Chao Ren

Camrelizumab plus nimotuzumab as second-line therapy for advanced esophageal squamous cell carcinoma: a multicenter phase II study

Jin Xia, Xiangrui Meng, Guozhong Jiang, Yonggui Hong et autres

Background Therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) after first-line failure remain limited, particularly in patients previously exposed to immune checkpoint inhibitors (ICIs). We evaluated the efficacy, safety, and exploratory biomarker correlates of camrelizumab, an ICI, combined with nimotuzumab, an …

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Circulating tumour DNA to guide rechallenge with cetuximab plus irinotecan in RAS/BRAF wild‐type metastatic colorectal cancer: A nonrandomised clinical trial

De‐Shen Wang, W C Chen, Chao Ren, Feng‐Hua Wang et autres

Abstract Background Mutant subclones driving anti‐EGFR resistance may progressively decline after therapy cessation, potentially reversing resistance to EGFR‐targeted treatment. We therefore examined whether rechallenge with cetuximab plus irinotecan is active and tolerable in patients selected by circulating tumour DNA (ctDNA) testing, focusing …

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Author Correction: A circRNA signature predicts postoperative recurrence in stage II/III colon cancer

Huai‐Qiang Ju, Qi Zhao, Feng Wang, Ping Lan et autres

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Sintilimab plus cisplatin and nab‐paclitaxel induction treatment for locally advanced borderline‐resectable oesophageal squamous cell carcinoma: A single‐arm, prospective, phase 2 study (NEOCRTEC2001)

Jiadi Wu, De‐Shen Wang, Zi Wang, Qiao‐Qiao Li et autres

BACKGROUND: The standard treatment for locally advanced borderline-resectable esophageal squamous cell carcinoma (BR-ESCC) is still debated owing to insufficient evidence from clinical trials. An increasing number of clinical studies focus on investigating the use of immunotherapy in the treatment of oesophageal cancer. …

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Abstract CT150: Sintilimab plus cisplatin and nab-paclitaxel induction treatment for locally advanced borderline resectable esophageal squamous cell carcinoma: A single-arm, prospective, phase 2 study (NEOCRTEC2001)

Xin Zhang, Jiadi Wu, Deshen Wang, Zi Wang et autres

Abstract Background: The standard treatment for locally advanced borderline-resectable esophageal squamous cell carcinoma (BR-ESCC) is still debated owing to insufficient evidence from clinical trials. An increasing number of clinical studies focus on investigating the use of immunotherapy in the treatment of esophageal …

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A case report of SMARCA4-deficient undifferentiated gastric carcinoma diagnosed by endoscopic ultrasound-guided fine needle aspiration

Yuehua Chen, Chao Ren, Peifei Shi

Gastric SMARCA4-deficient undifferentiated carcinoma is an exceptionally rare and highly aggressive malignancy characterized by loss of SMARCA4 expression. Due to its rarity and nonspecific clinical presentation, it poses considerable challenges for diagnosis and management. In this study, we describe the case of …

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Nuclear Lipin1 recruits HDAC2 to epigenetically repress SREBP1-dependent lipid synthesis and myelination in hypoxic preterm white matter injury

Xinyu Li, Xiaoyu Yao, Chunjie Guo, Yilin Liu et autres

Preterm white matter injury (PWMI) causes lasting neurological deficits by blocking oligodendrocyte precursor cell (OPC) differentiation. Perinatal hypoxia suppresses mechanistic target of rapamycin complex 1 (mTORC1), essential for OPC maturation. We identify Lipin1 nuclear translocation as a key downstream event of mTORC1 …

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Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu et autres

Cerebral palsy (CP), mainly resulting from preterm white matter injury (PWMI), remains a leading neurodevelopmental disorder. While oligodendrocyte precursor cell (OPC) differentiation failure is central to PWMI pathology, the metabolic mechanisms remain unclear. Here, untargeted lipidomic and metabolomic profiling of serum samples …

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Bta-miR-146b promotes infectious bovine rhinotracheitis virus replication and inhibits type I interferon expression via targeting IRAK1

Siping Zhu, Hong Li, Chihuan Li, Xintong Zhu et autres

Background: Infectious bovine rhinotracheitis virus (IBRV) is a primary pathogen causing bovine respiratory disease syndrome. This virus can cause rhinotracheitis and vaginitis in cattle, resulting in high mortality and posing a serious threat to bovine production. MicroRNAs (miRNAs), a class of regulatory …

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Circulating tumor DNA to guide rechallenge with cetuximab plus irinotecan in Chinese RAS/BRAF wild type metastatic colorectal cancer: A phase II trial.

Yu-hong Li, Wang De-shen, Wenchuan Chen, Chao Ren et autres

154 Background: Standard third-line therapies for metastatic colorectal cancer (mCRC) yield limited clinical benefit. Emerging evidence revealed that mutant RAS and EGFR extracellular domain variants detected in circulation during EGFR-targeted therapy exhibit diminished prevalence upon treatment cessation, correlating with restored therapeutic sensitivity. …

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Prognostic Significance of SOX9 and Its Combination With RAS and TP53 Mutations Following Colorectal Cancer Liver Metastasectomy

Jianli Duan, Lei Wen, Yanyu Cai, Kemin Jin et autres

Previous studies have highlighted the significance of genetic mutations in predicting the prognosis of patients undergoing resection for colorectal liver metastases (CRLM). Nonetheless, most studies were based on small-panel gene detection. The present study aimed to identify gene mutations associated with prognosis …

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Safeguarding the Characteristics of Zhuizi

Chao Ren, Awirut Thotham

This article analyzes the characteristics of Henan “Zhuizi,” a traditional vocal form native to Kaifeng, Henan, China, and part of the Chinese speaking and singing art known as “Quyi.” “Zhuizi” has experienced a significant decline since the 1980s, prompting urgent scholarly and …

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