Xiao Lu

Behavioral Activation for Depression and Glycemic Control in Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Xiao Lu, Tian Xia, Zhuo Wang, Mengjiao Cheng et autres

INTRODUCTION: Depression in type 2 diabetes mellitus (T2DM) hinders self-management and glycemic control. Behavioral activation (BA), by increasing participation in positive activities, holds promise for simultaneously improving depressive symptoms and diabetes outcomes. OBJECTIVE: This study evaluated the effects of BA or BA-based …

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Metabolic syndrome is associated with excessive scarring: A prospective cohort study from the UK Biobank

Zican Yang, Shizhen Xiang, Y Z Zhang, Enzhu Dong et autres

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Comparative evaluation of ChatGPT-5.0, DeepSeek-R1, and Gemini-2.5 pro in real-world outpatient prescription counseling: A multidimensional analysis

Quanyuan Huang, Wuchang Zhu, Huizhen Mo, Bingxiu Huang et autres

Objective: To compare the performance of ChatGPT-5.0, DeepSeek-R1, and Gemini-2.5 Pro in real-world outpatient prescription counseling and evaluate their applicability across clinical contexts. Methods: Fifty authentic prescriptions from four departments were submitted to the three models using standardized Chinese prompts. Responses were …

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Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule

Hong Zheng, Yanqi Li, Xiao Lu, Jiao Zhang et autres

Most persistent ground glass nodules (GGNs) are eventually diagnosed as early-stage lung adenocarcinoma (LUAD). Delving into the molecular underpinnings of malignant transformation of GGNs will aid in the development of preventive and therapeutic strategies to interrupt the occurrence and progression of early-stage …

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Knowledge mapping of Cushing syndrome: A bibliometric analysis from 2000 to 2023

Xiao Lu, Mingyu Huang, Yufang Yang, Dongxiao Chen et autres

BACKGROUND: Cushing syndrome (CS) is an endocrine disorder primarily caused by cortisol overproduction, resulting in a range of clinical manifestations. Although recent studies have advanced the understanding and treatment of CS, no comprehensive bibliometric analysis has yet mapped the development and trends …

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A Bibliometric Analysis of Research on Natural Medicines for Depression from 2004 to 2024

Linsun Lin, Ziyi Guo, Peigang Fang, Haojun Shi et autres

Objective: Depression imposes a severe global health burden. Natural medicines offer multi-target therapeutic potential, but a comprehensive bibliometric assessment of this field is lacking. This study analyzes the research landscape from 2004 to 2024 to map global contributions, collaboration networks, and evolving …

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A trans-kingdom T6SS RNase effector targeting both prokaryotic and host cells for pathogenesis

Y. Wang, Y. Li, Zonglan Yu, Wenjing Zhang et autres

The bacterial type VI secretion system (T6SS) mediates interactions with neighboring cells or the environment by secreting various effectors, yet T6SS RNase effectors have barely been studied. Here, we report a multifunctional trans-kingdom T6SS RNase effector, TseR, from Yersinia pseudotuberculosis (Yptb). TseR, …

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[Effectiveness and safety analysis of simultaneous bilateral total knee arthroplasty in treatment of patients aged 65 years and younger with bilateral knee osteoarthritis].

Jie Zhao, Qiang Wang, Weijie He, Huazheng He et autres

Objective: To investigate the effectiveness and safety of simultaneous bilateral total knee athroplasty (SB-TKA) for the treatment of patients aged 65 years and younger with bilateral knee osteoarthritis (KOA) by comparing with patients undergoing unilateral total knee arthroplasty (U-TKA). Methods: >0.05). The …

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HK2-mediated augmentation of endothelial cell glycolysis promotes placental vascular disorders through lactylation and pyroptosis

Xiujing Lu, Yu Long, Xiaoqian Fu, Min Wu et autres

Preeclampsia (PE) involves complex metabolic-inflammatory interactions, yet the mechanistic links among glycolysis, protein lactylation, and pyroptosis in placental pathogenesis remain undefined. This study explores their tripartite relationship with PE development by combining bioinformatics analysis of PE-associated transcriptomes with experimental validation using placental …

Hybrid deep learning enables multi-institutional delineation of active bone marrow for gynecologic radiotherapy

Zhe Zhang, Xiao Lu, Sicheng He, Shaobin Wang et autres

Background and purpose: F-FDG PET/CT as a reference, we developed a deep learning method to detect hematopoietic active bone marrow (ABM) on CT in gynecologic cancer patients and assess clinical benefits. Materials and methods: We analyzed 319 patients from five institutions retrospectively. …

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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

Ruifang Luo, Yuan Miao, Riqiang Hu, Lin Fang et autres

Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide (LPS) exposure during pregnancy is unclear. In this study, Tlr4 fl/fl and Tlr4 △IEC …

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Isoform switch of T-cell factor7L2 during mouse heart development

Bo Ye, Xiao Lu, Yuyong Xu, Haodong Xu et autres

Canonical WNT signaling plays critical, often opposing roles in heart development and disease, but its context-dependent mechanisms remain unclear. We hypothesized that alternative splicing of Tcf7l2, a key nuclear partner of β-catenin, contributes to WNT signaling specificity in the heart. To investigate …

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