Jianguo Zhou

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Juanyan Shen, Junliang Ma, Shaolin Chen, Qisha Li et autres

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deterioration (TTD) captures the durability of HRQoL over …

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Efficacy and Safety of Anthracyclines Combined with Temozolomide Regimens for the Treatment of Advanced Leiomyosarcoma: A Retrospective Study

Huijing Tan, Jianguo Zhou, Susheng Shi, Liming Jiang et autres

Background: Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma with high rates of hematogenous metastasis and recurrent relapse, with a 5-year survival rate of 17.0%. This study evaluated the clinical efficacy of an anthracycline plus temozolomide (ATEM) regimen in advanced LMS and …

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Maternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies

Siyi Wang, Huan Yu, Changyi Li, Lijuan Luo et autres

The association between hypertensive disorders of pregnancy (HDP) and bronchopulmonary dysplasia (BPD) in preterm infants remains controversial due to inconsistent findings in previous studies. However, systematic studies and meta-analyses evaluating the association remain limited. The study followed the Meta-analysis of Observational Studies …

Maternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies

Siyi Wang, Huan Yu, Changyi Li, Lijuan Luo et autres

The association between hypertensive disorders of pregnancy (HDP) and bronchopulmonary dysplasia (BPD) in preterm infants remains controversial due to inconsistent findings in previous studies. However, systematic studies and meta-analyses evaluating the association remain limited. The study followed the Meta-analysis of Observational Studies …

Maternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies

Siyi Wang, Huan Yu, Changyi Li, Lijuan Luo et autres

BACKGROUND: The association between hypertensive disorders of pregnancy (HDP) and bronchopulmonary dysplasia (BPD) in preterm infants remains controversial due to inconsistent findings in previous studies. However, systematic studies and meta-analyses evaluating the association remain limited. METHODS: The study followed the Meta-analysis of …

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Impact of Different Maternal Age Subgroups on Pregnancy Adverse Outcomes in China: A Multicenter Cohort Study

Yi‐Jie Zhang, Jianguo Zhou, Chao Chen

ABSTRACT Background and Aims To analyze the distribution pattern of maternal age and the impact of different maternal age subgroups on pregnancy adverse outcomes in China. Methods This is a multicenter retrospective cohort study from 2010 to 2017. Live‐born singletons were included. …

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Prolonged recurrence-free survival by autologous rectronectin-activated killer (RAK) cells in resected high-risk hepatocellular carcinoma: an experimental single-arm phase II trial (pilot study)

Yiran Wang, Jing Fan Xu, Luyao Zhang, Jinlian Tong et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is prone to recurrence following hepatectomy, posing significant clinical challenges. Our previous research suggested that adoptive T-cell therapy could improve the impaired liver microenvironment. This study aimed to evaluate the efficacy and safety of adjuvant RetroNectin-Activated Killer (RAK) …

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Three-dimensional Pseudo-continuous Arterial Spin Labeling Technique to Assess Cerebral Perfusion Changes in End-stage Renal Disease Patients Undergoing Hemodialysis

Xiangxiang Wu, Haiyang Yu, Kaixi Xu, B. Chen et autres

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Circ_0044362 Facilitates the Progression of Epithelial Ovarian Cancer via Enhancing HOXB4 Transcription to Activate the RUNX1/IGFBP3 Axis

Shuqi Ye, Han Wu, Junjiang Liu, Jianguo Zhou et autres

Increasing numbers of studies have elucidated the emerging roles of circular RNA (circRNA) in cancer progression. However, the function of circRNAs in modulating their parental genes in ovarian cancer remains poorly understood. In this study, we identified that circ_0044362, a circRNA derived …

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Chinese Expert Consensus on the Combination of Targeted Therapy and Immunotherapy with Locoregional Therapy for Intermediate/Advanced Hepatocellular Carcinoma

Xinyu Bi, Yinying Lu, Bo Chen, Zhengqiang Yang et autres

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality; it ranks as the second most common cause of cancer deaths in China. Most HCC patients are first diagnosed at an advanced stage. In recent years, targeted therapy combined with immunotherapy has …

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Consensus of Chinese Experts on Neoadjuvant and Conversion Therapies for Hepatocellular Carcinoma: 2023 Update

Xinyu Bi, Haitao Zhao, Hong Zhao, Guangming Li et autres

Hepatocellular carcinoma (HCC) is a common malignancy in China, with high recurrence rate and low resection rate among patients first diagnosed. Preoperative treatments including neoadjuvant and conversion therapy have the potential to overcome these challenges. In December 2021, Chinese expert consensus on …

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Analysis of the posterior cerebral perfusion status and clinical prognostic value in chronic unilateral middle cerebral artery occlusion using SWAN combined with 3D-ASL

Jianguo Zhou, Guifen Li, Yun Meng, Fangyun Hu et autres

To investigate the predictive value of T2 star-weighted angiography (SWAN) combined with 3-dimensional (3D) arterial spin labeling (3D-ASL) to assess cerebral perfusion status and clinical prognosis in chronic unilateral middle cerebral artery (MCA) M1 occlusion. This study included 55 patients diagnosed with …

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