Jinghui Liu

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu et autres

OBJECTIVE: CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in …

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HOXB13 as a Lineage-Restricted Chromatin Regulator Linking Androgen Signaling, Epigenetic Remodeling, Metabolic Reprogramming, and Kinase Signaling in Prostate Cancer Progression

Mansoureh Nouri, Hamed Maasoumyhaghighi, Xiaoqi Liu, Jinghui Liu

Prostate cancer progression is shaped by dynamic interactions among lineage identity, androgen receptor signaling, chromatin organization, metabolic adaptation, and therapy-induced plasticity. HOXB13 is a prostate-enriched homeobox transcription factor classically recognized for its roles in prostate development, androgen receptor transcriptional regulation, and hereditary …

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830 PLK1 MAINTAINS INTESTINAL EPITHELIAL INTEGRITY AND RESTRAINS INFLAMMATION-DRIVEN TUMORIGENESIS BY COORDINATING STEM CELL RENEWAL AND CYTOKINE NETWORK SUPPRESSION

Xinyi Wang, Jinghui Liu, Jia Peng, Sai Wu et autres

830 PLK1 MAINTAINS INTESTINAL EPITHELIAL INTEGRITY AND RESTRAINS INFLAMMATION-DRIVEN TUMORIGENESIS BY COORDINATING STEM CELL RENEWAL AND CYTOKINE NETWORK SUPPRESSION

Xinyi Wang, Jinghui Liu, Jia Peng, Sai Wu et autres

Intestinal barrier heterogeneity mediates intestinal health advantage of baling Tieshan organic bighead carp

Zhen Huang, Chigang Huang, Yizhen Wang, Shuxia Yao et autres

cn (code pays fourni par la source)

Molecular engineering approaches to half-life extension of therapeutic biomolecules

Y. WANG, Junliang Chang, Jinghui Liu

half-lives due to rapid renal filtration, proteolytic degradation, and immune clearance. Short half-life leads to frequent dosing, fluctuation in blood drug concentration, and increased treatment costs, severely limiting clinical efficacy. To address these challenges, various half-life extension strategies have been developed, including …

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Abstract 6617: Targeting the PLK1-PRMT5 axis enhances radiosensitivity in prostate cancer.

Jia Peng, Xinyi Wang, Daheng He, Jianlin Wang et autres

Abstract Prostate cancer remains the most frequently diagnosed cancer and the second leading cause of cancer-related death among men in the United States. We previously demonstrated that Polo-like kinase 1 (PLK1) phosphorylates PRMT5 at the S470 site, a modification required to maintain …

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Abstract 5965: Plk1-BRN2 signaling axis drives lineage plasticity in castration-resistant prostate cancer

Fatemeh Seilani, Meng Wu, Jia Peng, Mohammad Esfini Farahani et autres

Abstract Prostate cancer frequently acquires resistance to androgen receptor (AR)-targeted therapies through lineage plasticity, leading to neuroendocrine prostate cancer (NEPC), an aggressive and therapy-resistant subtype. BRN2 (POU3F2) is a key transcription factor that drives this transition and is normally repressed by AR …

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Mapping the global research landscape and innovations on elderly glioma: a bibliometric analysis

Shaochun Guo, Wenbo Zhao, Jinghui Liu, Na Wang et autres

Objective: Glioma demonstrates age-specific molecular profiles and heightened aggressiveness in older adults, yet research remains predominantly focused on younger populations. Amid global aging and rising incidence, tailored therapeutic strategies for elderly patients are urgently needed. This study provides a comprehensive bibliometric analysis …

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Polystyrene Microsphere-Labeled Lateral Flow Assay for the Visual Detection of Foodborne Pathogens

Lingmei Zhang, Wanwei Qiu, Lu Lu, Jinghui Liu et autres

With the increasing emphasis on food safety and health, it has become particularly important to develop rapid, sensitive and low-cost detection methods for foodborne pathogens. Lateral flow assay (LFA) has shown great potential in the field of point-of-care testing (POCT) due to …

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Injury-induced electrochemical coupling triggers organ growth

Jinghui Liu, Elisa Nerli, Charlie Duclut, Amit Singh Vishen et autres

Organ injury triggers nonneuronal electric currents essential for regeneration. However, the mechanisms by which electrical signals are generated, sensed, and transmitted upon damage to promote organ growth remain unclear. Here, we uncover that organ repair relies on dynamic electrochemical coupling between membrane …

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Selective excitation of work-generating cycles in non-reciprocal living solids

Yu-Chen Chao, Shreyas Gokhale, Lisa Lin, Alasdair Hastewell et autres

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