Yu Wang

Ethylene receptors are functionally conserved in calcium permeability across the green lineage

Dongsheng Yu, Chuanli Ju, Changxin Feng, Yu Wang et autres

ABSTRACT The gaseous hormone ethylene plays a key role in regulating plant growth and stress responses. Although Ca²⁺ has long been implicated in ethylene signaling, the identity of molecules controlling Ca²⁺ permeability involved has remained elusive. Here we show that Arabidopsis ethylene …

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Early Prophylactic Anticoagulation and In-Hospital Mortality in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study

Zhao Haodong, Hui Liu, Jiongjiong Cheng, Jia Chen et autres

Purpose: To investigate the association between early prophylactic anticoagulation and in-hospital mortality in ICU patients with severe acute pancreatitis. Patients and Methods: This retrospective cohort study used data from the MIMIC-IV database (v3.1), including adult ICU patients diagnosed with SAP between 2008 …

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Association of MSH2, MSH6, and MLH1 polymorphisms with susceptibility and survival in lung cancer patients

Jing Cheng, Chao Zuo, Dongli Yang, Yi Liu et autres

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Phosphorylation‐dependent activation of MAP4K1/2 by OST1 mediates ABA‐induced stomatal closure in Arabidopsis

Dongxue Tang, Dan Pei, Meixiang Zhang, Xiaoying Hu et autres

ABSTRACT In higher plants, stomatal movements represent a critical physiological process that matains cellular water homestasis while enabling photosynthetic gas exchange. Open stomata 1 (OST1), a key protein kinase in the abscisic acid (ABA) signaling cascade, has been established as a central …

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Synergistic effects of NF-κB1 and inflammatory pathway polymorphisms on hypertension and dyslipidemia susceptibility in type 2 diabetes

Chao Zuo, Jing Cheng, Dongli Yang, Yi Liu et autres

BACKGROUND: Type 2 diabetes mellitus (T2DM) patients exhibit a heightened susceptibility to concurrent hypertension (HTN) and dyslipidemia (DYS), conditions that reciprocally exacerbate cardiovascular risks. This study investigated the association between NF-κB1 polymorphism, related inflammatory mediators, and the predisposition to hypertension and dyslipidemia …

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Astragaloside IV improves the quality of in vitro postovulatory aged oocytes by decreasing oxidative stress in mice

Yueming Wang, Yu Wang, Jinmei Cheng

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Inhibition of Wnt/β-catenin increases anti-tumor activity by synergizing with sorafenib in hepatocellular carcinoma

Yuchao He, Dongming Liu, Aomei Ling, Zhiqiang Han et autres

Hepatocellular carcinoma (HCC) poses a major global health challenge owing to limited treatment efficacy and drug resistance to therapies such as the tyrosine kinase inhibitor (TKI) sorafenib. We utilized a microfluidic three-dimensional (3D) drug testing system to assess drug responses in 37 …

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Nitric oxide delays floral transition in Arabidopsis by inhibiting histone deacetylases HDA5 and HDA6

Wenwen Zhu, Lei Wang, Jinzheng Wang, Ni Zhan et autres

Nitric oxide (NO), a reactive small molecule, plays a critical role in various developmental and physiological processes in living organisms. Previous studies by our group revealed that NO delays flowering in Arabidopsis by increasing transcript levels of the flowering repressor FLOWERING LOCUS …

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Screening and identification of grain sorghum germplasm for salt tolerance at seedling stage

Yu Wang, Dongyang Li, Chunjuan Liu, Xiaolong Shi et autres

Introduction: Sorghum is characterized by its salt tolerance, and holds great potential for cultivation in saline-alkali soils. Methods: This study aimed to comprehensively evaluate the salt tolerance of grain sorghum germplasm. The experiment was conducted with 188 grain sorghum germplasm accessions selected …

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EGFR polymorphisms drive lung cancer risk and survival disparities: a genotype-expression-outcome cohort study

Chao Zuo, Ziqiang Wang, Yi Liu, Jing Cheng et autres

Purpose: To investigate the correlation between single-nucleotide polymorphisms (SNPs) of the Epidermal growth factor receptor (EGFR) gene and its protein expression with susceptibility and survival prognosis of lung cancer (LC) patients. Methods: Using SNP-scan high-throughput technology, the EGFR gene's rs2227983, rs2293347, and …

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ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor

Zhenkai Feng, H.T. Li, Zhihui Sun, Jinkui Cheng et autres

Stomata, which are essential for the exchange of CO 2 and water vapor between plant leaves and the atmosphere, are regulated by a variety of environmental and internal factors. In this study, we identified and characterized two genes, Guard Cell Turgor Maintaining …

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Fam170a deficiency causes male infertility by impairing histone-to-protamine exchange during mouse spermiogenesis

Jinmei Cheng, Yi‐Min Gu, Yueming Wang, jinghui xun et autres

Chromatin remodeling, which involves the histone-to-protamine exchange process during spermiogenesis, is crucial for sperm nuclear condensation and male fertility. However, the key regulators and underlying molecular mechanisms involved in this process remain largely unexplored. In this study, we discovered that deficiency in …

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