Na Yang

Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models

Ma Shuai, Yingying Han, Rui Cai Gu, Qi Chen et autres

Genome instability is most commonly caused by replication stress, which also renders cancer cells extremely vulnerable once their response to replication stress is impeded. Topoisomerase II binding protein 1 (TOPBP1), an allosteric activator of ataxia telangiectasia and Rad3-related kinase (ATR), coordinates ATR …

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Studies on the Design, Synthesis, and Insecticidal Activity Evaluation of New Caffeine-Acrylate Derivatives as Potential Ryanodine Receptor Activators

Wei Wei, Haoqin Huang, Yuxin Li, Na Yang et autres

On the basis of insecticidal leading structures of methylxanthine-acrylates I and II, a series of new caffeine-acrylate derivatives A–F were designed and synthesized via various structural optimization strategies. The structures of new compounds were confirmed through 1 H NMR, 19 F NMR, …

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Zeaxanthin improves myopia by regulating the HIF-1α-glycolysis signaling pathway

Xiaoying Wen, Na Yang, Chaohui Gu, Yimeng Zhang et autres

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Synergizing Attribute-Guided Latent Space Exploration (AGLSE) with Classical Molecular Simulations to Design Potent Pep-Magnet Peptide Inhibitors to Abrogate SARS-CoV-2 Host Cell Entry

Farhan Ullah, Aobo Xiao, Shahid Ullah, Na Yang et autres

The COVID-19 infection, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has evoked a worldwide pandemic. Even though vaccines have been developed on an enormous scale, but due to regular mutations in the viral gene and the emergence of new strains …

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Research progress on histone modifications and anti-aging interventions

Rui Wang, Ting Li, Na Yang

组蛋白修饰作为表观遗传调控的核心机制，通过动态可逆的甲基化、乙酰化、泛素化和乳酸化等修饰调控染色质结构与基因表达，在衰老进程中发挥关键作用。近年研究发现，衰老伴随组蛋白甲基化失衡、乙酰化累积、泛素化失调和乳酸化下降，导致异染色质解体、转座子激活和促炎因子分泌，加速细胞衰老与组织退化。针对上述机制，抗衰老策略聚焦两大方向：小分子药物调控和基因编辑技术。当前，靶向组蛋白修饰的抗衰老小分子药物已有进入临床试验，而基于CRISPR的基因编辑疗法在动物模型中显著延长健康寿命。未来需解决组织特异性递送、长效安全性等问题，推动表观遗传干预从基础研究向临床转化，为抗衰老提供精准策略。

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Author response for "Radical-mediated proton transfer enables hydroxyl radical formation in charge-delocalized water"

Ruijuan Zhao, Qiuyue Zhang, Na Yang, Lei Li et autres

A novel multi-functional PVA- alginate hydrogel with dynamic bond crosslinking for infected wound repair

Lingling Tang, Li Huang, Na Yang, Xingyue Chen et autres

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Improved Optimized Minimum Generalized Lp/Lq Deconvolution and Application to Bearing Fault Detection

Na Yang, Zhigang Pan, Yuanbo Xu

Locating the fault-induced cyclic impulses from corrupted vibration signals is a key step in detecting bearing fault characteristics. Recently, a novel deconvolution technique named the optimized minimum generalized Lp/Lq deconvolution (OMGD) was proposed and has been validated as a useful technique to …

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Research on the Design of Upper Computer Management Software for Automotive Software Upgrade Testing

Yongjian Zhu, Ying Jing, Zhapa Mu, Na Yang

With the rapid development of automotive electronics technology, software upgrades have become a key link in ensuring vehicle performance and safety. As the core tool for software upgrade testing, the design rationality and functionality of the upper computer management software directly affect …

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A polypropylene-based all-organic dielectric polymer film with high dielectric constant, low dielectric loss, and high breakdown strength

Fuqi Zhao, Jiahao Lv, Dandan Yuan, Chong Tian et autres

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Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities

Chunyun Xu, Na Yang, Hsiao‐Wei Yu, Xiaojing Wang

Tumours and inflammation are serious risks to human health and are importantly regulated by the gas signalling molecule hydrogen sulphide. In this work, we report the rational design and synthesis of H2S donor molecules based on phenylthiophosphoryl dichloride nuclei and assess their …

A Master–Slave Game-Based Strategy for Trading and Allocation of Virtual Power Plants in the Electricity Spot Market

Na Yang, Liuzhu Zhu, Bao Wang, Rong Fu et autres

With the transformation of the energy structure, the integration of numerous small-scale, widely distributed renewable energy sources into the power grid has introduced operational safety challenges. To enhance the operational competitiveness, the virtual power plant (VPP) has emerged to aggregate and manage …

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