Ling Zhou

Association of hyperuricemia with higher miscarriage rates and lower live birth rates in women undergoing IVF/ICSI

Ling Zhou, Jiahuan Luo, Shuhua Zhao, Longda Wang et autres

Hyperuricemia (HUA) has become popular globally, being an important risk factor for various metabolic diseases. Elevated serum uric acid (UA) levels cause adverse reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproductive technology (ART). However, its impact on reproductive outcomes …

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Altered Immune Cell Profiles in the Follicular Fluid of Patients with Poor Ovarian Response According to the POSEIDON Criteria

Ling Zhou, Jiahuan Luo, Meng Rao, Shuangjuan Yang et autres

Objective: This study aims to investigate alterations in immune cell counts within preovulatory follicles of patients with poor ovarian response (POR) during assisted reproductive technology (ART), classified according to the POSEIDON criteria. Methods: This single-centre cross-sectional study included 543 women undergoing IVF/ICSI …

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Evolutionary cues of gene fusion and fission in plants

Chuanjing An, Mengyuan Zhang, Yanru Song, Zhengwen Yan et autres

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Effect of oral probiotics on clinical efficacy and intestinal flora in elderly severe pneumonia patients

Yonglin Zhu, Guannan Ma, Wei Ren, Zhenyu Hu et autres

Complex microbial ecosystems in both gastrointestinal and respiratory systems have been found to have a significant impact on human health. Growing evidence has demonstrated that intestinal dysbiosis can increase vulnerability to pulmonary infections. However, changes in the composition and activity of the …

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Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor

Yinghui Wei, Meiling Zhang, Jing Tao Hu, Yingsi Zhou et autres

Approximately 140 million people worldwide are homozygous carriers of APOE4 (ε4), a strong genetic risk factor for late onset familial and sporadic Alzheimer's disease (AD), 91% of whom will develop AD at earlier age than heterozygous carriers and noncarriers. Susceptibility to AD …

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Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study

Zhexin Ni, Shanshan Mei, Siting You, Yi Lin et autres

Purpose: This work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET). Methods: Patients with/without PCOS who underwent FET from January 2013 and December 2018 were …

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Alpha‐linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis

Zhexin Ni, Jie Ding, Qianqian Zhao, Wen Cheng et autres

PROBLEM: This study aims to investigate the effects of alpha-linolenic acid (ALA) on the gut microbiota (GM) and the abdominal environment in mice with endometriosis (EMS). METHODS: The effects of faecal microbiota transplantation (FMT) from EMS mice on mice treated with antibiotic …

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Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis

Jing Shan, Zhexin Ni, Wen Cheng, Ling Zhou et autres

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Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Patients with Obesity Manifesting Polycystic Ovarian Syndrome

Zhexin Ni, Wen Cheng, Jie Ding, Ruipin Yao et autres

Gut microbiota disorders are closely related to polycystic ovarian syndrome (PCOS). Buzhong Yiqi prescription (BZYQ) has a significant clinical effect on the treatment of patients with obesity exhibiting PCOS and phlegm-dampness syndrome caused by spleen deficiency (SPSD). Hence, this study aimed to …

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Correlation Between Fecal Metabolomics and Gut Microbiota in Obesity and Polycystic Ovary Syndrome

Ling Zhou, Zhexin Ni, Jin Yu, Wen Cheng et autres

Objective: This study aimed to explore the relationship between the fecal metabolites and gut microbiota in obese patients with PCOS and provide a new strategy to elucidate the pathological mechanism of obesity and PCOS. Methods: The fecal samples of obese patients with …

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Correlation of fecal metabolomics and gut microbiota in mice with endometriosis

Zhexin Ni, Shuai Sun, Yanli Bi, Jie Ding et autres

PROBLEM: Endometriosis (EMS) is a chronic inflammatory disease with unclear pathogenesis. Three studies have uncovered the influence of gut microbiota on mice with EMS, but no study has investigated the characteristics of fecal metabolomics to determine some important clues on EMS. This …

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Characteristic gut microbiota and predicted metabolic functions in women with PCOS

Ling Zhou, Zhexin Ni, Wen Cheng, Jin Yu et autres

Polycystic ovary syndrome (PCOS) is a chronic endocrine and metabolic disease. Gut microbiota is closely related to many chronic diseases. In this study, we conducted a cross-sectional study and recruited 30 obese (OG) and 30 non-obese (NG) women with PCOS, 30 healthy …

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