Jiabo Wang

Systematic Approach for Compound Angus Populations Revealing Positional Candidate Genes and Improving Prediction Accuracy in Carcass Traits

Yuanyuan Yu, Yujiao Fu, Jiahong Zhao, Shiyu Wu et autres

Carcass traits, which reflect growth performance and muscle development, are economically important in beef cattle, yet their genetic determinants remain poorly characterized. Both single-population Genome-wide association studies (GWAS) methods, such as BLINK, and cross-population meta-analysis approaches are widely used to identify genetic …

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Comparative Quantitative Profiling of Protein Lactylation Reveals a Dynamic Tissues-Specific Network Associated with Metabolic Specialization in Yaks

Zhijuan Wu, H W Yang, Junyu Chen, Jiabo Wang et autres

Protein lysine lactylation is an emerging post-translational modification with broad roles in metabolic regulation. The yak (Bos grunniens) has evolved strong metabolic adaptability on the Qinghai–Tibetan Plateau, yet its tissue-specific lactylation patterns remain poorly characterized. Here, we collected liver, muscle, and heart …

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Genome-wide detection and genomic selection based on genotype-by-environment interaction-associated signals for yak coat color

Yujiao Fu, Jiahong Zhao, Yuanyuan Yu, Binglin Yue et autres

Through long-term natural and artificial selection, yaks ( Bos grunniens ) have evolved diverse coat colors with important aesthetic and economic value. Previous studies indicate that these traits may also serve as important indicators of adaptation to cold, high-altitude environments. However, the …

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Post-Transcriptional Regulatory Network of Non-Coding RNAs in Yaks: Molecular Mechanisms of Hypoxia Adaptation and Productive Traits

关焕玉, Wen Hu, Shuo Zhu, Du’an Chen et autres

Yaks have long inhabited the Qinghai-Tibetan Plateau. This region features low-oxygen, frigid temperatures and pronounced seasonal variation in nutrient availability. They have evolved adaptive phenotypes centered on energy metabolism reprogramming, tissue structure remodeling, and stress homeostasis maintenance. In recent years, non-coding RNAs …

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Regulation of Myogenic Cell Apoptosis, UPS, and Autophagy During Mammalian Skeletal Myogenesis

Binglin Yue, Wen Hu, Shuo Zhu, Du’an Chen et autres

Skeletal myogenesis is an extremely complex process that mononuclear myoblasts undergo proliferation, differentiation, and fusion to form multinucleated contractile muscle fibers, involving a balance between synthesis and degradation metabolism. Skeletal muscle requires an effective mechanism to balance rapid proliferation by degrading supernumerary …

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GAPIT version 4: integration of GWAS into genomic prediction

Jiabo Wang, Zhiwu Zhang

Genomic prediction leverages all available markers, irrespective of their statistical significance in genome-wide association studies (GWAS). Recent advancements in marker density, sample sizes, and sophisticated statistical GWAS methods have demonstrated that integrating GWAS results can potentially boost the accuracy of genomic predictions. …

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Systematic Approach for Compound Angus Populations Revealing Functional Genes and Improving Prediction Accuracy in Carcass Traits

Yuanyuan Yu, Yujiao Fu, Jiahong Zhao, Shiyu Wu et autres

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Transcriptomic Analysis of Skeletal Muscle Systems Comparing Bovines, Humans, and Mice Using scRNA ‐Seq

Cuicui Cai, Xueyao Yang, Hui Wang, Xin Cai et autres

Skeletal muscle is the most widespread tissue in mammals and mediates several functions, and whose development is controlled by a coordinated transcriptional hierarchy that regulates the activities of a range of muscle genes. Skeletal muscle comprises various cells that create communication strategies …

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High-performance edible alginate straws constructed with zein coatings by phase separation and electrostatic assembly after gradient diffusion

Yunpeng Qu, Yuanpu Liu, Kexin Shi, Jiabo Wang et autres

This study developed high-performance, water-resistant edible alginate-based straws by applying a dense zein coating to the surface through controlled phase separation and electrostatic assembly of zein and sodium alginate (SA) following gradient diffusion molding. The zein coating significantly enhanced the anti-swelling properties …

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Large-scale genome sequencing reveals population separation and selection signatures in major canyon yaks

Zemin Li, Jiahong Zhao, Xingyu Guo, Shiyu Wu et autres

Through long-term natural and artificial selection, domestic yaks (Bos grunniens) have diverged from wild ancestors and become vital to high-altitude pastoralism, providing meat, milk, fiber, and other essential resources and transportation. Especially, based on the complex and changeable environments in the canyon …

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Leukocyte Membrane‐Coated Filtrable Micromotors With Selective Distribution of Enzymes for Capturing and Sensing Circulating Tumor Cells

Yixuan Yang, Xia Liu, Lanlan Jia, Jiabo Wang et autres

Enzyme-catalyzed micro/nanomotors exhibit significant promise in drug delivery and sensing due to the exceptional biocompatibility, adaptability, and capacity to employ endogenous fuels. Nevertheless, the flow field generated by the catalytic reaction of enzymes exposed to the outside may considerably impair the recognition …

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Large-scale genome-wide association analysis reveals candidate genes in yak body size traits

Jiahong Zhao, Zehao Li, Xinrui Liu, Yaxin Liu et autres

BACKGROUND: The yak is a unique livestock species bred on the Qinghai-Tibet Plateau. We utilized genotypic data obtained from the yak sequencing chip "Qingxin-1" and phenotypic data measured from image photographs using conversion between pixel and distance. The primary objective of this …

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