Dongming Zhang

CACNA1C variants associated with focal epilepsy and their correlations with arrhythmias and developmental disorders

Yan‐Fang Li, Pei Mo, Lan-Zhen Zhang, Xinlong Zhou et autres

Purpose CACNA1C variants have been identified in cardiac arrhythmias and developmental disorders (DD). Here, we aimed to explore the association between CACNA1C and epilepsy and the mechanism underlying phenotypic heterogeneity. Methods Trio-based whole-exome sequencing was performed in patients with focal epilepsy. Genes …

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Innovative co-fermentation of Propionibacterium freudenreichii and Rhizopus oryzae enhances vitamin B12, riboflavin, and flavor profile components in sweet fermented glutinous rice

Ruoxi Zhang, Liye Chen, Dongming Zhang, Jenni Sihvola et autres

This study explores nutritional and sensory enhancement via co-fermentation of Propionibacterium freudenreichii (DSM 20271; J117) and Rhizopus oryzae (Angel Yeast Co., Ltd. starter) in sweet fermented glutinous rice (SFGR). After 72-h fermentation, the co-culture significantly increased vitamin B12 (15 ng/mL) and riboflavin …

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Dapagliflozin regulates kynurenine metabolism and microglial activation to alleviate diabetes-associated cognitive impairment

Yan Jia, Jiangxia Pang, Chen Sun, Puyun Wang et autres

Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has shown significant therapeutic potential in alleviating Diabetes-associated cognitive dysfunction (DACD). However, its specific effects on microglia remain to be further explored. In this study, a type 2 diabetes mellitus (T2DM) mouse model induced by …

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Design, synthesis, and biological evaluation of 7-O-methyesculin esters as potent inhibitors of renal fibrosis

Haowen Luo, Xinyi Chen, Haijie Wu, Chuang‐Jun Li et autres

Renal fibrosis is a global health challenge with limited therapies. 7-O-methyesculin (7-ME), derived from Cortex Fraxini (Qinpi), shows notable anti-inflammatory and anti-fibrotic properties. To enhance its membrane permeability and biological activity, we performed structural optimization and synthesized 18 6’-O-acyl 7-ME esters to …

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Modulation of growth, gut-liver axis, and antioxidant defense by Bacillus tequilensis (GCB-3) in grass carp (Ctenopharyngodon idella) under high-carbohydrate diet: Insights into health enhancement and oxidative stress mitigation

Xin Wang, Dongming Zhang, Xinping Zhang, Xinyu Lei et autres

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List of contributors

Tanvir Ahmed, Ahmed A. Al-Karmalawy, Feifei An, Ömer Aras et autres

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Dietary supplementation with host gut-derived Bacillus tequilensis (GCB-3) enhances growth, immune function, antioxidant capacity, and resistance to poly(I: C)-induced viral infection in grass carp (Ctenopharyngodon idella)

Xin Wang, Bowen Li, Xinyu Lei, Lili Lin et autres

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Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model

Khosrow Mohammadi, Dongming Zhang, Per E. J. Saris

The gut microbiota is increasingly recognized as a key contributor to intestinal and brain pathologies, including Parkinson's disease (PD). Sulfate-reducing Desulfovibrio (DSV) species have emerged as microbial drivers through hydrogen sulfide and other neurotoxic factors. Using the Caenorhabditis elegans PD model NL5901 …

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Variants in CSMD2 and CSMD3 , genes involved in synaptogenesis, are associated with epilepsies

Xiang Li, Lin Wang, Xiaoyu Liang, Hongwei Zhang et autres

OBJECTIVE: The CSMD genes, including CSMD1, CSMD2, and CSMD3, encoding synaptic transmembrane proteins, play important roles in neuronal maturation, growth of dendrites, and processes of synapses. Our recent study showed that CSMD1 was associated with developmental epileptic encephalopathy (DEE) and generalized epilepsy. …

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Bioactive diterpenoids from the leaves of Callicarpa formosana Rolfe

Panpan Gao, Yulu Tian, Haowen Luo, Jie Ma et autres

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Integrated multiple-omics reveals the regulatory mechanism underlying the effects of homologous Bacillus tequilensis (GCB-3) on growth performance of grass carp (Ctenopharyngodon idellus)

Xin Wang, Dongming Zhang, Xinping Zhang, Xinyu Lei et autres

The purpose of this study was to investigate the regulatory mechanism of Bacillus tequilensis (GCB-3) in improving the growth performance of grass carp by microbiome and targeted metabolomics analysis. Fish were fed with different amounts of GCB-3 including B0 (0 CFU/g), B6 …

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L-Carnitine Can Promote the Growth Performance of Rotifers (Brachionus Rotundiformis) by Improving Their Feeding Behavior and Nutrient Composition

Yongsheng Gao, Fayou Liu, Xinping Zhang, Sibu Wang et autres

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