Yaping Wang

Clinicopathological characteristics and prognosis analysis of gastrinoma based on the SEER database

Chengru Hu, Chengjie Lu, Zhenguo Qiao, Yaping Wang et autres

Gastrinoma, distinguished by Zollinger-Ellison Syndrome, is a highly unusual neoplasm. However, understanding of its clinicopathological characteristics and survival at the population level is inadequate. This study aimed to examine the clinicopathological features and survival of gastrinoma patients utilizing the Surveillance, Epidemiology, and …

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Microglial TREM2 deficiency causes E/I imbalance and triggers ASD-like behaviors by altering potassium channel Kv1.3 activation

Yaping Wang, Qiushi Wang, Rongfang Li, Youxin Yu et autres

Autism Spectrum Disorder (ASD) is a type of neurodevelopmental disorder characterized by deficits in social interaction and stereotyped behavior, with synaptic dysfunction playing a causal role in its pathogenesis. Microglia, as innate immune cells in CNS, are involved in regulation of synaptic …

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Reprogramming activated astrocytes into GABAergic neurons to treat trigeminal neuralgia

Kai Chen, Xin Li, Dingquan Zou, Meng Wang et autres

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Tannic Acid–Iron Complex-Based Nanozyme Ameliorates Parkinson’s Disease via Relieving Oxidative Stress and Neuroinflammation

Wenya He, Mengyao Liu, Tongyu Zhang, Yajing Sun et autres

Oxidative stress (OS)-induced neuronal damage and neuroinflammation form a vicious cycle that promotes the progression of Parkinson’s disease (PD). Herein, a therapeutic strategy exploiting the tannic acid (TA)–iron (Fe) complex-based nanoparticles (BSA/Fe-TA NPs) that simultaneously relieves brain OS and neuroinflammation is developed …

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DMH1-loaded peptide nanomicelles restore myelin and attenuate neuroinflammation in trigeminal neuralgia via CCL5 suppression

Xiunan Qin, Yaping Wang

Background Trigeminal neuralgia (TN), a debilitating neuropathic pain disorder, is characterized by demyelination and neuroinflammation, with limited therapies addressing its underlying pathophysiology. Bone Morphogenetic Protein 4 (BMP4) signaling and chemokine CCL5 are implicated in neuroinflammation and oligodendrocyte dysfunction, presenting potential therapeutic targets. …

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[Effect of morphine pump in prepontine cistern via lumbar approach for intractable head and neck cancer pain].

Wenjie Zhang, Xinning Li, Jiaxin Lei, Yanying Xiao et autres

OBJECTIVES: Managing patients with refractory head and neck cancer pain is one of the more challenging issues in clinical practice, and traditional intrathecal drug delivery also fails to provide adequate analgesia. There are currently no comprehensive and effective treatment methods. This study …

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Depression exacerbates AD pathology through lactate-dependent activation of microglial Kv1.3 to promote Aβ-containing exosome spreading

Xiaoli Liu, Huijun Wang, Xi Tian, Yingqi Luo et autres

Depression has been widely recognized as an important accelerating factor contributing to the aggravation of cognitive decline in Alzheimer's disease (AD) patients. Previous studies show that microglia-mediated neuroinflammation is a common and critical event in the etiology of both depression and dementia, …

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Understanding Cd Nano-Whisker Growth on Ti2CdC MAX Phase from the Perspective of Atomized Cd Migration

Xuelian Wu, Yaping Wang, Xinxin Xia, Jianxiang Ding et autres

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Comparison of Remimazolam and Propofol for Intravenous Anesthesia on Trigeminocardiac Reflex in Percutaneous Balloon Compression for Trigeminal Neuralgia: A Randomized Controlled Trial

Kai Chen, Yuan-Wen Li, Peiyao He, XinNing Li et autres

Background: Trigeminal neuralgia usually presents as incapacitating facial pain. Percutaneous balloon compression (PBC) is frequently utilized to manage this ailment. Trigeminocardiac reflex (TCR) commonly presents with sudden severe bradycardia or even asystole, alongside a sudden increase in blood pressure during this surgical …

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Efficacy Analysis of Temporary Spinal Cord Stimulation in the Treatment of Refractory Postherpetic Neuralgia

Xin Ying Li, Yaping Wang, Kai Chen, Dingquan Zou

BACKGROUND: Spinal cord stimulation can be considered in PHN patients if conservative treatment is not effective. However, the long-term pain outcomes of temporary (7-14 days) spinal cord stimulation (tSCS) in refractory PHN patients with a course of more than 3 months have …

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Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte

Kai Chen, Xiaojin Wei, Wenjuan Zhang, Ruixuan Wang et autres

INTRODUCTION: During postherpetic neuralgia (PHN), the cerebral spinal fluid (CSF) possesses the capability to trigger glial activation and inflammation, yet the specific changes in its composition remain unclear. Recent findings from our research indicate elevations of central bone morphogenetic protein 4 (BMP4) …

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Technical guideline for intra-prepontine cisternal drug delivery via spinal puncture through subarachnoid catheterization.

Xinning Li, Yaping Wang, Dingquan Zou, Wei Zhang et autres

OBJECTIVES: The distribution characteristics of intrathecal drugs and the limitation of current catheterization techniques make traditional intrathecal analgesic treatment nearly useless for refractory craniofacial pain, such as trigemina neuralgia. This technical guideline aims to promote the widespread and standardize the application of …

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