Yixin Li

Discovery of Pyrazole-Containing RGD Mimics with Anti-Fibrotic Efficacy in the Unilateral Ureteral Obstruction Mouse Model

Guohua Zhao, James John Mignone, Leatte Guernon, Eric Mull et autres

Fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), metabolic dysfunction-associated steatohepatitis (MASH), and kidney fibrosis represent a major unmet medical need. IPF patients have a mean survival of only 2-5 years, and despite this critical need, only two drugs have been approved …

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Morphology, transcriptome and physiology analyses reveal adaptation mechanisms of Gymnocypris Przewalskii juveniles to saline-alkaline stresses

Zihan Gao, Le Wang, Yanrong Cui, Yixin Li et autres

BACKGROUND: Naked carp (Gymnocypris przewalskii), a fish endemic to Qinghai Lake, China, has attracted extensive attention for its adaptation to salinity and alkalinity stress. However, the survival mechanism of G. przewalskii against saline-alkaline water environments remains elusive. In this study, we aimed …

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Defect detection of the ceramics in thermal barrier coatings using bridge capacitive sensor

Guolong Chen, Xiaohong Luo, Pengcheng Zhang, Yu Han et autres

Thermal barrier coatings (TBCs) constitute an essential protective system for aeroengine turbine blades. However, their structural integrity faces significant challenges from thermo-mechanical-chemical effects during operational service. Under severe conditions, these effects accelerate the degradation of TBCs, eventually leading to failures including turbine …

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Efficacy and safety of first-line treatments for metastatic castration-resistant prostate cancer based on phase II and III randomized controlled trials: A PROSTA-MAP systematic review and network meta-analysis

Xuanjun Guo, Yixin Li, Mengying Wang, Hexiang Peng et autres

BACKGROUND: The landscape of metastatic castration-resistant prostate cancer (mCRPC) treatment has evolved greatly; however, limited data are available regarding its relative efficacy and safety. We conducted a systematic review and network meta-analysis to analyze and compare the effectiveness and safety of first-line …

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Ultrasound-based machine learning model to predict the risk of endometrial cancer among postmenopausal women

Yixin Li, Yu Lu, Yu-Ting Shen, Wen Lu et autres

BACKGROUND: Current ultrasound-based screening for endometrial cancer (EC) primarily relies on endometrial thickness (ET) and morphological evaluation, which suffer from low specificity and high interobserver variability. This study aimed to develop and validate an artificial intelligence (AI)-driven diagnostic model to improve diagnostic …

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MiR-383-5p promotes schistosomiasis-induced liver fibrosis by targeting peroxiredoxin-3

Yixin Li, Xinyue Zhang, Ju-Lu Lu, Yingying Yang et autres

BACKGROUND: Schistosomiasis-induced liver fibrosis, a major complication of infection, arises primarily from the host immune response to schistosome eggs. The mechanisms underlying the development of liver fibrosis remain unclear, but microRNAs (miRNAs) are thought to play a crucial role in this process. …

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Targeting YAP-Hhip-mediated osteogenesis in Gli1+ osteogenic progenitors suppresses aberrant subchondral bone remodeling in osteoarthritis

Yang Xiao, Shi‐Yang Feng, Shuo Chen, Yixin Li et autres

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Corrigendum: Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis

Wei Ren, Hanyu Zhang, Yixin Li, Wu Sun et autres

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Efficacy and safety of PD-1/PD-L1 inhibitors as first-line treatment for esophageal squamous cell carcinoma: a systematic review and meta-analysis

Wei Ren, Hanyu Zhang, Yixin Li, Wu Sun et autres

Purpose This study aims to investigate the efficacy and safety of PD-1/PD-L1 inhibitors in the first-line treatment of esophageal squamous cell carcinoma (ESCC) and identify factors influencing efficacy through a meta-analysis of multiple phase 3 randomized controlled trials (RCTs). Methods A systematic …

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Akt2 inhibition alleviates temporomandibular joint osteoarthritis by preventing subchondral bone loss

Shi‐Yang Feng, Chenchen Gao, Yixin Li, Jie Lei et autres

BACKGROUND: This study aimed to investigate the role and mechanism of the Akt2 pathway in different stages of anterior disc displacement (ADD)-induced temporomandibular joint osteoarthritis (TMJOA). METHODS: transducing units/mL 10 days before the ADD or sham operations. The rats were euthanized and …

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Morphology, Transcriptome and Physiology Analyses Reveal Adaptation Mechanisms of Gymnocypris Przewalskii Juveniles to Saline-Alkaline Stresses

Zihan Gao, Le Wang, Yanrong Cui, Yixin Li et autres

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Combined systemic immune-inflammatory index and prognostic nutritional index predicts the efficacy and prognosis of ES-SCLC patients receiving PD-L1 inhibitors combined with first-line chemotherapy

Yi Ge, Xiaoyu Liu, Yishi Xu, Yanwei Su et autres

Background: There is a strong association between inflammation and the formation, progression, and metastasis of malignant tumors, according to earlier studies. Some composite inflammation-nutritional indicators, such as the systemic immune-inflammation index (SII) and the prognostic nutritional index (PNI), have a certain predictive …

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