Xin Zhao

Heterogeneous Biological Responses to Low-Level Sodium Saccharin Exposure: An Integrated Computational Toxicology and Mendelian Randomization Study

Xin Zhao, Yanchun Wang, Chen Xinwang, Xuemei Wang

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses associated with sodium saccharin across multiple cancer outcomes. Methods Public databases were screened to identify saccharin-related …

cn (code pays fourni par la source)

MiR-23a represses CELF1 to modulate buffalo granulosa cell apoptosis and steroidogenesis via the PI3K/AKT pathway

Xin Zhao, Penglei Shen, Deshun Shi, Fenghua Lu

MicroRNAs (miRNAs) are critical regulators of mammalian follicle development. Our previous work showed that miR-23a expression was significantly higher in buffalo oocytes at metaphase II (MII) than at the germinal vesicle (GV) stage, implying a role in oocyte maturation. Here, we investigated …

cn (code pays fourni par la source)

Re: Emmeli Palmstedt, Marianne Månsson, Jonas Hugosson, Rebecka Arnsrud Godtman. Active Surveillance for Screen-detected Low- and Intermediate-risk Prostate Cancer: Extended Follow-up up to 25 Years in the GÖTEBORG-1 Trial. Eur Urol. 2025;88:373–380

Ziheng Wang, Xuenan Li, Xin Zhao, Yi Yang

cn (code pays fourni par la source)

Efficacy and safety of ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma at specific anatomic sites of the liver: a systematic review and meta-analysis

Yongsheng Fu, Qicong Zhu, Xin Zhao, Jingfen Lu et autres

OBJECTIVE: This meta-analysis aims to evaluate the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for hepatocellular carcinoma (HCC) located at specific anatomical sites of the liver compared with non-specific sites. METHODS: A systematic search was conducted across five databases, covering …

cn (code pays fourni par la source)

[Hypoandrogenism and the mode of cell death in the penile cavernosum tissue of male rats].

Xin Zhao, Jing Li, Rui Jiang

OBJECTIVE: To study the mode of cell death in the penile cavernosum tissue of male rats in the hypoandrogenic state. METHODS: We equally randomized 36 10-week-old SD male rats into six groups: 4-week sham-operation (4-wk SO), 8-week sham-operation (8-wk SO), 4-week castration …

cn (code pays fourni par la source)

Regulation of calcium homeostasis in endoplasmic reticulum–mitochondria crosstalk: implications for skeletal muscle atrophy

Xuexin Li, Xin Zhao, Zhengshan Qin, Jie Li et autres

This review comprehensively explores the critical role of calcium as an essential small-molecule biomessenger in skeletal muscle function. Calcium is vital for both regulating muscle excitation-contraction coupling and for the development, maintenance, and regeneration of muscle cells. The orchestrated release of calcium …

cn (code pays fourni par la source)

Efficacy and Safety of Berberine in Treating Type 2 Diabetes Mellitus: a Bayesian Network Meta-Analysis

Adili Tuersun, Xin Zhao, Liyuan Pang, Xiaobo Sharon Hu et autres

cn (code pays fourni par la source)

Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway

Wenjie Yin, Xin Zhao, Muli Xu, Peijin Wang et autres

cn (code pays fourni par la source)

Gynostemma Pentaphyllum ameliorates CCl4-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics

Linlan Hu, Xin Zhao, Xian He, Yafei Guo et autres

Abstract Background Gynostemma pentaphyllum (Thunb.) Makino, commonly known as “southern ginseng”, contains high amounts of ginsenoside derivatives and exhibits similar biological activities with Panax ginseng (C. A. MEY) (ginseng), which is usually used as a low-cost alternative to ginseng. G. pentaphyllum has …

cn (code pays fourni par la source)

Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial

Jon Griffin, Jenny Down, Lewis A. Quayle, Paul R. Heath et autres

The GUSTO clinical trial (Gene expression subtypes of Urothelial carcinoma: Stratified Treatment and Oncological outcomes) uses molecular subtypes to guide neoadjuvant therapies in participants with muscle-invasive bladder cancer (MIBC). Before commencing the GUSTO trial, we needed to determine the reliability of a …

gb, us (code pays fourni par la source)

FUNDC1-induced mitophagy protects spinal cord neurons against ischemic injury

Dehui Chen, Linquan Zhou, Gang Chen, Taotao Lin et autres

Local ischemia and hypoxia are the most important pathological processes in the early phase of secondary spinal cord injury (SCI), in which mitochondria are the main target of ischemic injury. Mitochondrial autophagy, also known as mitophagy, acts as a selective autophagy that …

cn (code pays fourni par la source)

Low androgen levels induce ferroptosis of rat penile cavernous endothelial cells

Hongxing Shi, Xin Zhao, Haifan Yang, Yong Cheng et autres

Abstract Background Endothelial dysfunction caused by low androgen levels in penile tissue can lead to erectile dysfunction. The exact mechanism of endothelial dysfunction has not been thoroughly studied. Objective The study sought to verify whether low androgen levels induce ferroptosis of endothelial …

cn (code pays fourni par la source)