Jun Chen

Perioperative recovery and survival after lobectomy versus sublobar resection in adults aged ≥ 70 years with NSCLC ≤ 3 cm: complementary SEER and real-world cohort analyses

Feng Chen, Haochuan Yu, Wenchao Xia, Fan Ren et autres

For older adults with non-small cell lung cancer (NSCLC), the choice of resection must balance durable cancer control against physiological reserve and postoperative recovery. We combined population-level long-term survival data with granular real-world perioperative data to examine this trade-off. The Surveillance, Epidemiology, …

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Low sRAGE Level is Associated with Increased Future Exacerbation Risk in Mild-to-Moderate COPD and Patients with Chronic Bronchitis Symptoms

Yutian Zhang, Bi Ran, Hao Wang, Dianmei Zhou et autres

Background: Early identification of patients at high-risk for exacerbation in mild-to-moderate chronic obstructive pulmonary disease (COPD), particularly those with chronic bronchitis (CB) phenotype exhibiting worse outcomes, is critical for slowing lung function decline and reducing the subsequent healthcare burden. While the soluble …

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Dietary Moringa oleifera fruit powder improves antioxidant capacity, intestinal development, and gut microbiota in lion-head geese

Lihua Wang, Yichao Yan, Qingyun Cao, Wenjing Chen et autres

< 0.05). In conclusion, dietary supplementation with 4% MOFP effectively enhanced antioxidant capacity, promoted intestinal development, and modulated gut microbiota composition, thereby contributing to improved health status in geese. These findings provide a scientific foundation for the potential application of MOFP as …

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PAD4 deficiency alleviates airway inflammation in a mouse model of COPD exacerbation

Tao Wang, Mengxin Cheng, Yu Wu, Zijian Zeng et autres

Aims: Exacerbations of COPD (ECOPD), characterized by increased airway inflammation and excessive mucus production, negatively impact patient health and accelerate disease progression. Histone citrullination, facilitated by the enzyme peptidylarginine deiminase 4 (PAD4), plays a critical role in the formation of neutrophil extracellular …

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Insight into dispersibility regulation on arsenic removal using magnetic iron oxide nanoparticles

Jun Chen, Jianguo Yu, Sen Lin

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Quasistatic Tensile and Fatigue Performances of Titanium Alloy Open Hole Structures Strengthened by Different Cold Expansion Mandrel Front Cone Angles

Jun Chen, Yuguang Ma, Yangjie Zuo

ABSTRACT In this paper, the cold expansion test of titanium alloy open hole structures was conducted, and the fatigue performance was also assessed. A parametric study of the mandrel front cone angle revealed a correlation with the strengthening quality and fatigue performance …

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Moringa Oleifera Fruit Powder as Metabolic Modulators: Evidence for Enhanced Lipid Metabolism with Controlled Consumption in Geese

Lihua Wang, Yichao Yan, Qingyun Cao, Wenjing Chen et autres

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Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia

Fan Shi, Jun Chen

Type 2 diabetes mellitus accompanied by sarcopenia is an emerging clinical challenge in aging populations, characterized by coexisting metabolic dysfunction and the progressive loss of skeletal muscle mass and function. This comorbidity substantially elevates the risk of frailty, functional impairment, and poor …

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150 Enhancing specificity of gene editing outcomes by using Cas9 variants in swine embryos

Jong‐Hoon Kim, Jung-Ki Yoon, Jun Chen, Han Yong Lee et autres

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife

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Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice

Mengxin Cheng, Yan Xi, Yu Wu, Zijian Zeng et autres

BACKGROUND: Chronic obstructive pulmonary disease (COPD) imposes a significant global health and socioeconomic burden. Exacerbations of COPD (ECOPD), characterized by heightened airway inflammation and mucus hypersecretion, adversely affect patient health and accelerate disease progression. Qingke Pingchuan (QKPC) granules, a formulation from Traditional …

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Advances in CRISPR-based gene editing technology and its application in nucleic acid detection

LiWen Chen, Jia Li, Jun Chen, Lili Duan et autres

Nucleic acid analysis is a key technique that enables accurate detection of various microorganisms. Conventional nucleic acid testing typically requires access to specialized laboratories, equipment, and trained personnel, wh... | Find, read and cite all the research you need on Tech Science …

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Association of T-cell receptor β repertoire diversity and frequent exacerbation phenotype in COPD

Zijian Zeng, Ke Wang, Mengxin Cheng, Yanhui Gu et autres

Aims: Exacerbations of COPD negatively impact health status, rates of hospitalization and readmission, and disease progression in patients. The frequent exacerbation phenotype defined by two or more exacerbations in a given year is a distinct subgroup associated with poorer clinical outcomes. Adaptive …

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