Wenguang Wang

Virus-mimicking nanoparticle potentiates in-situ cancer vaccines by reversing intratumoral DCs via stimulating cytosolic nucleic acid sensors

Ya Chu, Luyao Wang, Xi Xiao Huang, Lin Luo et autres

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Self-assembly nanoparticles potentiate in-situ tumor vaccine of radiotherapy by regulating tumor immunogenicity and tumor-associated macrophages

Shuqian Ma, Kaiyuan Hu, Junjie Xue, Di Wu et autres

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Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria

Wenguang Wang, Haiheng Xu, Qingsong Ye, Feng Tao et autres

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Molecular cloning and characterization of NPC1L1 in the Chinese tree shrew (Tupaia belangeri chinensis)

Xiuying Kui, Dandan Qiu, Wenguang Wang, Na Li et autres

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Comparing the hippocampal miRNA expression profiles of wild and domesticated Chinese tree shrews (Tupaia belangeri chinensis)

Caixia Lü, Mingxue Li, Xiaomei Sun, Na Li et autres

BACKGROUND: The domestication of tree shrews represents an important advance in the development of standardized laboratory animals. Little is known regarding the miRNA changes that accompany the transformation of wild tree shrews into domestic tree shrews. RESULTS: By performing miRNA-seq analysis on …

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miR-106a-5p Functions as a Tumor Suppressor by Targeting VEGFA in Renal Cell Carcinoma

Jun Ma, Wenguang Wang, Baihetiya Azhati, Yujie Wang et autres

MicroRNAs (miRNAs) regulate progression of different cancers. Nevertheless, there is limited information regarding the role of miR-106a-5p in renal cell carcinoma (RCC). Herein, we demonstrate that miR-106a-5p levels are drastically decreased in clear cell RCC (ccRCC) tissues and cell lines, which subsequently …

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长链非编码RNA SNHG3在食管鳞状细胞癌中的表达及其对ECA-109细胞迁移和侵袭的影响

郭晓锋, Guo Xiaofeng, 朱曼, Man Zhu et autres

目的 探究长链非编码RNA SNHG3在食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）组织中的表达及其对ECA-109细胞迁移和侵袭的影响。 方法 收集安阳市肿瘤医院2011年6月到2014年6月收治的60例ESCC患者癌及对应癌旁组织样本，采用qRT-PCR检测ESCC癌与癌旁组织、ESCC细胞ECA-109和人正常食管上皮细胞HEEC中lncRNA SNHG3的表达水平，分析ESCC患者组织中lncRNA SNHG3的表达与ESCC患者临床特征的关系。采用siRNA-SNHG3质粒转染ECA-109细胞，以敲降lncRNA SNHG3的表达水平。采用Kaplan-Meier法分析lncRNA SNHG3表达与患者预后的关系。采用Transwell实验检测ECA-109细胞的迁移和侵袭能力。采用qRT-PCR和Western blot实验检测ECA-109细胞中SNAIL和TWIST的mRNA及蛋白的表达水平。 结果 ESCC肿瘤组织中lncRNA SNHG3的表达水平显著高于癌旁组织（P 结论 lncRNA SNHG3在ESCC肿瘤组织和细胞中高表达，通过调控SNAIL和TWIST蛋白的表达，促进ECA-109细胞的迁移和侵袭。

RETRACTED ARTICLE: The long noncoding RNA linc00858 promotes progress of lung cancer through miR-3182/MMP2 axis

Mingqiang Xue, Dongfeng Shi, Guanghui Xu, Wenguang Wang

In previous studies, numerous dysregulated lncRNAs were identified using RNA-sequencing. Lung cancer is the most common malignant tumour worldwide and the second leading cause in cancer. The aim of this study is to investigate the function and mechanism of lincRNA00858 in the …

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Conjugational delivery of chromosomal integrative constructs for gene expression in the carbendazim-degrading Rhodococcus erythropolis D-1

Tao Yang, Wenguang Wang, Sheng-Hui Lu, Xin Xie et autres

Rhodococcus strains not only have been widely used in industries but also have a potential ability of producing new structural natural products. Integration of heterologous genes into chromosomes of Rhodococcus strains for gene expression can facilitate the studies and applications of these …

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High glucose contributes to the proliferation and migration of non-small-cell lung cancer cells via GAS5-TRIB3 axis

Chengzhi Ding, Xufeng Guo, Guolei Wang, Hong-Tao Wang et autres

Despite the growing number of studies exhibited an association of diabetes mellitus (DM) and lung cancer progression, the concrete mechanism of DM aggravating lung cancer has not been elucidated. This study was to investigate whether and how high glucose (HG) contribute to …

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Culture and Identification of Mouse Bone Marrow-Derived Dendritic Cells and Their Capability to Induce T Lymphocyte Proliferation

Wenguang Wang, Jia Li, Kun Wu, Baihetiya Azhati et autres

BACKGROUND: The aim of this study was to establish a culture method for mouse dendritic cells (DCs) in vitro and observe their morphology at different growth stages and their ability to induce the proliferation of T lymphocytes. MATERIAL/METHODS: Granulocyte-macrophage colony stimulating factor …

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Analysis of the molecular characteristics and cloning of full-length coding sequence of Interleukin-2 in tree shrews

Xiaoyan Huang, Mingli Li, Juan Xu, Yue‐Dong Gao et autres

While the tree shrew (Tupaia belangeri chinensis) is an excellent animal model for studying the mechanisms of human diseases, but few studies examine interleukin-2 (IL-2), an important immune factor in disease model evaluation. In this study, a 465 bp of the full-length …

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