Jingjing Ma

Isavuconazole for invasive mold disease in patients with hematological malignancies: a multicenter real-world study from China on efficacy, safety, and competing risks

Jirui Zhang, Mengying Xu, Jiaojiao Mao, Jingjing Ma et autres

ABSTRACT Isavuconazole is approved for invasive aspergillosis (IA) and mucormycosis, but real-world data in patients with hematological malignancies are limited. This retrospective study (2022–2025) included adult patients with hematological malignancies and proven/probable invasive mold disease (IMD) who were treated with isavuconazole for …

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Ezetimibe mitigates microglial activation in Parkinson’s disease via TLR4/JNK pathway inhibition: evidence from network pharmacology and experimental validation

Xinyue Huang, Jingjing Ma, Jin Wu

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Dual-source DPP4 drives intestinal fibrosis in Crohn’s disease: synergistic therapeutic targeting of host and microbiota pathways

Jiajia Li, Ying Xu, Mingyuan Wang, Junjie Lin et autres

Crohn’s disease (CD), a chronic inflammatory bowel disorder, often progresses to intestinal fibrosis and stricture, yet no effective anti-fibrotic treatments exist. This study reveals dipeptidyl peptidase 4 (DPP4) as a pivotal driver of fibrosis through bioinformatics analysis, clinical samples, and experimental models. …

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Effect of preoperative intranasal dexmedetomidine versus placebo on intraoperative shivering in parturients undergoing cesarean section: a randomized controlled trial

Guolin Xu, Yong Ding, Jingjing Ma, Rui Li

Background Shivering during cesarean section under epidural anesthesia is common and may negatively affect maternal comfort, surgical conditions, and physiological stability. This single-blinded, randomized controlled trial evaluated whether preoperative intranasal dexmedetomidine reduces the incidence of shivering in parturients undergoing cesarean delivery. Methods …

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Efficacy and safety of three methods of endoscopic retrograde cholangiopancreatography in removing small common bile duct stones: a prospective multicenter randomized controlled study

Ye Qiang, Jin Zhang, Jun Yao, Qiang Zhan et autres

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Global, regional, and national burden of Hodgkin lymphoma, 1990–2021, and predictions for 2050: an analysis of the global burden of disease study 2021

Dongnan Li, Yunjie Li, Yue Chen, Qiuni Chen et autres

Background Hodgkin lymphoma (HL), a lymphoid malignancy with bimodal age incidence, was analyzed across 204 countries (1990-2021) using data from the global burden of disease (GBD) 2021, with projections till 2050.Research design and methods Using GBD 2021 data, we assessed HL burden …

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Sex disparities in receipt of layperson bystander cardiopulmonary resuscitation and survival for adults who experienced out-of-hospital cardiac arrest in China

Jingjing Ma, Chunxia Cao, Yue Li, Yohei Okada et autres

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Supply chain risk management with blockchain: A literature review and future research directions

Chen Li, Muhammad Shabir Shaharudin, Bing Wei, Jingjing Ma

Coronavirus Disease 2019 (COVID-19) has put tremendous pressure on global supply chain risk management (SCRM). Recent technological advances, especially blockchain technology (BCT), a leader in distributed digital technology with its traceability, transparency, immutability, and district-centralization features, have shown some success in several …

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Inflammatory monocyte-derived amphiregulin mediates intestinal fibrosis in Crohn’s disease by activating PI3K/AKT

Shu Wang, Lu Wang, Junjie Lin, Mingyuan Wang et autres

Intestinal fibrosis is one of the most threatening complications of Crohn's disease (CD). Although our previous study identified the profibrotic role of amphiregulin (AREG) in intestinal fibrosis, the underlying molecular mechanisms remain poorly understood. This study aimed to elucidate the mechanisms by …

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Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease

Lu Wang, Shu Wang, Junjie Lin, Jiajia Li et autres

Abstract Background Intestinal fibrosis is a serious complication of Crohn’s disease (CD), often resulting from chronic inflammation. However, the precise mechanisms through which inflammation induces intestinal fibrosis remain inadequately elucidated. Methods A comprehensive single-cell atlas of full-thickness CD, provided by Dr. Florian …

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Recent research progress on the biological functions, synthesis and applications of selenium nanoparticles

Chunxia Chen, Jingjing Ma, Weiqi Xie, Zhizeng Wang

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Prognostic and clinical value of serum albumin, cortisol and TNF-a in treatment selection for advanced ovarian cancer patients

Rong Jiang, Xin Pan, Xiu Shi, Jinhua Zhou et autres

Background: This study aimed to evaluate the prognostic significance of pre-treatment serum albumin levels and assess their association with clinical outcomes and surgical decisions in advanced ovarian cancer (O C) patients. Cortisol and tumour necrosis factor-alpha (TN F-a) were also measured to …

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