Yanqing Zhang

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors

Yemin Xu, Li Ding, Mengyue Wu, Xiya Wang et autres

BACKGROUND: Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy …

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Injectable hypoxia-preconditioned human exfoliated deciduous teeth stem cells encapsulated within GelMA-AMP microspheres for bone regeneration in periodontitis

Yu Chen, Bing Guo, Yanqing Zhang, Xinyu Bao et autres

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PAX4 gene delivery improves β-cell function in human islets of Type II diabetes

Yanqing Zhang, Keshab R. Parajuli, Vivian Fonseca, Hongju Wu

Aim: Type II diabetes (T2D) stems from insulin resistance, with β-cell dysfunction as a hallmark in its progression. Studies reveal that β cells undergo apoptosis or dedifferentiation during T2D development. The transcription factor PAX4 is vital for β differentiation and survival, thus …

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New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol

Fanhua Meng, Shuai Liu, Jian Xiao, Yüxia Zhou et autres

Background: Lower plasma levels of LDL (low-density lipoprotein) cholesterol (LDL-C) can reduce the risk of atherosclerotic cardiovascular disease. The loss-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) have been known to associate with low LDL-C in many human populations. PCSK9 genetic …

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Identification of ferroptosis‑associated genes in chronic kidney disease

Lishi Shao, Qixiang Fang, Chaofei Ba, Yanqing Zhang et autres

Ferroptosis serves a pivotal role in developing chronic kidney disease (CKD). The present study aimed to detect and confirm the relevance of potential ferroptosis-related genes in CKD using bioinformatics and experimentation strategies. The original GSE15072 mRNA expression dataset was retrieved from the …

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Intracrine testosterone activation in human pancreatic β cells stimulates insulin secretion.

Ada Admin, Weiwei Xu, Lina Schiffer, Mirza Muhammad Fahd Qadir et autres

Testosterone (T) affects β cell function in men and women. T is a pro-hormone that undergoes intracrine conversion in target tissues to the potent androgen dihydrotestosterone (DHT) via the enzyme 5α-reductase (5α-R), or to the active estrogen 17β-estradiol (E2) via the aromatase …

Intracrine testosterone activation in human pancreatic β cells stimulates insulin secretion.

Ada Admin, Weiwei Xu, Lina Schiffer, Mirza Muhammad Fahd Qadir et autres

Testosterone (T) affects β cell function in men and women. T is a pro-hormone that undergoes intracrine conversion in target tissues to the potent androgen dihydrotestosterone (DHT) via the enzyme 5α-reductase (5α-R), or to the active estrogen 17β-estradiol (E2) via the aromatase …

Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion

Weiwei Xu, Lina Schiffer, Mirza Muhammad Fahd Qadir, Yanqing Zhang et autres

Testosterone (T) affects β-cell function in men and women. T is a prohormone that undergoes intracrine conversion in target tissues to the potent androgen dihydrotestosterone (DHT) via the enzyme 5α-reductase (5α-R) or to the active estrogen 17β-estradiol (E2) via the aromatase enzyme. …

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The Blood Gene Expression Signature for Kawasaki Disease in Children Identified with Advanced Feature Selection Methods

Bing Hu, Yun Li, Guilian Wang, Yanqing Zhang

Kawasaki disease (KD) is an acute vasculitis, accompanied by coronary artery aneurysm, coronary artery dilatation, arrhythmia, and other serious cardiovascular diseases. So far, the etiology of KD is unclear; it is necessary to study the molecular mechanism and related factors of KD. …

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Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting β Cell Survival and α-to-β Cell Transdifferentiation

Keshab R. Parajuli, Yanqing Zhang, Alexander M. Cao Zhang, Hongjun Wang et autres

The transcription factor Pax4 plays an essential role in the development of insulin-producing β cells in pancreatic islets. Ectopic Pax4 expression not only promotes β cell survival but also induces α-to-β cell transdifferentiation. This dual functionality of Pax4 makes it an appealing …

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Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68:

Yanqing Zhang, Keshab R. Parajuli, Genevieve E. Fava, R. C. Gupta et autres

In the article cited above, nPOD funding information was mistakenly omitted. The following statement has been added to the Funding section to correct this: “This research was performed with the support of …

Medical Therapy Induced Regression of Plaque in a Female Patient with ASCVD

Siming Guan, Yanqing Zhang, Bin Wang, Wěi Li

The initiation and progression of atherosclerotic cardiovascular disease (ASCVD) has always been associated with a series of risk factors. Evidences of statin therapy from randomized clinical trials are abundant, whereas discussions regarding patients with ASCVD without evidence-based risk factors are rare. Here, …

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