Abhishek Jha

The Stroke Preclinical Assessment Network Multi-laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Mozammel Haque Bhuiyan, Michelle Lin, Carly McCurry, Jessica Lamb et autres

Current translational rodent stroke models induce middle cerebral artery occlusion (MCAo) using nylon filaments, injected emboli, intraluminal thrombin, or perivascular endothelin-1 to simulate human stroke. Among these methods, thromboemboli injection followed by thrombolysis best mimics the neuroinflammatory events seen in human patients …

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Platelet defects in patients and mice with Ehlers-Danlos syndrome

Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Ivan Budnik et autres

ABSTRACT: Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders characterized by joint hypermobility, skin hyperelasticity, perivascular tissue fragility, easy bruising, and increased bleeding risk. Abnormal bleeding in EDS ranges from mild ecchymoses to life-threatening hemorrhage. Platelet function abnormalities have been …

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Platelet dysfunction in Ehlers–Danlos syndrome is associated with low GPVI and PAR1 expression on platelets

Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Ivan Budnik et autres

Abstract Introduction: People with Ehlers–Danlos syndrome (EDS) are at an increased risk for hemorrhagic events, which can range from minor bruising to life-threatening bleeding episodes. Although prior research has suggested the presence of platelet dysfunction in EDS populations, the underlying mechanisms remain …

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HTRS2025.O8A.2 Abstract Travel Award Unraveling Platelet Dysfunction in Ehlers-Danlos Syndrome: Linking Megakaryocyte Abnormalities to Hemorrhagic Risk

Mariia Kumskova, Gagan D. Flora, Manasa K. Nayak, Rakesh B. Patel et autres

Individual and combined effects of ischemic conditioning strategies on infarct size after myocardial ischemia reperfusion

Ahmed Elmahdy, Maryna Krasnikova, Abhishek Jha, Tetiana Pylova et autres

Ischemic preconditioning (PreC), remote perconditioning (PerC), and postconditioning (PostC) are known to reduce myocardial infarct size, but their relative efficacy and potential additive effects remain unclear. This study compared the individual and combined effects of PreC, PerC, and PostC on infarct size …

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Exploring Tetrahydroquinoline Derivatives: A New Frontier in Cancer Treatment

Suman Shaw, Rajdeep Dey, Udit Chaube, Ruchi Yadav et autres

Abstract Tetrahydroquinoline derivatives are emerging as promising anticancer agents due to their versatile biological activities. In this study, we designed, synthesized, and evaluated six novel tetrahydroquinoline derivatives with anticancer potential. The compounds were synthesized by nitration, benzoylation, and reduction, achieving high yields …

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Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial

Rakesh B. Patel, Mariia Kumskova, Hanish Kodali, Ivan Budnik et autres

BACKGROUND: Past failures in translating stroke cerebroprotection provoked calls for a more rigorous methodological approach, leading to the stroke preclinical assessment network SPAN (Stroke Preclinical Assessment Network), where uric acid (UA) treatment exceeded a prespecified efficacy boundary for the primary functional outcome. …

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Morpholine-Substituted Tetrahydroquinoline Derivatives as Potential mTOR Inhibitors: Synthesis, Computational Insights, and Cellular Analysis

Rajdeep Dey, Suman Shaw, Ruchi Yadav, Bhumika Patel et autres

Backgrounds: This study explores the design of substituted tetrahydroquinoline (THQ) derivatives and their synthesis as possible inhibitors of mTOR inhibitors for targeted cancer therapy. Methods: Inspired by the structural characteristics of known mTOR inhibitors, eight novel derivatives were synthesized, characterized using mass …

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Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury

Tetiana Pylova, Ahmed Elmahdy, Maryna Krasnikova, Abhishek Jha et autres

Studies on sex differences in myocardial infarction (MI) typically focus on males versus females, the exploration of hormonal physiologic variations and their impact on the infarct size remains limited. The objective of this study was to examine whether infarct size after myocardial …

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Abstract TMP115: Technical Feasibility and Protocol Compliance in the Second Stroke Pre-Clinical Assessment Network

Patrick D. Lyden, Jenny Johnson, Evan C. Unger, Theo Hagg et autres

Background/Aims: The Stroke Preclinical Assessment Network (SPAN) is a randomized, placebo-controlled, blinded, multi-laboratory preclinical study using a Multi-Arm Multi-Stage statistical design to select one or more putative stroke treatments with an implied high likelihood of success in future human clinical stroke trials. …

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Abstract 162: Imbalanced VWF–ADAMTS13 axis mediates the detrimental impact of preceding bacterial or COVID-19 respiratory tract infections on stroke

Rakeshkumar Patel, Abhishek Jha, Abhishek Verma, Aditi Jain et autres

Background: Preceding respiratory tract infections (RTIs) caused by bacteria or viruses are associated with worse stroke outcomes, likely due to an exaggerated inflammatory immune response, endothelial dysfunction, platelet activation, and coagulopathy. Recent studies have revealed increased plasma von Willebrand factor (VWF) levels …

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Morpholine-Substituted Tetrahydroquinoline Derivatives as Potential mTOR Inhibitors: Synthesis, Computational Insights, and Cellular Analysis

Rajdeep Dey, Suman Shaw, Ruchi Yadav, Bhumika Patel et autres

This study explores the design and synthesis of substituted tetrahydroquinoline (THQ) derivatives as potential mTOR inhibitors for targeted cancer therapy. Inspired by the structural characteristics of known mTOR inhibitors, eight novel derivatives were synthesized, characterized using advanced spectroscopic techniques, and evaluated for …

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