Jigang Wang

STK11 c.1062 C > G germline variant in medullary thyroid carcinoma: implications for familial predisposition and genetic counseling

Weimao Kong, Longnv Bao, Meili Wang, Xiangzhong Zhao et autres

cn (code pays fourni par la source)

Distantly metastatic differentiated thyroid carcinoma is kinase‐driven and enriched for DNA repair and DNA methylation gene alterations

Weimao Kong, L Bao, Jianxia Hu, Guangqi Li et autres

Although distant metastasis is uncommon in differentiated thyroid carcinoma (DTC), it remains the leading cause of thyroid cancer-related mortality. The genetic landscape of distantly metastatic DTC (DMDTC) has not been well characterized in large cohorts. This study aimed to identify functional genetic …

cn (code pays fourni par la source)

Rosmarinic Acid Suppresses Keap1/Nrf2 Signaling Pathway via Targeting USP15 to Attenuate Myocardial Ischemia/Reperfusion Injury

Hui Zhao, Shujie Zhang, Ying Zhang, Ang Ma et autres

Myocardial ischemia-reperfusion injury (MI/RI) is a complication following the treatment of acute myocardial infarction. Although rosmarinic acid (RA) possesses potent antioxidant properties, its specific targets and mechanisms underlying its therapeutic effect against MI/RI remain unclear. Our study found that RA has therapeutic …

cn, us (code pays fourni par la source)

Synergistic gambogic acid/Ga³⁺ remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy

Chong Qiu, Pengbo Guo, Chen Wang, Qingchao Tu et autres

The immunosuppressive tumor microenvironment (TME) is a pivotal contributor to therapeutic resistance in triple-negative breast cancer (TNBC). Immunogenic cell death (ICD), which activates antitumor immunity through damage-associated molecular pattern (DAMP) release, represents a promising therapeutic strategy for TNBC. Although gambogic acid (GA) …

cn (code pays fourni par la source)

Clinicopathological characterization of female genital tract cancers with STK11 alterations: redefining the spectrum beyond STK11 adnexal tumors

Weimao Kong, Xingzhu Pan, Jigang Wang

cn (code pays fourni par la source)

Shangke Jiegu tablet enhances callus formation during fracture repair by promoting angiogenesis-osteogenesis coupling via PTGS2-PGE2/EP4 axis

Lin Chen, Chuhan Zhang, Xiaojie Li, Jingyuan Zhang et autres

cn (code pays fourni par la source)

Engineering anti-inflammatory magnesium-mangiferin hydrogel for diabetic wound healing

Ling Huang, Fei Xia, Pengbo Guo, Qingchao Tu et autres

Excessive inflammation and impaired vascularization are hallmark features of diabetic wounds, contributing significantly to the failure of the wound healing process. Hence, effective therapies must simultaneously dampen inflammation and restore angiogenesis. Current wound dressings often involve intricate fabrication processes and rely on …

cn (code pays fourni par la source)

DICER1 mutations in Bethesda category II, III, and IV thyroid nodules: A mutually exclusive relationship with BRAF V600E mutation

Yulian Wang, Guangqi Li, Weimao Kong, Jianxia Hu et autres

Abstract Background This study aimed to investigate the prevalence and cytological features of Dicer 1 , Ribonuclease III ( DICER )‐mutant fine‐needle aspiration (FNA) specimens in thyroid nodules classified as Bethesda II, III, and IV categories. The authors also sought to explore …

cn (code pays fourni par la source)

An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis

Ben K. S. Hu, Huimin Lin, Xiaolong Quan, Fushan Sun et autres

cn, fr (code pays fourni par la source)

Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer

Qixiang Shi, Huiying Li, Peili Wang, Fuchao Chen et autres

cn (code pays fourni par la source)

Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: BEND7::ALK, DLG5::RET, and CCDC30::ROS1 Fusions Induce MAPK Pathway Activation

Yixuan Liu, Guangqi Li, Weimao Kong, Xueqing Li et autres

cn (code pays fourni par la source)

Multimodal lung cancer theranostics via manganese phosphate/quercetin particle

Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang et autres

The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on the patient’s condition and drive-up treatment costs. …

cn (code pays fourni par la source)