Xinghuai Sun

Piezo1 Promotes Scleral ECM Remodeling via Mechanical Strain–Induced Fibroblast Differentiation

Di Hu, Junhong Jiang, Xueling Zheng, Chuandong Wang et autres

Mechanical strain-induced myofibroblast differentiation is a pivotal mechanism underlying scleral extracellular matrix (ECM) remodeling in glaucoma. However, the conversion of mechanical strain into biochemical signals within scleral fibroblasts remains inadequately elucidated. This study sought to investigate the role of Piezo1 in cellular …

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In vivo neuronal visualization for ocular disease models through a novel NIR-II neurotracer

Wenhan Lu, Yicong Wang, Zihan Chen, Xinghuai Sun

Early detection of glaucomatous neurodegeneration represents a crucial approach in the fight against blindness caused by glaucoma. In clinical practice, it demands for real-time in vivo analysis of the retinal ganglion cells (RGCs) as well as their central projections under pathological conditions. …

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Clinical Analysis of Perforating Globe Injuries with Intraorbital Foreign Bodies: An 18-Year Retrospective Study

Liangliang Niu, Hui Ren, Huan Xu, Xinghuai Sun et autres

Purpose: This study investigated the clinical characteristics, management strategies, and visual outcomes of perforating ocular injuries associated with intraorbital foreign bodies (IOrFBs). Methods: We retrospectively reviewed 54 patients with perforating ocular injuries and IOrFBs admitted to the Eye & ENT Hospital of …

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Quantitative Anterior Segment SD-OCT Assessment of the Iridocorneal Angle in Chinese Patients with Open-Angle Glaucoma or Ocular Hypertension: An Observational Study

Jeff Penzner, Xinghuai Sun, Ya Xing Wang, Ni Li et autres

Purpose: We evaluated iridocorneal angle biometrics using anterior segment spectral-domain optical coherence tomography (SD-OCT) compared with Shaffer grade clinical assessments in Chinese patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) to determine which method is most suitable for preoperative angle assessment. …

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Human meibomian gland organoids to study epithelial homeostasis and dysfunction

Chuyue Yu, Xichen Wan, Jinsong Wei, Zhaoting Xu et autres

Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of the ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, which retained the cell lineages …

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Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma

Yizhen Tang, Xuanqi Zhang, Xiaoxiao Chen, Jiayong Li et autres

Glaucoma is the leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form globally and has been linked to mitochondrial dysfunction and energy deficiency. Plasma was used to investigate the energy metabolomic profiles of patients with POAG and …

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Mendelian randomization of autoimmune hepatitis and cardiovascular diseases

Feng Tang, Dong Pei, Kai Sun, Xinghuai Sun et autres

Previous studies have shown that autoimmune hepatitis (AIH) is associated with cardiovascular diseases (CVD), but the potential causal relationship between genetic susceptibility to AIH and CVD risk is unknown. This study systematically investigated the potential association between genetically determined AIH and the …

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Tumor Necrosis Factor Alpha-Mediated Interaction Between Microglia and Müller Cells Exacerbates Retinal Ganglion Cell Damage in Experimental Glaucoma

Shuying Li, Hong Zhou, Guoli Zhao, Wen‐Wen Ding et autres

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Ventilator-induced Lung Injury Associated With Endothelial Cell Mitochondrial Fission

Marissa D. Pokharel, Georgios D. Kitsios, Panfeng Fu, Alejandro Garcia Flores et autres

Abstract RATIONALE: Mechanical ventilation (MV) represents a cornerstone of supportive care for sepsis-induced acute respiratory distress syndrome. Unfortunately, cyclic positive pressure from MV can exacerbate lung injury, a phenomenon known as ventilator-induced lung injury (VILI). Recent studies highlight the crucial role of …

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Harmonizing NAD + metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

Youjia Zhang, Ming Chen, Yi Tian, Bo Qin et autres

Abstract Elevated intraocular pressure (IOP) is a critical risk factor for the development and progression of glaucoma. However, current treatments focus primarily on mechanical stress relief, neglecting the underlying issue of diminished cellular energy production in patients. In this study, we investigated …

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Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study

Lian Shu, Xiaoxiao Chen, Xinghuai Sun

OBJECTIVE: Glaucoma is a complex neurodegenerative ocular disorder accompanied by brain functional abnormalities that extend beyond the visual system. However, the causal association between the two remains unclear at present. This study aimed to investigate the potential causal relationships between glaucoma and …

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MicroRNA-106a regulates the apoptosis and oxidative stress of porcine trabecular meshwork cells by targeting FAS

Junyi Lai, Chen Tan, Yunsheng Qiao, Xinghuai Sun et autres

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