Yuanyuan Huang

GO-HKP: A Gene Ontology hierarchy-driven framework for enzyme k cat prediction

Zhitao Mao, Hao Chen, Yuanyuan Huang, Hongwu Ma

GO-HKP is a Gene Ontology hierarchy-driven framework for predicting enzyme turnover numbers ( k cat ) with improved coverage, generalizability, and interpretability. It integrates curated UniProt data, ontology-based k cat propagation, and sequence-driven GO annotation (DeepGO-SE) to infer k cat for both …

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Stress-Inflammation Dysregulation and Biomarker Dynamics in Pediatric Mycoplasma Pneumoniae Pneumonia

Wen He, Chong‐Yu Xu, Yuanyuan Huang, Zeyu Yang et autres

Mycoplasma pneumoniae pneumonia (MPP) is a common pediatric infection frequently accompanied by systemic inflammation and psychological stress; however, its potential bidirectional relationship remains poorly defined. We retrospectively analyzed 120 hospitalized children aged 5-12 years using the Child Stress Questionnaire (CSQ), inflammatory mediators …

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GotEnzymes2: expanding coverage of enzyme kinetics and thermal properties

B Lyu, Ke Wu, Yuanyuan Huang, Mihail Anton et autres

Enzyme kinetics are fundamental for understanding metabolism, yet experimentally measured parameters remain scarce. To address this gap, we introduce GotEnzymes2, a substantially expanded resource covering 10 765 species, 7.3 million enzymes, and 59.6 million unique entries. Compared with the first version, GotEnzymes2 …

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A Peano-Gosper Fractal-Inspired Stretchable Electrode with Integrated Three-Directional Strain and Normal Pressure Sensing

Chunge Wang, Yuanyuan Huang, Zixia Zhao, Haoyu Li et autres

A novel stretchable flexible electrode capable of simultaneously detecting isotropic three-directional strain and normal pressure has been developed. Inspired by the recursive symmetry of the Peano-Gosper fractal, the electrode integrates liquid metal (EGaIn) microchannels within a PDMS matrix to achieve uniform strain …

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Pharmacokinetics, safety, and efficacy of mixed formulation of fosrolapitant and palonosetron (HR20013) in combination with dexamethasone in patients with solid tumors scheduled for highly emetogenic cisplatin-based chemotherapy: a phase I trial

Yuanyuan Zhao, Yu‐Xiang Ma, Tingyi Yin, Zhiquan Qin et autres

This phase I trial aimed to assess the pharmacokinetics (PK), safety, and preliminary efficacy of a single dose of HR20013 (mixed formulation of fosrolapitant and palonosetron) plus dexamethasone in patients with malignant solid tumors. Solid tumor patients who were naive to cisplatin-based …

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Bio-based PFA polymer: Achieving high toughness of polylactic acid (PLA) via copolymerization with poly(pentanediol furandicarboxylate)

Yonggang Lin, Ruimin Tang, Qiqi Yin, Xinyu Song et autres

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Global patterns and determinants of erosion-induced soil carbon translocation

Fangli Wei, Lanhui Wang, Lizhi Jia, Yuanyuan Huang

Soil erosion is a critical process influencing the global carbon cycle. However, erosion-induced carbon changes remain inadequately understood, particularly for soil inorganic carbon (SIC). There is also limited knowledge about the factors influencing soil carbon dynamics during erosion processes. Here we quantify …

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Revealing multiple biological subtypes of schizophrenia through a data-driven approach

Yuran Wang, Shixuan Feng, Yuanyuan Huang, Runlin Peng et autres

INTRODUCTION: The brain imaging subtypes of schizophrenia have been widely investigated using data-driven approaches. However, the heterogeneity of SZ in multiple biological data is largely unknown. METHODS: A data-driven model was used to classify brain imaging, gut microbiota, and brain-gut fusion data …

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Abstract 2864: DXA023-G017, a bispecific PD-1/VEGF conjugate elicits potent anti-tumor efficacy in preclinical studies

Xiaobo Cai, Weitao Zheng, Junxiang Jia, Sheng Hu et autres

Abstract Background: Programmed cell death protein 1 (PD-1) and vascular endothelial growth factor (VEGF) are often co-expressed in the tumor microenvironment. VEGF not only promotes tumor vessel normalization but also effectively alleviates immunosuppression, thereby enhancing the infiltration and activation of immune effector …

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Inorganic Carbon Should Be Considered for Carbon Sequestration in Agricultural Soils

Yang Liao, Lei Deng, Yuanyuan Huang, Jianzhao Wu et autres

ABSTRACT Improved agricultural practices that restore soil organic carbon (SOC) are recognized as climate solutions, whereas soil inorganic carbon (SIC) is ignored nearly in all practices. Here, we meta‐analyzed the joint response of SOC and SIC to six common agricultural practices, i.e., …

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The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy

Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia et autres

Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patient needs drive ongoing innovation in ADC development. Exploration of new small-molecule toxins with unique antitumor and toxicity profiles …

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Microneedles Constructed by Swellable Hydrogels Loaded with Celastrol for Efficient Treatment of Skin Infections Induced by Drug-Resistant Bacterial Strains

Jianbin Deng, Mengqi Liu, Shiqi Gao, Zhicheng Su et autres

The urgent need for new antimicrobial drugs arises from the limited efficacy of traditional antibiotics against emerging drug-resistant strains. Celastrol (CSL) demonstrates an exceptional antibacterial property that remains unaffected by bacterial resistance, but its poor water solubility limits its wide applications. This …

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