Honghua Wu

Exploring the evolution of China’s transportation energy consumption and carbon emissions with an intelligent nonlinear Koopman Grey Model

Yu Zhang, Lianyi Liu, Honghua Wu, Zhigeng Fang

As a major source of national carbon emissions, the transportation sector plays a critical role in China’s decarbonization strategy. This study introduces a Koopman Grey Model (KGM) to analyze and forecast the development of China’s transportation industry. By embedding the Koopman operator …

cn (code pays fourni par la source)

Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression

Ling Zhang, Wenyu Zou, Shixuan Zhang, Honghua Wu et autres

BACKGROUND: Maternal overnutrition, prevalent among women of childbearing age, significantly impacts offspring health throughout their lifetime. While DNA methylation of metabolic-related genes mediates the transmission of detrimental effects from maternal high-fat diet (HFD), its role in programming hepatic cholesterol metabolism in offspring, …

cn (code pays fourni par la source)

Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism, gut microbiota and microbial-associated metabolites

Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu et autres

Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus. However, the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully …

cn (code pays fourni par la source)

Optimal sequence of LT for symptomatic BM in EGFR-mutant NSCLC: a comparative study of first-line EGFR-TKIs with/without upfront LT

Lishui Niu, Honghua Wu, Ruihuan Gao, Liu Chen et autres

BACKGROUND: The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can penetrate blood-brain barrier and are effective for brain metastases (BMs). There is no consensus on the optimal sequence of local therapy (LT) and EGFR-TKIs for symptomatic BM patients because patients …

cn, us (code pays fourni par la source)

Maternal high-calorie diet feeding programs hepatic cholesterol metabolism and Abca1 promoter methylation in the early life of offspring

Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu et autres

Maternal high-calorie diet feeding can dramatically increase the susceptibility of metabolic diseases in offspring. However, whether maternal high-calorie diet feeding can program hepatic cholesterol metabolism in the early life of offspring is less understood, and the epigenetic mechanisms underlying this intergenerational effect, …

cn (code pays fourni par la source)

Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring

Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu et autres

Maternal overnutrition can dramatically increase the susceptibility of offspring to metabolic diseases, whereas maternal exercise may improve glucose metabolism in offspring. However, the underlying mechanism programming the intergenerational effects of maternal exercise on the benefits of glucose metabolism has not been fully …

cn (code pays fourni par la source)

P22.05 Dynamic Monitoring of Blood Samples by PEAC Technology for Early-Stage Lung Cancer Patients After Surgery

Shengnan Wang, W. Ou, Na Li, Honghua Wu et autres

cn (code pays fourni par la source)

Prenatal urinary phthalates and postpartum metabolic health in Women from Mexico City

Honghua Wu, Allan C. Just, Emily Oken, Nia McRae et autres

Studies have reported associations between phthalates, a family of ubiquitous environmental contaminants, and metabolic complications of pregnancy, but no study has considered these outcomes beyond pregnancy. We examined associations of prenatal phthalates exposure with postpartum metabolic health biomarkers in the PROGRESS cohort.The …

us, si (code pays fourni par la source)

Methylparaben in Meconium and Risk of Maternal Thyroid Dysfunction, Adverse Birth Outcomes, and Attention-Deficit Hyperactivity Disorder

Brennan H. Baker, Honghua Wu, Hannah E. Laue, Amélie Boivin et autres

Background Parabens are detected ubiquitously in human urine samples, but the effects of prenatal exposure are unclear, partially due to inadequate exposure assessment in maternal urine, which may fail to capture fetal exposure. We examined the association of meconium methylparaben detection with …

us, ca (code pays fourni par la source)

Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus

Zhirong Miao, Honghua Wu, Liu Ren, Nan Bu et autres

Aims. The objective of the present study was to explore the long-term postpartum glucose metabolism in women with previous GDM, and study the mechanism of hyperglycemia from gestation to postpartum by investigating the postpartum insulin resistance and insulin secretion. Methods. A total …

cn (code pays fourni par la source)

[Innovative insulin use in pregnancy among women with hyperglycemia].

Honghua Wu

胰岛素是孕期控制血糖的药物首选。几乎所有的孕前糖尿病、大多数妊娠期显性糖尿病、20%左右的妊娠期糖尿病需要应用胰岛素控制孕期血糖。与非孕期相比，孕期餐后血糖更高，波动更大，且随孕周进展及胎盘功能变化，血糖水平不断变化。孕期胰岛素应用需结合不同孕周血糖特点，选择合理的剂型及治疗方案，本文就包括门冬胰岛素、赖脯胰岛素、谷赖胰岛素、地特胰岛素、甘精胰岛素以及德谷胰岛素在内的胰岛素类似物在妊娠期降糖疗效和安全性作一阐述。.

cn (code pays fourni par la source)

Evaluation of the gestational diabetes mellitus diagnostic criteria recommended by the international association of diabetes and pregnancy study group for long-term maternal postpartum outcomes in mainland China

Zhirong Miao, Honghua Wu, Yang-Zi Zhang, Weijie Sun et autres

The gestational diabetes mellitus (GDM) diagnostic criteria recommended by the International Association of Diabetes and Pregnancy Study Group (IADPSG) were established based on the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study and have been the most commonly used criteria for determining GDM …

cn (code pays fourni par la source)