Pengfei Zhao

Atrophy of the cochlear aperture segment of the cochlear nerve in patients with severe-to-profound acquired sensorineural hearing loss: a 5-T MRI study

Siwei Yang, Shengmei Ma, Yan Huang, Furen Guo et autres

OBJECTIVES: Cochlear nerve (CN) atrophy is a prognostic marker for cochlear implantation outcomes in acquired sensorineural hearing loss (ASNHL). However, conventional MRI confines assessment to the nerve trunk. This 5-T MRI study aimed to assess the feasibility of visualizing the cochlear aperture …

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Hemodynamic and morphologic adaptations of the dural venous sinus to 7-day −6° head-down tilt and recovery: an eight-timepoint 4D flow MRI longitudinal study

Zhanxin Wu, Huanran Hou, Y Q Huang, Guo F et autres

Cephalad fluid shift during microgravity may disrupt intracranial fluid homeostasis. However, longitudinal quantitative data characterizing intracranial dural venous sinus adaptation to these fluid shifts remain limited. We conducted a prospective cohort study of 38 healthy adult men undergoing 7-day −6° head-down tilt …

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Preliminary Anti-Melanoma Activity of a Chlorogenic Acid-Based PROTAC Targeting MDM4, a Candidate Protein Identified by Proteomics

Zhiting Mei, Jian Sun, Pengfei Zhao, Yiming Luo et autres

Chlorogenic acid (CGA), which is ubiquitous in diverse botanical sources, demonstrates considerable anticancer potential through modulation of multiple targets or signaling pathways, thereby posing substantial challenges for mechanistic elucidation and target identification. Based on the proteolysis targeting chimera (PROTAC) technology’s ability to …

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Nano-GlycOTAC eradicates Mycobacterium tuberculosis biofilms and rectifies iron metabolism to augment host antimicrobial immunity

Zhuojun He, Deliang Liu, Yao Zhao, Guiqin Dai et autres

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Cumulative blood pressure exposure and cognition: the potential mediating role of brain volume

Xiaoshuai Li, Zejun Zhu, Ying Hui, Huijing Shi et autres

Elevated blood pressure (BP) has been linked to brain structure changes and cognitive decline. However, few studies have accounted for long-term cumulative BP exposure. We investigated the association between cumulative BP exposure, brain volume, cerebral blood flow (CBF), and cognitive decline. Furthermore, …

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Systolic Blood Pressure Time in Target Range and Cerebral Small Vessel Disease

Guanming Ji, Mengmeng Bai, Huijing Shi, Ling Yang et autres

Abstract BACKGROUND Whether systolic blood pressure (SBP) time in target range (TTR) associates with cerebral small vessel disease (CSVD) in hypertensive patients remains unclear. METHODS Between December 2020 and August 2023, participants were prospectively included from the Kailuan study. TTR was calculated …

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Condylar alteration in three subtypes of temporomandibular disorder based on U-HRCT: a cross-sectional study

Ruowei Tang, Wen Chen, Ning Xu, Xiaoqing Yuan et autres

BACKGROUND: To investigate osseous remodeling pattern of the condyle across different subtypes of temporomandibular disorder (TMD) using 3D model generated from ultra-high-resolution CT (U-HRCT). METHODS: This single-center, retrospective study enrolled patients with unilateral TMD who underwent both U-HRCT and magnetic resonance imaging …

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Hub, Bridge, or Channel? Role Selection and Evolution of Urban Green Innovation Networks Under Climate Risk

Pengfei Zhao, Qingfeng Luo

Physical climate risks are reshaping economic geography and pose a direct threat to the collaborative networks of green innovation that underpin mitigation and adaptation. This paper examines how climate risk differentially affects three core structural roles that cities occupy in green innovation …

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[Efficacy of malleostapedotomy for congenital ossicular malformation and influencing factors of postoperative hearing outcomes].

Z R Chen, Ruowei Tang, N Xu, Jing Xie et autres

MS surgery has a safe and reliable curative effect on patients with congenital ossicular malformations. As long as the insertion depth and angle of Piston are within a certain reasonable range, their impact on postoperative hearing is not significant. There is a …

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[Researches and clinical translation of smart dressings].

Guozhong Lyu, Pengfei Zhao

The research and application of smart dressings are a focal point in fields such as burn and wound repair. Breakthroughs in miniaturized electronic components, fiber optics and wireless communication technologies, and flexible circuit, and the research and development of novel biomaterials have …

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Analysis of perioperative mortality in 66 patients with head and neck cancer: A retrospective study

Pengfei Zhao, Xinyi Lin, Wei Li, Yiming Chen

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Evaluating the impact of sigmoid sinus wall reconstruction on pulsatile tinnitus treatment Outcomes: A longitudinal follow-up study

Chihang Dai, Shengmei Ma, Heyu Ding, Xiaoyu Qiu et autres

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