Mengqi Li

Zwitterionic PEGylation of Nanodrugs for Reduced Immunogenicity and Improved Drug Delivery Efficacy

Ning Wang, Zhiliang Gao, Mengqi Li, Kangcheng Shen et autres

PEGylated liposomes are widely used as drug delivery carriers due to their prolonged circulation and enhanced accumulation at pathological sites. However, repeated administration can trigger the accelerated blood clearance (ABC) phenomenon, reducing delivery efficacy. Herein, we report a zwitterionic PEGylation strategy by …

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Comparative Study of Biomarkers (PCT, Interleukin-6, Lactate) in Assessing Disease Severity and Organ Dysfunction in Patients with Septic Shock

Yan Peng, Huaiwei Zhang, Mengqi Li

Objective: To investigate the correlations of procalcitonin (PCT), interleukin-6 (IL-6), and lactate (Lac) with disease severity (assessed by APACHE II score) and organ dysfunction in patients with septic shock, and to compare their predictive values. Methods: We prospectively enrolled 320 patients with …

Virtual Reality–Based Social Musical Exergame Guided by Self-Determination Theory for Young Adults With Depression and Anxiety: Protocol for a Randomized Controlled Trial

GuangZheng Wan, Yu Zhang, Mengqi Li

BACKGROUND: Depression and anxiety frequently emerge during late adolescence and young adulthood; however, many conventional and app-based interventions struggle to sustain engagement. Virtual reality (VR) exergaming, music-based activities, and social interaction each show promise for supporting young people's mental health, but their …

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Bipyrimidine‐Boosted Preparation and Post‐Functionalization of Vinylene‐Linked Covalent Organic Frameworks for Sacrificial‐Agent‐Free Photocatalysis of CO 2 Reduction

Xiaomeng Li, Kaiyue Jiang, Mengqi Li, Fancheng Meng et autres

ABSTRACT In nature, photocatalytic reduction of carbon dioxide is a critical process for maintaining the global carbon cycle, which is initiated by the enzymes consisting of chromophoric organic macrocycles in the presence of water. It is extremely desirable to develop an artificial …

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Mapping Research Trends in Traditional Chinese Medicine Exercises for Anxiety Intervention Using a Knowledge Approach

Mengqi Li, Yujing Wei, Zheqian Su

Objective: This study aims to analyze the current status of Traditional Chinese Medicine (TCM) exercises in the intervention of anxiety, identifying research hotspots and future development trends. Methods: The Web of Science database was utilized to conduct a literature review, focusing on …

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Multilayered Nanoarchitectonics of Poly(ethylene glycol) Nanoparticles with Tunable Stiffness Modulate Bio–Nano Interactions and Targeted Drug Delivery

Mengqi Li, Zhiliang Gao, Huiyuan Lv, Kanaparedu P. C. Sekhar et autres

Stiffness, as a crucial physicochemical property of nanoparticles (NPs), has demonstrated a significant impact on bio-nano interactions, including blood circulation, biodistribution, tumor accumulation, and cellular uptake. However, the potential role of NP stiffness in modulating bio-nano interactions to potentiate drug delivery efficacy …

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Vaccination of STING agonists-loaded nanoemulsions for cancer immunotherapy

Xue Ma, Anning Li, Zhiliang Gao, Ning Wang et autres

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Robust optimization for multimodal route planning integrating shared taxi and bus under uncertain traveling time

Rongyan Zhang, Liang Qi, Mengqi Li, Wenjing Luan et autres

Multimodal transportation that integrates multiple transport modes, such as buses, taxis, and subways, plays a crucial role in alleviating environmental pollution and improving mobility. However, unpredictable traffic conditions may disrupt the travel time. This work studies a robust multimodal route planning problem …

Correction to “Hexatopic Vertex-Directed Approach to Vinylene-Linked Covalent Organic Frameworks with Heteroporous Topologies”

Zixing Zhang, Shuai Bi, Fancheng Meng, Xiaomeng Li et autres

Research progress on the mechanism of transcutaneous electrical acupoint stimulation in the perioperative period

Xiaobo Jiang, Mengqi Li, Jing Ying Hu, Xiangmu Gai et autres

Transcutaneous Electrical Acupoint Stimulation (TEAS) is a non-invasive therapeutic approach that combines modern electrophysiological technology with traditional Chinese medicine principles. Over the past few decades, TEAS has become a significant medical intervention during the perioperative period and its mechanisms have seen a …

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Coacervate‐Derived Assembly of Poly(ethylene glycol) Nanoparticles for Combinational Tumor Therapy

Hanru Liu, Huimin Geng, Yuan Tian, Mengqi Li et autres

Coacervates have garnered significant attention as potential drug carriers. However, the instability resulting from their intrinsic membrane-free nature restricts the application of coacervates in drug delivery. Herein, the engineering of poly(ethylene glycol) nanoparticles (PEG NPs) is reported using coacervates composed of PEG …

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Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review

Mengqi Li, Min He, Mengmeng Sun, Yongping Li et autres

Globally, cardiovascular diseases (CVDs) remain the leading cause of death, and their prevention and treatment continue to face major challenges. Oxylipins, as novel circulating markers of cardiovascular disease, are crucial mediators linking cardiovascular risk factors such as inflammation and platelet activation, and …

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