Shuk Han Cheng

Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients With Infective Endocarditis: A Target Trial Emulation

Teddy Tai Loy Lee, Chengsheng Ju, Sunny Ching Long Chan, Oscar Hou In Chou et autres

BACKGROUND: Infective endocarditis (IE) can be complicated by acute heart failure and bacteremia, which can account for increased mortality. The role of anticoagulation with warfarin in IE is controversial. This study aimed to study the effects of anticoagulation with warfarin on survival …

pl, hk, gb, cn, bd (code pays fourni par la source)

Deep learning enhanced deciphering of brain activity maps for discovery of therapeutics for brain disorders

Xianrui Zhang, Zhen Liu, Xuan Luo, Yi Lin Cao et autres

phenotypic screening for generating the BAM library. Deep learning is applied to deconvolve the pharmacological information from the BAM library and to predict the therapeutical potential of non-clinical compounds without any prior information about the chemicals. For a validation set composed of …

hk, cn, us (code pays fourni par la source)

Genetic associations between SGLT2 inhibition, DPP4 inhibition or GLP1R agonism and prostate cancer risk: a two-sample mendelian randomisation study

Lin Shen, Yifan Yang, Lei Lü, Oscar Hou In Chou et autres

Radiation-induced rescue effect on human breast carcinoma cells is regulated by macrophages

Spoorthy Pathikonda, Li Tian, Clement Manohar Arava, Shuk Han Cheng et autres

The susceptibility of cancer cells to DNA damages is influenced by their microenvironment. For example, unirradiated neighbors of irradiated cells can produce signals that reduce DNA damages. This phenomenon, known as Radiation-Induced Rescue Effect (RIRE), has profound implications on the efficacy of …

hk, fr, gb (code pays fourni par la source)

Pathological Response and Survival Outcome after Neoadjuvant Chemoradiotherapy vs. Immunochemotherapy for Patients with Locally Advanced Esophageal Squamous Cell Carcinoma

Shuk Han Cheng, Yu‐Hsueh Wu, WU Jianing, Qun Zhao et autres

cn (code pays fourni par la source)

Genetic associations between SGLT2 inhibition, DPP4 inhibition or GLP1R agonism and prostate cancer risk: a two-sample Mendelian randomisation study

Lin Shen, Yifan Yang, Lei Lü, Oscar Hou In Chou et autres

Abstract Background Epidemiological studies have linked the use of the anti-diabetic medications, sodium-glucose co-transporter-2 inhibitors (SGLT2I), dipeptidyl peptidase-4 inhibitors (DPP4I) and glucagon-like peptide-1 receptor agonists (GLP1RA), with prostate cancer risk. However, these studies cannot infer causality. Methods This was a two-sample Mendelian …

cn, gb, hk (code pays fourni par la source)

Few-shot meta-learning applied to whole brain activity maps improves systems neuropharmacology and drug discovery

Xuan Luo, Yanyun Ding, Yi Heng Cao, Zhen Liu et autres

In this study, we present an approach to neuropharmacological research by integrating few-shot meta-learning algorithms with brain activity mapping (BAMing) to enhance the discovery of central nervous system (CNS) therapeutics. By utilizing patterns from previously validated CNS drugs, our approach facilitates the …

hk, cn, us (code pays fourni par la source)

Scalable Neuroanatomical and Behavioral Phenotyping of Radio Frequency Radiation on Young Zebrafish

Xiaoli Wu, Yu Suen Chan, Bing Jie Xiang, Kwai‐Man Luk et autres

Objective: In our wireless-centric world, evaluating the health effects of radio frequency electromagnetic radiation (RF-EMR) is crucial. An existing research gap pertains to the replication of real-world specific absorption rates (SAR) for RF-EMR, especially within aquatic environments. We aimed to bridge this …

hk, us (code pays fourni par la source)

Vertebrates on a Chip: Noninvasive Electrical and Optical Mapping of Whole Brain Activity Associated with Pharmacological Treatments

Zhen Liu, Xuan Luo, Richard Yan‐Do, Yuan Wang et autres

Mapping brain activities is necessary for understanding brain physiology and discovering new treatments for neurological disorders. Such efforts have greatly benefited from the advancement in technologies for analyzing neural activity with improving temporal or spatial resolution. Here, we constructed a multielectrode array …

hk, cn (code pays fourni par la source)

Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy

Fengyan Chen, Shiming Pu, Li Tian, Huan Zhang et autres

HEADINGS ETHNOPHARMACOLOGICAL RELEVANCE: Rehmanniae Radix Praeparata (RRP), a staple in traditional Chinese medicine, is derived from Rehmannia glutinosa Libosch and is renowned for its wound-healing properties. Despite its clinical prevalence, the molecular mechanisms underlying RRP's wound-healing effects have not been fully elucidated. …

cn, hk (code pays fourni par la source)

A High-Throughput Microdroplet-Based Single Cell Transfection Method for Gene Knockout Based on the CRISPR/Cas9 System

Jiayu Sun, Yang Jiao, Fei Pan, Shuk Han Cheng et autres

The efficient application of the newly developed gene-editing method CRISPR/Cas9 requires more accurate intracellular gene delivery. Traditional delivery approaches, such as lipotransfection and non-viral delivery methods, must contend with major problems to overcome the drawbacks of low efficiency, high toxicity, and cell-type …

hk (code pays fourni par la source)

Effects of Warfarin on the Risks of Mortality, Acute Heart Failure, and Infection Resolution in Patients with Infective Endocarditis: A Target Trial Emulation

Teddy Tai Loy Lee, Chengsheng Ju, Sunny C. L. Chan, Oscar Hou In Chou et autres

hk, gb, cn (code pays fourni par la source)