Han Wang

Smoking status and nonlinear associations of cerebrospinal fluid GDF11 and IGF2 with Subjective sleep quality: a cross-sectional study using generalized additive models

Xiaoyu Yang, Lidong Su, Tiantian Kong, Ruyue Li et autres

Cigarette smoking is consistently associated with poorer sleep, yet the central biochemical correlates of this relationship remain insufficiently characterized in humans. Growth differentiation factor 11 (GDF11) and insulin-like growth factor 2 (IGF2) are candidate biomarkers of vascular and neurotrophic signaling, but their …

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Experience with Hand-Sewn, Layered Telescoping Anastomosis in Oesophageal Cancer Surgery

Genrong Yang, Han Wang

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Recent advances in research on high-frequency mutations in the ATP7B gene associated with Wilson disease in the Chinese population: from genetic evolution to precision medicine

Qiaoyu Xuan, Daiping Hua, Lanting Sun, Qiyan Ma et autres

Wilson disease (WD) is a hereditary disorder of copper metabolism caused by mutations in the ATP7B gene; the Chinese population exhibits a unique, high-frequency mutation profile centered on the R778L and P992L mutations. This article provides a narrative review of the genetic …

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Case Report: Diagnosis and management of severe pneumonia caused by complex mixed infection with multidrug-resistant bacteria and fungi after liver retransplantation

Jiaying Lu, Yingying Xia, Han Wang, Chen Gao et autres

Background Patients undergoing liver retransplantation remain in a prolonged immunosuppressed state and are at high risk for complex mixed infections caused by multidrug-resistant organisms (MDROs) and invasive fungi. Under such circumstances, accurately identifying the predominant pathogens and developing a treatment strategy that …

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l -Arginine combined with 5-fluorouracil inhibits EMT by regulating iNOS expression in hepatocellular carcinoma

Han Wang, Yao Lu, Yiying Li, Qingzan Zhao et autres

This study investigated the synergistic effect of l-arginine [inducible nitric oxide synthase (iNOS) substrate] combined with 5-fluorouracil (5-FU, iNOS inducer) on epithelial–mesenchymal transition (EMT) in hepatocellular carcinoma (HCC).In vitro, the combination significantly inhibited HCC cell proliferation, invasion, migration, and upregulated iNOS. It …

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Systematic study and 30-year projections of global and multi-regional burden of multiple sclerosis, 1990–2021

Jie Liu, Han Wang, Yan Xu, Yuchen Guo et autres

Multiple sclerosis (MS) is a chronic neurodegenerative disease with significant temporal and regional heterogeneity. While earlier studies described the burden before 2019, recent shifts influenced by socioeconomic development, healthcare access, and environmental exposures remain unclear. Using the Global Burden of Disease database, …

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Preliminary Experience with Organ-Preserving Treatment for Locally Advanced Esophageal Cancer in the Immunotherapy Era: A Case Series of Three Patients

Han Wang

Preliminary Experience with Organ-Preserving Treatment for Locally Advanced Esophageal Cancer in the Immunotherapy Era: A Case Series of Three PatientsGenrong Yang；Han Wang(Department of Thoracic Surgery, The First Affiliated Hospital of Henan Univers

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Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang

ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel …

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Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma

Liang Chu, Han Wang, Tao Ling, Shuhan Feng et autres

Background The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC). Methods A multicenter retrospective cohort analysis was conducted involving 677 …

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IL-36-related genes predict prognosis of gastric cancer

Ying Zhang, Yanbo Liu, Xin Guan, Meng Qu et autres

Introduction: Gastric cancer (GC) is one of the most frequently encountered malignant tumors in the clinic. Because effective early screening techniques are lacking, most patients have advanced disease at first diagnosis. The interleukin (IL)-36 family plays a vital role in regulating the …

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Abstract PS3-01: Tislelizumab plus sitravatinib and nab-paclitaxel in patients with untreated locally recurrent or metastatic triple negative breast cancer (TNBC): updated efficacy and safety results

Xiyu Liu, Ying Xu, Xiuzhi Zhu, Wenjuan Zhang et autres

Abstract Background: The PD-(L)1 inhibitor-chemotherapy combination has established efficacy as first-line treatment for PD-L1 positive metastatic TNBC, but novel treatment regimens are still needed to improve the clinical outcomes for the whole population of TNBC in the first-line setting. Emerging evidence indicates …

Production and Characterization of Poly-γ-Glutamic Acid by Bacillus velezensis SDU

Han Wang, Haiping Ni, Shouying Xu, Cuiying Zhang et autres

In this study, a Bacillus velezensis SDU strain capable of producing poly-γ-glutamate (γ-PGA) was newly identified from the rhizosphere soil of Baimiao taro. The strain is a glutamate-independent strain and can produce polyglutamic acid in a culture medium completely free of glutamate. …

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