Bing He

Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies

Weiping Cui, Limin Zhang, Chang Yang, Bing He et autres

Therapeutic monoclonal antibodies have revolutionized the treatment of cancers, infectious diseases and immune disorders; however, their efficacy is compromised by limitations associated with systemic administration, including systemic toxicity, poor patient compliance and inadequate drug concentration at pathological sites. Hydrogels are promising carriers …

cn (code pays fourni par la source)

Harness Updating Is Not Harness Benefit: Disentangling Evolution Capabilities in Self-Evolving LLM Agents

Minhua Lin, Juncheng Wu, Zijun Wang, Zhan Shi et autres

LLM agents are increasingly deployed as systems built around editable external harnesses, including prompts, skills, memories and tools, that shape task execution without changing model parameters. Harness self-evolution adapts such agents by updating these harnesses from execution evidence. Yet it remains unclear …

Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunity

Meifang Chen, Xiaojia Jiao, Zhicheng Yan, Yueheng Wang et autres

Metabolic reprogramming targeting the mevalonate pathway represents an emerging innate immune activation target. However, its regulatory mechanisms remain incompletely elucidated. Here, we target the mevalonate pathway and construct a nano-granulated zoledronate (Nano-ZD) modulator. Following subcutaneous injection, Nano-ZD preferentially accumulates in draining lymph …

cn, us (code pays fourni par la source)

Steering Protein Language Models

Long-Kai Huang, Bing He, Jianhua Yao

Protein Language Models (PLMs), pre-trained on extensive evolutionary data from natural proteins, have emerged as indispensable tools for protein design. While powerful, PLMs often struggle to produce proteins with precisely specified functionalities or properties due to inherent challenges in controlling their outputs. …

A nanoscale innate immune multiplier amplifies immunogenic cell death triggered by oxaliplatin via enhancing systemic and trained immunity

Yang Zhang, Zhicheng Yan, Shuo Geng, Yueheng Wang et autres

Inducing immunogenic cell death (ICD) of cancer cells is the key for cytotoxic drugs to improve the synergy with immunotherapy. However, due to the immunosuppressive microenvironment and the cytotoxicity differences of drugs, ICD effects are often insufficient and difficult to effectively and …

cn, us (code pays fourni par la source)

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism

Ming Hu, Wei Xiong, Xingyue Yang, Lu Yu et autres

Introduction: -Tocopherol succinate (VES) together for treating CLI is promising due to their respective effects on regulating bile acid metabolism and providing antioxidant activity. Methods: In this study, we synthesized drug-drug nanocrystals (UA-NSps) composed of UA and VES to treat CLI and …

cn (code pays fourni par la source)

Clinical study on the restoration of anterior tooth defects with zirconia all-ceramic crowns combined with glass fiber posts

Jing He, Bing He

cn (code pays fourni par la source)

Organelle-Level Trafficking and Metabolism Kinetics for Redox-Responsive Paclitaxel Prodrug Nanoparticles Characterized by Experimental and Modeling Analysis

Canyu Yang, Yao Lin Zhao, Yuanyuan Jiao, Long Yang et autres

Redox-responsive self-assembled prodrug nanoparticles have received extensive attention for their high loading efficiency and environmentally responsive properties. However, the intracellular metabolism and transportation kinetics were poorly understood, which limited the rational design and development of this delivery system. Herein, tetraphenylporphyrin-paclitaxel (TxP) prodrugs …

cn, us, Éthiopie (code pays fourni par la source)

Insulator Condition Monitoring Based on TMR Leakage Current Sensors

Bing He, Xiaoyan Sun, Yingyi Liu, Yuhao Li et autres

Traditional overhead transmission line insulator defect detection is generally carried out through manual inspection. The growth in the number of overhead transmission lines has made the inspection scale more massive and the inspection environment more complex, amplifying the shortcomings of the traditional …

cn (code pays fourni par la source)

Engineering supramolecular peptide nanofibers for in vivo platelet-hitchhiking beyond ligand-receptor recognition

Yan Feng, Chenyang Liu, Weiping Cui, Liuqing Yang et autres

Ex vivo or in vivo cell-hitchhiking has emerged as a potential means for efficient drug delivery and various disease therapies. However, many challenges remain, such as the complicated engineering process and dependence on ligand-receptor interaction. Here, we present a simple in vivo …

cn (code pays fourni par la source)

Bisphosphonate-Mineralized Nano-IFNγ Suppresses Residual Tumor Growth Caused by Incomplete Radiofrequency Ablation through Metabolically Remodeling Tumor-Associated Macrophages

Zhicheng Yan, Bing Wang, Yuhan Shen, Junji Ren et autres

Radiofrequency ablation (RFA), as a minimally invasive surgery strategy based on local thermal-killing effect, is widely used in the clinical treatment of multiple solid tumors. Nevertheless, RFA cannot achieve the complete elimination of tumor lesions with larger burden or proximity to blood …

us, cn (code pays fourni par la source)

Impact of Physiological Characteristics on Chylomicron Pathway-Mediated Absorption of Nanocrystals in the Pediatric Population

Xing Wang, Feiyang Deng, Tianyi Ji, Chengning Zhang et autres

Nanocrystals exhibit significant advantages in improving the oral bioavailability of poorly soluble drugs. However, the complicated absorption properties of nanocrystals and the differences in physiological characteristics between children and adults limit pediatric applications of nanocrystals. To elucidate the absorption differences and the …

cn, us (code pays fourni par la source)