Yu Wang

Oxylipins‐Omics Combine With Single‐Molecule Analysis Identifies 13(S)‐HODE Positive Extracellular Vesicles as a Diagnostic Biomarker for AFP‐Negative Hepatocellular Carcinoma

Yu Wang, Qiaoting Wu, Huixian Lin, Xiaoqing Jiang et autres

Efficient diagnostic biomarkers enable early detection of hepatocellular carcinoma (HCC), which improves survival. Circulating extracellular vesicles (EVs) in plasma, as a noninvasive diagnostic carrier, have caused widely concern. Here, a novel oxylipidomic profiling was used to analysis the HCC patients' tissue-derived EVs …

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The LUBAC subunit HOIL-1 promotes the progression of HBV-associated hepatocellular carcinoma independently of linear ubiquitination

Zheyu Dong, Qiuyue Ye, Yuxin Zhou, Junling Chen et autres

The linear ubiquitin chain assembly complex (LUBAC) has been implicated in both cancer progression and viral activity; however, its role in the progression of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC) remains unclear. Here we found that the expression of LUBAC components …

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Predictive value of angiographic microvascular resistance for left ventricular thrombus in anterior ST-segment elevation myocardial infarction

Zhikang Wu, Chunmei Ma, Yu Wang, Guannan Li et autres

Angiographic microvascular resistance (AMR) serves as an effective metric for assessing coronary microvascular status. The aim of this study was to investigate the predictive value of AMR for left ventricular thrombus (LVT) in ST-segment elevation myocardial infarction. This study enrolled 401 consecutive …

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MedS$^3$: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision

Shuyang Jiang, Yusheng Liao, Zhe Chen, Zhang Ya et autres

Medical language models face critical barriers to real-world clinical reasoning applications. However, mainstream efforts, which fall short in task coverage, lack fine-grained supervision for intermediate reasoning steps, and rely on proprietary systems, are still far from a versatile, credible and efficient language …

Distinct Clinical and Biological Characteristics of Acute Myeloid Leukemia With Higher Expression of PIWIL4

Sao Chih Ni, Sheng Yu Hung, Chien Chin Lin, Yu Wang et autres

Clinical outcomes of patients with mut-type methylmalonic acidemia identified through expanded newborn screening in China

Shiying Ling, Shengnan Wu, Ruixue Shuai, Yue Yu et autres

BACKGROUND: Isolated methylmalonic acidemia, an autosomal recessive disorder of propionate metabolism, is usually caused by mutations in the methylmalonyl-CoA mutase gene (mut-type). Because no universal consensus was made on whether mut-type methylmalonic acidemia should be included in newborn screening (NBS), we aimed …

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Improved Quantum Artificial Bee Colony Algorithm-Optimized Artificial Intelligence Models for Suspended Sediment Load Predicting

Peng. Wei, Yu Wang

River sediment plays a critical role in maintaining the health of river ecosystems, and accurately predicting suspended sediment load (SSL) is vital for effective river management. This study proposes a quantum bee colony algorithm based on Boltzmann’s selection and dimensional dynamic update …

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Key environmental factors affecting perceptions of security of night-time walking in neighbourhood streets: A discussion based on fear heat maps

Meng Zhu, Rujie Teng, Canxiang Wang, Yu Wang et autres

Walking plays an important role in residents’ health. After experiencing rapid development, most cities in China have gradually entered the process of urban renewal. Therefore, improving the quality of neighbourhood streets in the old city has become an important issue. The sense …

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Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41

Fan Deng, Liang-Qing Zhang, Han Wu, Yu Chen et autres

Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and its molecular mechanism is urgently needed. Studies have shown that the intestinal flora plays an important regulatory role in cardiovascular injury, but the specific mechanism has not been fully …

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Relationship between salt-inducible kinase 2 (SIK2) and lymph node metastasis in colorectal cancer patients complicated with chronic schistosomiasis

Chao Wu, Yu Wang, Hongliang Gao, Yi Zhang et autres

To investigate the relationship between salt-inducible kinase 2 (SIK2) and lymph node metastasis in colorectal cancer patients complicated with chronic schistosomiasis. Tissue specimens were collected from 363 patients who were diagnosed as colorectal cancer by clinical and pathological examination in Wuhu Second …

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Selenium-oxidizing Agrobacterium sp. T3F4 steadily colonizes in soil promoting selenium uptake by pak choi (Brassica campestris)

Dahui Zhu, Yaxin Niu, Keke Fan, Zhang Fujun et autres

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1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats

Wenjing Zeng, Jing Lv, Yu Wang, Mei-Ling Gao et autres

OBJECTIVES: A previous in vitro study reported that the monoterpene oxide 1,8-cineole (cineole) attenuates neuronal caused by oxygen-glucose deprivation/reoxygenation in culture. However, to date, there is no in vivo evidence showing neuroprotective effects of cineole against stroke. This study aimed to investigate …

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