Yongxin Zhou

Natural selection-driven A/U-ending preference in codon usage patterns of Codonopsis chloroplast genomes

Fulin Yan, Songsong Wu, Yongxin Zhou, Shenghua Wei

Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index

Zhizhan Ni, Pengyuan Zhu, Li Liu, Haiyang Wang et autres

ABSTRACT Gastrointestinal (GI) tumours account for a significant proportion of cancer cases and deaths globally; GI tumours show similarities regarding their development, diagnosis and treatment. Genomic and transcriptome analyses have been used to describe cancers, revealing driver mutations, aberrant regulatory pathways and …

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The sealing effect and degradation of polydioxanone weaving tracheal stents in a canine airway defect model

Haihua Huang, Yi Hu, Peize Meng, Xinyue Yang et autres

The use of covered self-expandable metal (CSEM) stents for fistulas sealing is a common clinical approach. However, these stents need to be removed once their therapeutic goals are achieved. Our study designed and fabricated a dumbbell-shaped, high-porosity, biodegradable polydioxanone weaving tracheal (PW) …

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Single-cell and spatial analysis reveals macrophage-T cell crosstalk in non-small cell lung cancer immunosuppression

Pengyuan Zhu, Zhenchuan Liu, Hatim Husain, Qian Wang et autres

Background: The tumor microenvironment (TME) is instrumental in facilitating immune evasion and promoting tumor progression in non-small cell lung cancer (NSCLC). However, the spatial heterogeneity and molecular interactions between immune and non-immune cells are not yet fully understood. This research amalgamated single-cell …

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Facile fabrication of copper-carbon aerogel nanozyme for facilitating anti-tumor activity in vitro

Tingting Qin, Zhiming Wang, Guohua Zhao, Yongxin Zhou

Malignant tumors pose a significant threat to human life and health. Among these, lung cancer has become one of the most prevalent and lethal forms. The emerging in-situ catalytic Fenton reaction, which generates toxic hydroxyl radical (·OH), has shown great potential in …

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Integrated transcriptomics and metabolomics analysis of volatiles and variations in carotenoid biosynthesis during different developmental stages of Camellia huana

Zhiping Chen, Yongxin Zhou, Xia Jiang, He Li et autres

BACKGROUND: Camellia huana, an endangered plant species with a high ornamental and medicinal value, is designated as a Class I protected plant in China. In the natural state, the flowers of C. huana have golden color and fragrance; however, our study group …

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Correction: IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress

Zhenchuan Liu, Shaorui Gu, Tiancheng Lu, Kaiqing Wu et autres

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Construction of a Naphthalimide-Based Probe Towards Zn2+ and PPI and its Application in Water Sample Detection and Bioimaging

Yan Gao, Yun Liang Gao, Yongxin Zhou, Li‐Min Zhu et autres

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Study on in vivo and in vitro degradation of polydioxanone weaving tracheal stents

Haihua Huang, Yuchen Wang, Jun Zeng, Yanxue Ma et autres

Abstract The appropriate degradation characteristics of polydioxanone (PDO) are necessary for the safety and effectiveness of stents. This study aimed to investigate the degradation of PDO weaving tracheal stents (PW stents) in vitro and in vivo. The degradation solution of S. aureus …

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Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

Haoran Xia, Han Zhang, Zheng Ruan, Huibiao Zhang et autres

This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II-III non-small-cell lung cancer (NSCLC). Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg …

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Rough set Theory-Based group incremental approach to feature selection

Jie Zhao, Daiyang Wu, Yongxin Zhou, Jiaming Liang et autres

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NEK2 promotes the migration, invasion, proliferation of ESCC and mediates ESCC immunotherapy

Shaorui Gu, YakuFujiang Yasen, Mengying Wang, Baiqing Huang et autres

Purpose: Esophageal squamous cell carcinoma (ESCC) is a disease with a high incidence rate and high mortality worldwide. The Never in Mitosis A (NIMA) family member NIMA-related kinase 2 (NEK2) plays an important role in mitosis. However, the role of NEK2 in …

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