Rui Luo

Auxin Efflux Carrier OsPIN5c Positively Regulates Cold Tolerance by Modulating Reactive Oxygen Species and Water Homeostasis in Rice (Oryza sativa L.)

Rui Luo, Guo Chen, Sheng Chen, Hanhan Wang et autres

Low temperature severely constrains plant growth, development, and geographic distribution. Although auxin is well known for its role in plant growth and development, its involvement in plant cold tolerance remains largely unclear. Here, we explored the role of OsPIN5c, an auxin efflux …

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Genomic and pathogenic characterization of a chicken-origin cluster 3.2 Tembusu virus isolated in China

Dong Chen, Hu Shuai, Yanan Zhang, Hui Jin et autres

Abstract Tembusu virus (TMUV) is an emerging flavivirus that causes encephalitis and a decrease in egg production in poultry across East and Southeast Asia. Here, we isolated and characterized a chicken-origin TMUV strain, CHN-WH, from a laying hen farm in China. Whole-genome …

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Adaptive evolution of tembusu virus enhances mammalian pathogenicity and vector competence

Tao Wang, Fan Liu, Yuyan Fan, Wei Li et autres

ABSTRACT Tembusu virus (TMUV) is an avian orthoflavivirus responsible for severe egg-drop syndrome, inflicting substantial economic losses on the poultry industry in China and Southeast Asia. TMUV exhibits zoonotic potential and has diversified into distinct phylogenetic clusters; however, the phenotypic consequences of …

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Identification of two novel B-cell epitopes targeting the hemagglutinin protein of H9N2 avian influenza virus

Dong Chen, Hongyun Wei, Y ZHANG, Dan Liu et autres

Abstract H9N2 avian influenza virus (AIV) remains a global threat to poultry health and has zoonotic potential. Antigenic drift in the hemagglutinin (HA) protein complicates vaccine efficacy and diagnostic accuracy, highlighting the need for precise epitope characterization. In this study, the HA …

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Correction for Li et al., “PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein”

Ke Li, Hongyun Wei, Kangli Zhao, Dong Chen et autres

Volume 17, no. 4, e00259-26, 2026, https://doi.org/10.1128/mbio.00259-26. Figure 4D: The anti-HA immunoblot panel corresponding to the IP samples should appear as shown in this correction. This panel was inadvertently replaced with an incorrect anti-HA immunoblot panel during figure assembly. We apologize for …

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao et autres

Epigenetic modifications furnish a hidden regulatory layer that shapes cellular fate and evolutionary potential without rewriting the genetic code. In eukaryotes, methylome maps have profoundly transformed our understanding of development, disease, and lineage diversification. In bacteria, which represent the most abundant and …

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Development and validation of a machine learning model for hospital-acquired bacterial infection prediction in acute-on-chronic liver failure

Jing-Yi Chen, Xinyi Chen, Yi-Wen Xie, Yu‐Wei Chen et autres

BACKGROUNDHospital-acquired (HA) bacterial infections are a frequent and potentially preventable driver of early deterioration in acute-on-chronic liver failure (ACLF), yet no validated tool exists to identify high-risk patients at the time of hospital admission.AIM To develop and externally validate an interpretable admission-time …

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3′,4′-Isopropylidene-α-galactosylceramide Enables Multidose Th1 Adjuvanticity Despite Limited Serial Serum IFN-γ Responsiveness

Leilei Huang, Dong Chen, Tu Xd, Yuan Lv et autres

Repeated-dose functionality is a critical but often overlooked requirement for invariant natural killer T (iNKT) cell agonists used as vaccine adjuvants. Here, we investigated whether masking the phytosphingosine 3′,4′-diol of α-galactosylceramide (αGC) could alter iNKT agonist behavior in this context. A panel …

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Coronavirus NSP5 protease cleaves CCDC50 to evade antiviral autophagy

K. Li, Hongyun Wei, Wenqiu Yin, Peng Zhou et autres

Selective macroautophagy/autophagy is a critical component of innate antiviral defense, relying on selective autophagy receptors to recognize viral cargo and deliver it for lysosomal degradation. In our recent study, we demonstrated that porcine deltacoronavirus (PDCoV) evades this pathway through its NSP5 protease. …

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PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein

Ke Li, Hongyun Wei, Kangli Zhao, Dong Chen et autres

Selective autophagy is a critical host defense mechanism that eliminates viral components through lysosomal degradation during coronavirus infection. Coronaviruses (CoVs), however, deploy countermeasures that disrupt this process, and several underlying mechanisms remain unresolved. Here, we identify the autophagy receptor CCDC50 as a …

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OsAAI1 ‐OsMADS25 Module Orchestrates Rice Root Morphogenesis Under Osmotic Stress by Coordinating the Auxin Pathway

Ning Xu, Rui Luo, Qing Long, Jianmin Man et autres

OsAAI1 belongs to the HPS_like subfamily of the AAI_LTSS superfamily, yet the molecular mechanism by which it regulates root development under osmotic stress remains unclear. In this study, we found that overexpressing OsAAI1 significantly promoted rice root system growth. Specifically, the primary …

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OsAAI1 is dependent on the nitrate pathway toregulate rice root development in response to high salt stress

Jinli Liu, Shasha Chen, Mengxia Wu, Jiaqi Zhang et autres

• OsAAI1 is salt-sensitive, inhibited by NaCl but promoted by nitrate. • Salt tolerance and ROS scavenging enzyme activity of OsAAI1 were enhanced by nitrate. • Root scanning provided more insight into root growth and development. • osaai1 was more resistant to …

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