Yumin Zheng

ATAD2 is a novel regulator of myogenesis and autophagy in skeletal muscles

Sami Sedraoui, Alaa Moamer, Tomer Jordi Chaffer, Jean‐Philippe Leduc‐Gaudet et autres

Abstract The nuclear protein ATAD2 (ATPase family AAA domain containing 2) is a known positive regulator of cell proliferation in various cancer types. The expression and functional roles of ATAD2 in skeletal muscle cells are unknown. In this study, we used transient …

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GeneRhythm uncovers gene expression rhythms that shape the dynamic transcriptional landscape in single-cell omics

Jun Ding, Xiuhui Yang, Yiming Jia, Braeden Giles et autres

ca, ae, cn (code pays fourni par la source)

SIDISH integrates single-cell and bulk transcriptomics to identify high-risk cells and guide precision therapeutics through in silico perturbation

Yasmin Jolasun, Kailu Song, Yumin Zheng, Jingtao Wang et autres

Single-cell RNA sequencing (scRNA-seq) provides high-resolution insights into cellular heterogeneity but remains costly, restricting its use to small cohorts that often lack comprehensive clinical data, reducing translational relevance. In contrast, bulk RNA sequencing is scalable and cost-effective but obscures critical single-cell insights. …

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DOLPHIN advances single-cell transcriptomics beyond gene level by leveraging exon and junction reads

Kailu Song, Yumin Zheng, Bowen Zhao, David H. Eidelman et autres

The advent of single-cell sequencing has revolutionized the study of cellular dynamics, providing unprecedented resolution into the molecular states and heterogeneity of individual cells. However, the rich potential of exon-level information and junction reads within single cells remains underutilized. Conventional gene-count methods …

ca (code pays fourni par la source)

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases

Yumin Zheng, Jonas C. Schupp, Taylor Adams, Gérémy Clair et autres

Human diseases are characterized by intricate cellular dynamics. Single-cell transcriptomics provides critical insights, yet a persistent gap remains in computational tools for detailed disease progression analysis and targeted in silico drug interventions. Here we introduce UNAGI, a deep generative neural network tailored …

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SIDISH Identifies High-Risk Disease-Associated Cells and Biomarkers by Integrating Single-Cell Depth and Bulk Breadth

Yasmin Jolasun, Yumin Zheng, Kailu Song, David H. Eidelman et autres

ca (code pays fourni par la source)

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection

Salyan Bhattarai, Eva Kaufmann, Feng‐Xia Liang, Yumin Zheng et autres

BACKGROUND: COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue, particularly …

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MATES: a deep learning-based model for locus-specific quantification of transposable elements in single cell

Ruohan Wang, Yumin Zheng, Zijian Zhang, Kailu Song et autres

Transposable elements (TEs) are crucial for genetic diversity and gene regulation. Current single-cell quantification methods often align multi-mapping reads to either ‘best-mapped’ or ‘random-mapped’ locations and categorize them at the subfamily levels, overlooking the biological necessity for accurate, locus-specific TE quantification. Moreover, …

ca, us (code pays fourni par la source)

Unagi: Deep Generative Model for Deciphering Cellular Dynamics and In-Silico Drug Discovery in Complex Diseases

Yumin Zheng, Jonas C. Schupp, Taylor Adams, Gérémy Clair et autres

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転座蛋白と神経系変性疾患【JST・京大機械翻訳】

Liu Na, Yumin Zheng, Luo Xiaoguang, Ren Yan

Actuality Analysis of Condition-Based Maintenance Technology for Hydroelectric Generating Unit

Yumin Zheng, Qijuan Chen, Qunli Li, Youping Li

Based on the surveying of condition based maintenance technology organized by China Three Gorges Project Company, the condition-based maintenance system for hydroelectric generating unit and its application environment are discussed in this paper. Its function, structure characters and research hotspots are summarized …

cn (code pays fourni par la source)