Yunting Zhang

Nanoparticle-mediated targeted protein degradation (NanoTPD): Principles, rational design and mechanisms of degradation

Yunting Zhang, Keran Wang, Yixiang Yang, Tao Gong et autres

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A biomimetic microneedle platform using neutrophil membrane for synergistic immune-antibacterial therapy of MRSA infection

Yihua Xu, Jiahe Wu, Yuxian Ye, Xiaolu Ma et autres

Antibiotic resistance is a major public health concern. Although novel antibiotic techniques are now in progress, immunotherapy is an unconventional and efficient approach to against resistant pathogens. Herein, an integrated microneedle patch (ANMN) was designed to mediate antibacterial immunotherapy for the management …

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Modular Nanoassemblies Mimicking p62 Aggregates for Targeted Organelle Sequestration and Degradation against Breast Cancer

Yuai Li, Yunting Zhang, Jingwen Wang, Yujie Che et autres

Selective autophagy relies on multivalent recognition by receptors like SQSTM1/p62 to form aggregates that cluster disperse organelles, undergoing liquid–liquid phase separation to facilitate their clearance and maintain cellular homeostasis. Inspired by this, we present the multivalent nanoparticle-based organelle targeting chimera (NanoTAC Org …

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Quasi‐solid Fiber‐shaped Lithium‐ion Batteries with Fire Resistance

Xiangran Cheng, Chenhao Lu, Xiaocheng Gong, Chuanfa Li et autres

Flexible batteries such as scalable fiber-shaped lithium-ion batteries (FLIBs) hold great potential for powering wearable electronics due to their excellent electrochemical performance, flexibility, and weavability. However, the use of organic liquid electrolytes raises serious safety concerns, including leakage and combustion hazards. In …

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3-Indoleacetic Acid-Modified Chondroitin Sulfate-Mediated Paclitaxel Nanocrystal Assembly for the Treatment of Pancreatic Cancer

Yueting Zhu, Ang Hu, Meilin Chen, Yunting Zhang et autres

High drug-loading nanocrystals show significant advantages in delivering hydrophobic small-molecule drugs. However, these nanocrystals face challenges, including inherent instability and limited targetability. In this study, we developed a paclitaxel nanocrystal delivery platform based on chondroitin sulfate modified with 3-indoleacetic acid (CS-IAA). Paclitaxel …

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MXene and cellulose nanocrystal co-stabilized Pickering emulsions and their applications as templates to fabricate photothermal phase change material microcapsules

Zhen Zhang, Fang Xiong, Zhenghao Wang, Wang Sun et autres

An MXene and cellulose nanocrystal co-stabilized Pickering emulsion is developed and employed as a template to fabricate photothermal phase change material microcapsules for solar energy harvesting, heat storage and release, and thermal management.

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PwnGPT: Automatic Exploit Generation Based on Large Language Models

Lin Ye, Xuetao Du, Hongli Zhang, Dongyang Zhan et autres

Current status and perspectives of clinical trials for tumor-infiltrating lymphocyte therapy

Yunting Zhang, Hongye Fu, Qiong Zhao

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Bevacizumab-induced immune thrombocytopenia in an ovarian cancer patient with mixed connective tissue disease: case report and literature review

Yunting Zhang, Fanchun Yang, Jining Wang, Hui Fu et autres

Drug-induced immune thrombocytopenia is an adverse reaction marked by accelerated destruction of blood platelets. In cancer therapy, thrombocytopenia has many other causes including bone marrow suppression induced by chemotherapeutic agents, infection, and progression of cancer; drug-induced thrombocytopenia can easily be misdiagnosed or …

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Environmental antibiotics exposure and childhood obesity: A cross-sectional case-control study

Yuqing Wang, Yu Zhang, Weifeng Tang, Zhong‐Cheng Luo et autres

Children's exposures to environmental antibiotics are a major public health concern. However, limited data are available on the effects of environmental antibiotic exposures on childhood obesity. Our study aimed to explore this relationship. We conducted a cross-sectional case-control study nested in a …

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A Mobile Applet for Assessing Medication Adherence and Managing Adverse Drug Reactions Among Patients With Cancer: Usability and Utility Study

Chenxu Ni, Yi-fu Wang, Yunting Zhang, Min Yuan et autres

BACKGROUND: Medication adherence and the management of adverse drug reactions (ADRs) are crucial to the efficacy of antitumor drugs. A WeChat applet, also known as a "Mini Program," is similar to the app but has marked advantages. The development and use of …

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Branched Perfluorohexanesulfonic Acid (Pfhxs) and Perfluoroheptanoic Acid (Pfhpa): 'Safer' Per- and Polyfluoroalkyl Substances (Pfass) Alternatives for Their Effects on Gut Microbiota and Metabolic Function in Children

Zhen Yu Hong, Li‐Zi Lin, Haoran Yu, Qinzhi Wei et autres