Yang An

PTEN-Long-mediated molecular therapy: current evidences and future perspectives

Tiantian Sun, Han Xu, Yurun Wang, Yi Ren et autres

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The CRISPR/Cas technology landscape: From molecular mechanisms to multidisciplinary applications

Zhenzhen Liu, Yutian Yang, Zhihao Li, Pengkun Li et autres

Genome editing technology, as one of the most revolutionary biotechnologies of the 21st century, has undergone rapid global advancement and profoundly influenced the development of diverse fields, including medicine. In particular, the clustered regularly interspaced short palindromic repeats-associated protein (CRISPR/Cas) system has …

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Emerging therapeutic significance of MEF2C : Structure, function and its implications in diseases

Jiawei Zhang, Yueyue Xie, Shuo Jiang, Shuo Huang et autres

Myocyte enhancer factor 2C (MEF2C) is a critical transcription factor and plays a pivotal role in muscle development, cardiac reprogramming, cellular differentiation, and disease pathogenesis. In this review, we have systematically described the structural characteristics of the MEF2C protein, particularly its DNA-binding …

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Seminal plasma extracellular vesicle–derived miR-296–3p targets PLA2G6 to enhance boar sperm motility by lowering Lys Phosphatidylcholine

Kun Zhao, Yang An, Yuyang Zhang, Junzheng Zhang et autres

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Exosomal lncRNA ENSSSCG00000049656 regulates porcine oocyte maturation via the ssc-miR-500-3p/EGLN2 axis

Junzheng Zhang, Yuyang Zhang, Hao Li, Jie Wang et autres

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Research on Integration Technology of Air Condition Refrigeration and Bleed Air Heating for Aircraft

Yang An, Yanpeng Ma, Shi-yi Song, Xiao-feng Lyu et autres

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Regulation of autophagy–Ferroptosis crosstalk by the SLC7A11–GPX4 axis during sperm capacitation

Zhiwei Yao, Jie Wang, Yuyang Zhang, Junzheng Zhang et autres

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How do infrared and near-infrared lasers influence autophagy and alveolar bone remodeling in rats during orthodontic tooth retention?

Yang An, Wen‐Jun Shen, An Li, Zhenqiang Li et autres

BACKGROUND: Few studies have explored the association between autophagy and osteogenesis during orthodontic retention. This study compared the impact of 660-nm infrared (IR) and 808-nm near-infrared (NIR) lasers on the autophagy and alveolar bone remodeling in rats during orthodontic tooth retention. METHODS: …

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Development of a cancer metastasis-associated risk model via multi-machine-learning algorithms for prognostic risk evaluation and clinical application in oral squamous cell carcinoma

Xu Han, Tiantian Sun, Yuanyuan Dai, Ruohan Yun et autres

BACKGROUND: Oral squamous cell carcinoma (OSCC) represents a highly malignant form of cancer characterized by molecular heterogeneity and unsatisfactory treatment outcomes, with approximately 50% of patients experiencing local recurrence and distant metastasis following therapy. Given that metastasis is the most critical determinant …

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Construction and validation of a disulfidptosis-related risk assessment model for prediction of prognosis, immune microenvironment, drug therapy, and microbiota in patients with low-grade glioma

Jiayang Han, Binbin Zhao, Man Yue, Mengwen Hou et autres

BACKGROUND: Disulfidptosis has been recently identified as a mode of programmed cell death, which is becoming a promising target for tumor treatment. However, its biological mechanism in low-grade glioma (LGG) has not yet been thoroughly investigated. Due to the molecular heterogeneity of …

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Deciphering influence and therapeutic significance of gut microbiota and its metabolites on metabolic diseases and inflammatory bowel disease

Xiumei Guo, Ying Zhao, Yanbing Pan, Pengkun Li et autres

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Rheb ubiquitination drives LC3 lipidation via non-canonical autophagy to promote porcine sperm acrosome reaction

Jie Wang, Zhiwei Yao, Yuyang Zhang, Junzheng Zhang et autres

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