Junhui Chen

The novel endogenous micropeptide XLH-36 binds Gemin4 to promote triple-negative breast cancer metastasis

Mengwei Li, Wenwei Xie, Kexin Hu, Tiantian Li et autres

Triple-negative breast cancer (TNBC) is the most malignant breast cancer subtype. The 5-year overall survival rate of TNBC patients is 77%, but once cancer metastasis occurs, this rate drops to 12%. To date, the discovery of biomarkers associated with TNBC metastasis remains …

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Transcriptome profiling of tumor-infiltrating lymphocyte-mediated cytotoxicity against patient-derived lung cancer organoids

Hongchang Zhang, Yanling Li, Jianyi Yang, Haozhen Liu et autres

Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality, and therapies utilizing tumor-infiltrating lymphocytes (TILs) show significant promise. However, molecular signatures defining a productive TIL-mediated response remain poorly characterized. Here, we establish a patient-derived organoid and autologous TIL co-culture …

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Analysis of common treatment-related adverse events of donafenib and its correlation with efficacy: exploratory analysis of the ZGDH3 study

Feng Bi, Shukui Qin, Yuxian Bai, Zhendong Chen et autres

BACKGROUND AND AIMS: Donafenib, a deuterium-modified sorafenib derivative, has improved survival outcomes in patients with advanced hepatocellular carcinoma (HCC). This study aimed to investigate the treatment-related adverse events and their associations with overall survival (OS) and time to progression (TTP) in patients …

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KBTBD8/RRP15 as a potential novel therapeutic target associates with lenvatinib-inhibited progression in hepatocellular carcinoma both in vitro and in vivo

Saili Zhao, Xuran Wang, Rui Ting Wu, Fenglan Wang et autres

INTRODUCTION: We have previously demonstrated that RRP15 (Ribosomal RNA Processing 15 Homolog) was significantly elevated in hepatocellular carcinoma (HCC) and correlated directly with poor prognosis. RRP15 suppression curtails HCC progression through induction of cellular senescence and apoptosis. However, the impact of RRP15 …

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Similarities and differences in the response and molecular characteristics of peripheral sensory neurons associated with pain and itch

Li Liu, Jiemin Yin, Youqiang Meng, Chenghao Ye et autres

Dorsal root ganglion (DRG) neurons are responsible for the primary detection and transmission of peripheral noxious stimuli, mainly pain and itch. However, as two distinct noxious sensations, how DRG neurons respond differently to and code pain and itch is still an attractive …

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The peripheral Atf3+ neuronal population is responsible for nerve regeneration at the early stage of nerve injury revealed by single-cell RNA sequencing

Emily L. Liu, Junhui Chen, Wen Yin, Po Gao et autres

Peripheral nerve injury (PNI) can transform primary somatosensory neurons to a regenerative state. However, the details of the transcriptomic changes associated with the nerve regeneration of somatosensory neurons remain unclear. In this study, single-cell RNA sequencing (scRNA-seq) is conducted on mouse dorsal …

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Bispecific GPC3/PD‑1 CAR‑T cells for the treatment of HCC

Dezhi Li, Jie Qin, Tao You Zhou, Yaqin Li et autres

Constantly stimulated by the tumor microenvironment (TME), programmed death 1 (PD‑1) is elevated, and it interacts with PD ligand 1 (PD‑L1), rendering chimeric antigen receptor (CAR)‑T cells dysfunctional. Hence, CAR‑T cells immune to PD‑1‑induced immunosuppression were constructed to improve the function of …

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Nucleos(t)ide analogues altered quasispecies composition of hepatitis B virus (HBV)‐resistant mutations in serum HBV DNA and serum HBV RNA

Hao Liao, He Zhang, Jinman Shao, Xiaoyong Li et autres

Serum hepatitis B virus (HBV) RNA is a new serological indicator reflecting viral replication with good clinical application prospects. This study aimed to clarify the dynamic changes of serum HBV RNA levels and the quasispecies of HBV RNA virus-like particles in nucleos(t)ide …

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Lutein shows a protective effect against the aging of mesenchymal stem cells by downregulating inflammation

Keli Zhao, Tao Zhou, Jun Jie Yang, Yaqin Li et autres

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LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1β upregulation

Siliang Chen, Ping Zhang, Jia Feng, Rui Li et autres

Latent membrane protein 1 (LMP1), which is encoded by the Epstein-Barr virus (EBV), has been considered as an oncogene, although the detailed mechanism behind its function remains unclear.It has been previously reported that LMP1 promotes tumorigenesis by upregulation of peroxisome proliferator-activated receptor-γ …

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PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

Min Huang, Fang He, Dan Li, Ya‐Jia Xie et autres

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients' response to immune checkpoint blockade (ICB). Thus, restoring the cytotoxic effect of immune cells …

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Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation

Siqiaozhi Li, Jinsong He, Xin Liao, Yixuan He et autres

The importance of Fbxo22 in carcinogenesis has been highly documented. Here, we discussed downstream regulatory factors of Fbxo22 in TNBC. RNA-sequencing was conducted for identifying differentially expressed genes, followed by construction of a regulatory network. Expression patterns of Fbxo22/KDM5A in TNBC were …

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