Zhuoyu Li

Design principles of prosthetic reconstruction after pelvic tumor resection: a systematic review and perspective from modular systems to 3D-printed personalized solutions

Jiachen Yu, Zhiping Deng, Zhuoyu Li, Daoyang Fan et autres

Pelvic reconstruction after tumor resection remains one of the greatest challenges in orthopaedic oncology because of the pelvis’s complex anatomy, critical load-bearing function, and proximity to major neurovascular and visceral structures. Traditional reconstruction methods, including allografts and standardized modular prostheses, are limited …

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Identifying high-risk patient clusters for falls using unsupervised machine learning on linked primary and secondary care electronic health record data

Rachael Lear, Rachel Tao, Catalina Carenzo, Ekin YAGIS et autres

Falls risk is multifactorial, involving a combination of clinical and sociodemographic factors. Although guidelines acknowledge this complexity, most research has focused on individual risk factors, leaving the combined impact of comorbidities relatively understudied. This population-wide study used electronic health records (EHR) linked …

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Artificial Intelligence in the Diagnostic Imaging of Bone Tumours: A Systematic Review and Meta-Analysis

Zhuoyu Li, Daoyang Fan, Qing Zhang, Weifeng Liu

Background Primary bone tumours are rare, accounting for approximately 0.2% of all malignancies, with osteosarcoma, chondrosarcoma, and Ewing sarcoma representing the most common entities. Bone metastases occur in up to 70% of patients with advanced breast, prostate, and lung cancers, making them …

A retrospective study on the efficacy and safety of anlotinib combined with limb salvage therapy for osteosarcoma after chemotherapy failure

Sun Y, Daoyang Fan, Tao Jin, Zhuoyu Li et autres

This study aimed to evaluate the efficacy and safety of anlotinib combined with limb salvage therapy in patients with osteosarcoma after chemotherapy failure. A retrospective study was conducted on 46 eligible osteosarcoma patients who failed chemotherapy, admitted to our hospital from October …

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Is delayed three-month re-excision safe for patients who have undergone unplanned excision of soft tissue sarcomas?

Jin Tao, Zhuoyu Li, Li Yuan, H Xu et autres

BACKGROUND: The optimal timing for systematic re-excision following the unplanned excision (UE) of soft tissue sarcomas (STS) remains controversial. This study evaluated the impact of delayed versus immediate re-excision on overall survival (OS), progression-free survival (PFS), and local recurrence-free survival (LRFS). METHODS: …

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Therapeutic efficacy and safety of Xuebijing in traumatic brain injury: systematic review and meta-analysis

Yihan Sun, Jiaqi Li, Xinyue Cui, Miao Yu et autres

Background: Traumatic brain injury (TBI) represents a major global health challenge. Several clinical studies have suggested that Xuebijing (XBJ)-a patented Chinese botanical drug preparation may confer neuroprotective and anti-inflammatory benefits in TBI. This systematic review and meta-analysis aimed to evaluate the therapeutic …

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Prosthetic reconstruction or hip transposition after periacetabular tumour resection?

Zongyi Wang, Daoyang Fan, Jiakang Shen, Dongqing Zuo et autres

Aims: Reconstruction after periacetabular tumour resection poses significant challenges in limb salvage surgery, particularly in the management of its complications and in optimizing functional outcome. This study aims to compare the outcomes of prosthetic reconstruction and hip transposition, and to develop a …

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Application of a rapid and accurate safe-margin volume generation method in computer-assisted bone tumor resection surgery

Yu Zhang, Daming Pang, Zhuoyu Li, Yang Sun et autres

INTRODUCTION: In computer-assisted bone tumor resection, surgeons manually plan cut planes with a safe margin before surgery and follow them using navigation during osteotomy. However, manual planning is prone to error and often fails to ensure adequate margins. To address this, we …

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What Are the Long-term Outcomes of Wrist Arthrodesis Using Structural Iliac Bone Graft After Resection of the Distal Radius for Giant Cell Tumor of Bone? A Minimum 10-year Follow-up

Zhuoyu Li, Daoyang Fan, Zhiping Deng, Yongkun Yang et autres

BACKGROUND: Most distal radial giant cell tumors are treated with curettage, whereas malignancies and very advanced giant cell tumor of bone (GCTB) may be treated with resection. Wide resection can achieve good local control, but no consensus has been obtained on the …

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Is Ipsilateral Femoral Head Autograft Reconstruction Durable in Patients Undergoing Enneking II/II+III Tumor Resections at a Minimum 5-year Follow-up?

Zhuoyu Li, Daoyang Fan, Tao Jin, Yang Sun et autres

BACKGROUND: The reconstruction options for Enneking II/II+III pelvic tumors-defined as periacetabular tumor with or without involving the pubis or ischium-remain controversial. Short-term outcomes of ipsilateral femoral head autograft for the reconstruction of acetabular defects have been reported in limited case series studies. …

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Soft tissue reconstruction of tumor-related proximal tibial hemiarthroplasty using synthetic mesh combined with a medial gastrocnemius flap

Zhuoyu Li, Jing Zhao, Daoyang Fan, Zhiping Deng et autres

PURPOSE: This study was to evaluate the efficacy of soft tissue reconstruction using synthetic mesh and a medial gastrocnemius flap in patients who underwent proximal tibial hemiarthroplasty after resection of proximal tibial bone sarcomas. METHODS: A retrospective cohort study was conducted on …

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The clinical outcomes of joint-preserving endoprosthesis reconstruction for primary sarcomas about the knee

Zhuoyu Li, Weifeng Liu, Xiaohui Niu, Chunyan Jiang et autres

PURPOSE: The purpose of this study was to investigate the clinical outcomes of joint-preserving endoprosthesis reconstruction for primary sarcomas about the knee. METHODS: A retrospective cohort study was conducted on 45 patients (21 males, 24 females) who underwent joint-preserving endoprosthesis reconstruction (JPER) …

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