Xin Zheng

Multi-omics analysis reveals microbiome-associated subtypes of esophageal cancer with distinct immune profiles and therapeutic responses

Hua Liu, Haixing Song, Lingling Pu, Jin Zhao et autres

BACKGROUND: Esophageal cancer is an aggressive malignancy with poor prognosis. Comprehensive molecular characterization is crucial for identifying novel therapeutic targets and improving outcomes. METHODS: We performed an integrative multi-omics analysis of esophageal tumors, profiling the microbiome, transcriptome, epigenome, and clinical data. Unsupervised …

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RETRACTED ARTICLE: Atovaquone inhibits colorectal cancer metastasis by regulating PDGFRβ/NF-κB signaling pathway

Bin Liu, Xin Zheng, Jiajun Li, Peng Guo et autres

BACKGROUND: Colorectal cancer is a common malignant tumour. Invasive growth and distant metastasis are the main characteristics of its malignant biological behaviour, and they are also the primary factors leading to death in colon cancer patients. Atovaquone is an antimalarial drug, and …

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Fenton/Fenton-like microreactor in inflammatory microenvironment: Photothermal enhanced catalytic oxidation strategy for chemodynamic treatment of rheumatoid arthritis

Xiunan Wu, Guojun Cao, Han Chen, Weiwei Sheng et autres

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Photogenerated electrons from CeO2 via upconversion of excitons to conduction band enhanced photocatalysis for Photo-Therapy of Rheumatoid arthritis

Zheng Li, Xiunan Wu, Wenxiang Gu, Peng Zhou et autres

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A multifunctional nano-therapeutic platform based on octahedral yolk-shell Au NR@CuS: Photothermal/photodynamic and targeted drug delivery tri-combined therapy for rheumatoid arthritis

Ru‐Qi Huang, Caiyi Zhang, Yeyang Bu, Zheng Li et autres

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MiR-199a-3p inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via suppressing retinoblastoma 1

Yufan Wangyang, Linhong Yi, Tao Wang, Yanbo Feng et autres

Background Fibroblast-like synoviocytes (FLSs) that line the intimal synovium play a crucial role in the pathogenesis of rheumatoid arthritis (RA). miR-199a-3p is a highly conserved miRNA that has been shown to regulate a variety of growth behaviors in diverse cell types. However, …

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Effects of pigment epithelium-derived factor on osteo-adipogenic transdifferentiation, and osteoprotegerin/receptor activator for nuclear factor-κB ligand ratio of osteoblast after stimulation of high concentrations of dexamethasone

Shaosong Sun, Xin Zheng, Xingchen Zhang, Rui Min et autres

Objective To explore the protective effect of pigment epithelium-derived factor (PEDF) on osteo-adipogenic transdifferentiation, and osteoprotegerin (OPG)/receptor activator of nuclear factor (NF)-κB ligand (RANKL) ratio of osteoblast after stimulation of high concentrations of dexamethasone (DEX). Methods MC3T3-E1 cells were randomly divided into …

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Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R

Shengcheng Yao, Yingnan Zhang, Xiaoyu Wang, Fengchao Zhao et autres

Pigment epithelial-derived factor (PEDF) is known as a widely expressed multifunctional secreted glycoprotein whose biological actions are cell-type dependent. Recent studies demonstrated that PEDF displays cytoprotective activity in several cell types. However, it remains unknown whether PEDF is involved in glucocorticoid-induced osteoblast …

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RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9

Zhikui Liu, Changwei Dou, Yuli Jia, Qing Li et autres

The retinoic acid-induced protein I (Rig-I/Ddx58), (RIG-I) initiates a signaling cascade that induces innate immune defences which is associated with the production of type I interferons (IFNs) and inflammatory cytokines to establish an antiviral state. Aberrant RIG-I signaling leads to inflammation, autoimmune …

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Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties

Sanjay Swaminathan, Xiaojun Hu, Xin Zheng, Yuliya Kriga et autres

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Correction: LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes

Mohammad Ishaq, Bor-Ruei Lin, Marjorie C. Bosche, Xin Zheng et autres

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SS4-4 Ku70 is a novel cytosolic DNA sensor and induces type-III IFN rather than Type-I IFN

Xing Zhang, Terrence W. Brann, Kristy B. Lidie, Ming Zhou et autres

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