Pan Shi

Rational design of a kappa opioid receptor (KOR) peptide agonist with attenuated β-arrestin signaling

Huanhuan Zhang, Ruolan Wang, Pan Shi, Xinheng He et autres

The Cryo-EM map of difelikefalin–KOR–Gi complex The PDB of difelikefalin–KOR–Gi complex The Cryo-EM map of beta01–KOR–Gi complex The PDB of beta01–KOR–Gi complex

Rational design of a kappa opioid receptor (KOR) peptide agonist with attenuated β-arrestin signaling

Huanhuan Zhang, Ruolan Wang, Pan Shi, Xinheng He et autres

The Cryo-EM map of difelikefalin–KOR–Gi complex The PDB of difelikefalin–KOR–Gi complex The Cryo-EM map of beta01–KOR–Gi complex The PDB of beta01–KOR–Gi complex

Non-Local and Non-Markovian Effects of a Microscopic Two-Level Defect in Superconducting Quantum Circuits

Yang Gao, Yujia Zhang, Huikai Xu, Pan Shi et autres

Microscopic two-level systems (TLS) -- ubiquitous atomic-scale defects in solid-state quantum devices -- are a dominant source of qubit decoherence, yet their role is often considered local and short-memoried. Here, we report the observation of a coherent TLS that couples simultaneously to …

Non-Local and Non-Markovian Effects of a Microscopic Two-Level Defect in Superconducting Quantum Circuits

Yang Gao, Yujia Zhang, Huikai Xu, Pan Shi et autres

Microscopic two-level systems (TLS) -- ubiquitous atomic-scale defects in solid-state quantum devices -- are a dominant source of qubit decoherence, yet their role is often considered local and short-memoried. Here, we report the observation of a coherent TLS that couples simultaneously to …

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Additional file 1 of 9.4-T MRI monitoring of early MASH progression and therapeutic response in a prefibrotic mouse model

Yuanyuan Li, Y N Wu, Gengxin Wang, Yanmin Zheng et autres

Additional file 1: Figure S1. Representative histological images of sectioned liver tissues in NFD group stained with H&E and Oil red O during modeling. Scale bar, 50 μm. HFHCD, high-fat high-cholesterol diet; H&E, hematoxylin-eosin; NFD, normal-fat diet. Figure S2. Representative histological images …

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9.4-T MRI monitoring of early MASH progression and therapeutic response in a prefibrotic mouse model

Yuanyuan Li, Y N Wu, Gengxin Wang, Yanmin Zheng et autres

Abstract Objective Early intervention in metabolic dysfunction-associated steatohepatitis (MASH) is critical to halt disease progression. However, noninvasive tools for monitoring early-stage MASH and therapeutic efficacy in preclinical models remain limited, impeding preclinical drug development. This study establishes an integrated approach using multiparametric …

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Additional file 1 of 9.4-T MRI monitoring of early MASH progression and therapeutic response in a prefibrotic mouse model

Yuanyuan Li, Y N Wu, Gengxin Wang, Yanmin Zheng et autres

Additional file 1: Figure S1. Representative histological images of sectioned liver tissues in NFD group stained with H&E and Oil red O during modeling. Scale bar, 50 μm. HFHCD, high-fat high-cholesterol diet; H&E, hematoxylin-eosin; NFD, normal-fat diet. Figure S2. Representative histological images …

cn (code pays fourni par la source)

9.4-T MRI monitoring of early MASH progression and therapeutic response in a prefibrotic mouse model

Yuanyuan Li, Y N Wu, Gengxin Wang, Yanmin Zheng et autres

Abstract Objective Early intervention in metabolic dysfunction-associated steatohepatitis (MASH) is critical to halt disease progression. However, noninvasive tools for monitoring early-stage MASH and therapeutic efficacy in preclinical models remain limited, impeding preclinical drug development. This study establishes an integrated approach using multiparametric …

cn (code pays fourni par la source)

Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis

Shasha Zhang, Xinran Li, Yaxin Gao, Qian Dong et autres

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Nicotinamide N-oxide alleviates sepsis-induced hepatic inflammation, oxidative stress, and mitochondrial damage depends on SIRT3/AKT signaling pathway

Shujuan Liu, Pan Shi, Yichen Jin, Liwen Fan et autres

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Fault section location method for distribution network based on distributed sensing and random forest

Pan Shi, Jipu Gao, Xiaozhou Jiang, Yuanyuan Zhang et autres

To address the challenges of weak electrical characteristics, complex fault types, and transient diversity caused by grid-connected distributed power sources in low-current grounded distribution networks, a method for locating distribution network fault sections based on distributed sensing and random forests was proposed. …

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Distribution network fault identification based on AdaBoost combined with KNN algorithm

Xiaozhou Jiang, Jipu Gao, Pan Shi, Yuanyuan Zhang et autres

This paper addresses the challenge of fault type identification in distribution networks, where small-current grounding systems often lead to weak fault current characteristics and limit the performance of traditional methods. To overcome issues of low feature discriminability, poor noise immunity, and weak …

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