Jian Zhang

Rational design of D(+)-biotin-conjugated resorcinol dibenzyl ethers as tumor-targeted PD-L1 inhibitors for precision cancer immunotherapy

Jing-Jing Du, Rongling Liu, Lei Chen, Jian Zhang

Objectives This study aims to discover and characterize novel D(+)-biotin-conjugated PD-L1 inhibitors for precision tumor-targeted cancer immunotherapy. Methods Integrated strategies, including computer-aided molecular simulation, antiproliferative activity (CCK8) assay, surface plasmon resonance (SPR), pharmacokinetic evaluation, and in vivo antitumor efficacy assessment, were performed. …

cn (code pays fourni par la source)

A novel meshless numerical simulation approach for integrated profile control and flooding process

Yuyang Liu, Hui Zhao, Wensheng Zhou, Wentao Zhan et autres

cn (code pays fourni par la source)

Accurate prediction of RNA-binding amino acids in protein sequences with hybridRNAbind

Jian Zhang, Zhipeng Zhou, Xuan Liu, Min Li et autres

cn, us (code pays fourni par la source)

GSSA-AT: a textual adversarial defense method based on synonym substitution

Min Hua Zhu, H. Li, Hao Yan, Jian Zhang

cn (code pays fourni par la source)

High-Resolution Confocal Raman Microscopy Spectrometer Design Based on Echelle Gratings

Jian Zhang, Xiaotian Li, Jiri Jirigalantu, Xiaotao Mi et autres

To address the inherent challenge of balancing broad spectral coverage with high resolution in conventional Raman spectrometers, this paper presents a cross-dispersed confocal Raman spectrometer based on an echelle grating. First, a compound aberration correction system comprising cylindrical and spherical lenses is …

High-Resolution Confocal Raman Microscopy Spectrometer Design Based on Echelle Gratings

Jian Zhang, Xiaotian Li, Jiri Jirigalantu, Xiaotao Mi et autres

To address the inherent challenge of balancing broad spectral coverage with high resolution in conventional Raman spectrometers, this paper presents a cross-dispersed confocal Raman spectrometer based on an echelle grating. First, a compound aberration correction system comprising cylindrical and spherical lenses is …

cn (code pays fourni par la source)

Epichloë endophyte‐infected Achnatherum sibiricum and neighbouring non‐host grasses exhibit associational resistance to soil‐borne diseases

Xinyuan Ge, Na Li, Jian Zhang, Xiangqian Fan et autres

Grasses and Epichloë endophytes often form mutualistic symbiotic defence systems. Studies have shown Epichloë endophytes improve resistance of host plants to airborne diseases. However, whether endophytes affect soil-borne disease resistance of host or neighbouring non-host plants remains unclear. We used endophyte-infected (EI) …

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Application of Building Information Modeling + Algorithm Model in the “Four Preparations” for Seepage Safety of Concrete Face Rockfill Dam

Hou Yi, Bin Mei, Jian Zhang, Hong Qing Yu

Abstract Not only does China possess more than half of the total number of concrete face rockfill dams (CFRD) worldwide, but it has also experienced painful lessons regarding seepage stability control. Particularly, the continuous advancement of digital twin technology within the water …

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Automatic Building Code Review: A Case Study

Weili Xu, Michael I. Rosenberg, Jian Zhang, Aysha Siddika

Building officials, particularly those in resource-constrained or rural jurisdictions, face labor-intensive, error-prone, and costly manual reviews of design documents as projects increase in size and complexity. The growing adoption of Building Information Modeling (BIM) and Large Language Models (LLMs) presents opportunities for …

Atif-V2.0: Extending Classical Density Functional Theory with Interfacial Statistical Associating Fluid Theory for Inhomogeneous Associating Fluids

Xiujun Wang, Shichao Li, Jian Zhang, Qiuhui Chang et autres

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An Impedance-Based Method for Online Preventive Control Generation Against Wide-Band Oscillation

Wang Tu, Feng Chao Luo, Haitao Liu, Jian Zhang et autres

With the rapid increase in wind power penetration, wide-band oscillation issues caused by interactions between the fast flexible control characteristics of power electronic devices and the grid have become prominent. This paper proposes an online preventive control method against wide-band oscillation. First, …

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Efficient Neutral Nitrate-to-Ammonia Electrosynthesis Using Synergistic Ru-Based Nanoalloys on Nitrogen-Doped Carbon

Lisi Huang, Pingzhi Zhang, Xin Quan Ge, Bingyu Wang et autres

Abstract Electrocatalytic nitrate reduction reaction (NO 3 RR) represents a sustainable and environmentally benign route for ammonia (NH 3 ) synthesis. However, NO 3 RR is still limited by the competition from hydrogen evolution reaction (HER) and the high energy barrier in …

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