Dongsheng Wang

Systemic delivery of synapsin‐promoted caveolin‐1 overexpression ameliorates pathological TDP‐43–induced cognitive decline and neurodegenerative changes

Dongsheng Wang, Vinh Ta, H Wang, Jerica Ju et autres

INTRODUCTION: Transactive response DNA-binding protein 43 (TDP-43) proteinopathy is associated with frontotemporal dementia and Alzheimer's disease (AD). We previously demonstrated that synapsin-promoted caveolin-1 (SynCav1) preserves cognitive function in the mouse model of AD. This study investigated the therapeutic potential of SynCav1 in …

us (code pays fourni par la source)

Pilot study of separation surgery with intraoperative radiotherapy (IORT) for spine metastasis

B Liu, Dongsheng Wang, Jian Zhang, Bo Huang et autres

• Modified separation surgery with intraoperative radiotherapy (MSS-IORT) incorporating tumor resection, IORT, bone cement filling, and screw-rod fixation. • MSS-IORT is a feasible and safe treatment option for spine metastasis patients with ESCC ≥ 2 and SINS ≥ 7. • MSS-IORT effectively …

cn (code pays fourni par la source)

TsCA: On the Semantic Consistency Alignment via Conditional Transport for Compositional Zero-Shot Learning

Miaoge Li, Jingcai Guo, Richard Yi Da Xu, Dongsheng Wang et autres

Compositional Zero-Shot Learning (CZSL) aims to recognize novel state-object compositions by leveraging the shared knowledge of their primitive components. Despite considerable progress, effectively calibrating the bias between semantically similar multimodal representations, as well as generalizing pre-trained knowledge to novel compositional contexts, remains …

hk, cn (code pays fourni par la source)

Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models

Dongsheng Wang, Andrei V. Chernov, Ryan Lam, Hongxia Wang et autres

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive synaptic loss and cognitive decline. Gene therapy that augments intrinsic neuroprotective pathways offers a promising strategy to mitigate neurodegeneration and prevent further cognitive loss. Caveolin-1 (Cav-1), a membrane lipid raft (MLR) …

us (code pays fourni par la source)

A Ginsenoside Composition Ameliorated Aβ and Tau Aggregation via Autophagy Lysosome Pathway

Chengmu Zhao, Juan Yue, Yu Ling Xie, Bo Liu et autres

cn (code pays fourni par la source)

Ultrasensitive detection of methamphetamine in environmental water bodies by an Au@carbon dots/chitosan nanocomposite modified electrochemical aptasensor

Chunying Yuan, Mushui Shu, Caini Yang, Ding Ding et autres

cn (code pays fourni par la source)

Genome-wide identification, phylogeny, and expression analysis of PEBP gene family in Castanea mollissima

Yujuan Tian, Jinxin Wang, Xiangyu Wang, Dongsheng Wang et autres

The phosphatidylethanolamine binding protein (PEBP) family plays an important part in growth and development of plants. Castanea mollissima is an economic plant with significant financial value and has become an important food source in the Northern Hemisphere. However, the PEBP genes in …

cn (code pays fourni par la source)

SPECIAL: Phosphorothioate dNTP assisted RPA equipped with CRISPR/Cas12a amplifier enables high-specific nucleic acid testing

Fang Li, Yong Li, Zhong Li, Huan Jiang et autres

cn (code pays fourni par la source)

Temporal responsive vesicle-INFγ aptamer-PEI/HA system targeted activation of B-CD4T-Tfh-CD8T cells cascade inhibits TNBC progression

Qi Liang, Yunbo Luo, Jiao Zeng, Shiqi Han et autres

cn (code pays fourni par la source)

The photosynthetic characteristics and photo-efficiency of 82 Chinese chestnut germplasms

Li Fu, Yong Yang, Jing Liu, Xuan Wang et autres

• We evaluated the photosynthesis-related traits of 82 Chinese chestnut germplasms cultivated in the same environment in order to identify highly photo-efficient varieties. • Regression equations were constructed for each photosynthetic parameter ( Gsw, Tr, PhiPS2, Etr, Gtw ) at different light …

cn (code pays fourni par la source)

Identification and characterization of CmPP2C31 playing a positive role in the abiotic stress resistance of Chinese chestnut via an integrated strategy

Xuan Wang, Wenli Shang, Mingyuan Li, Fei F. Cao et autres

Chinese chestnut ( Castanea mollissima Blume) is an important economic forest tree species and mainly cultivated in mountainous areas and wastelands, subjecting it to various abiotic stresses. The protein phosphatase 2C (PP2C) genes contributes largely to stress responses in plants. However, the …

cn (code pays fourni par la source)

Application of nanozymes in problematic biofilm control: progress, challenges and prospects

Junzheng Zhang, Tong Rui Dou, Yun Fu Shen, Wenrui Wang et autres

cn, us (code pays fourni par la source)