the alternative refrigerant, but also the exergy loss.In this study, energy and exergy analyses were performed to evaluate the performance …

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Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation

Nicolas Bolik-Coulon, Philip Rößler, Michael L. Nosella, Tae Hun Kim et autres

Cellular DNA is wrapped about an octamer composed of four histone proteins forming the fundamental unit of chromatin structure, the nucleosome core particle (NCP). The intrinsically disordered tails of the histones serve as scaffolds for binding an array of proteins that regulate …

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SH003 Inhibits Proliferation and Induces Apoptosis in NSCLC Cell Lines by Inhibiting the Receptor Tyrosine Kinase-related Pathway

H.S. Hwang, Jeong-Hui Je, H.S. Lee, Tae Hun Kim et autres

Background/Aim: SH003, a novel herbal mixture consisting of Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, has shown promising anti-cancer effects in various cancers, including non-small cell lung cancer (NSCLC), which comprises approximately 85% of all lung cancer cases. Characterized by high …

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Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates

Yi‐Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal et autres

Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretical investigations of the different salt- and ATP-dependent LLPSs …

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