Chenxi Li

Porcine TRIM45 negatively regulates the RLR signaling pathway by targeting IKKε for protein degradation

Chenxi Li, Jingjing Li, Shiyu Wang, Ying Liu et autres

cn (code pays fourni par la source)

The 6 bp exon deletion in StMYBA1 affects the expression of genes related to anthocyanin biosynthesis in potato

Xijuan Zhao, Chenxi Li, Shengxuan Liu, Huiling Zhang et autres

Abstract Differential coloration of potato tuber skin is an important agronomic trait. However, its genetic regulatory mechanism remains unclear. In this study, an F₁ segregation population was constructed, and segregation in tuber skin coloration was observed. Using bulked segregant analysis by sequencing …

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Reliable luciferase immunoprecipitation system assays for the detection of porcine reproductive and respiratory syndrome virus antibodies

Tian Tian, Jinyao Guo, Linjie Zhang, Chenxi Li et autres

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SOFA-2 score predicts mortality in pneumonia-associated sepsis: a retrospective cohort study

Shuxing Wei, Tianyu Wang, Chenxi Li, Yuezhi Zhu et autres

BACKGROUND: Pneumonia is the leading cause of sepsis. This study aimed to compare the predictive accuracy for 28-day mortality between Sequential Organ Failure Assessment (SOFA)-2 score and SOFA score in pneumonia-associated sepsis, and to develop and externally validate a composite model incorporating …

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Rational Engineering of a Thermostable Dipeptidase from Thermobrachium celere for Efficient Biosynthesis of l -Carnosine

Xiang-wei Cui, Yuhao Chen, Min-Zhao, Chenxi Li et autres

(TcPepD) was identified and engineered for efficient l-carnosine synthesis. Wild-type TcPepD exhibited an optimal temperature of 70 °C and high thermal stability. Structure-guided mutagenesis based on AlphaFold modeling and molecular docking led to a double mutant, M2 (N117D/I169L), with a 2.7-fold increase …

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Exopolysaccharides from Enterococcus faecium WH strain inhibit porcine epidemic diarrhea virus infection in vitro

Chenxi Li, Xiangchao Jia, Rui Zhou, Zili Li

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Alveolar macrophages initiate the spatially targeted recruitment of neutrophils after nanoparticle inhalation

Qiongliang Liu, Lin Yang, Chenxi Li, Lianyong Han et autres

Lung resident immune cells are essential for initiating defenses against inhaled air pollutants, including nanoparticles (NPs), which contribute to pulmonary disease progression. Here, lung intravital microscopy was used to examine the pulmonary innate immune responses in mice, during acute aerosol exposure to …

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A novel Gaussia luciferase immunoprecipitation assay for the detection of Getah virus antibodies in pigs

Chenxi Li, Linjie Zhang, Jinyao Guo, Chenyang Tang et autres

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Short-term behavioral responses of marine fish to the playback noise from offshore wind turbine operation: A marine medaka study

Haowen Zhang, Chenxi Li, Wenqi Ma, Tieyu Wang et autres

Offshore wind farms integrated with aquaculture optimize ocean space but may impact farmed fish behaviors through noise. This study examined the short-term (10 min) behavioral responses of marine medaka (Oryzias melastigma) to turbine noise using tank-based playback experiments. Three behavioral parameters (i.e., …

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Precise rewiring of corticospinal axons and spinal interneurons via near-infrared optogenetics for spinal cord injury treatment

Yan Jun, Chenxi Li, Yuhui Sun, Shoupeng Wang et autres

To date, precise restoration of proper connections between posttrauma axons and neurons following spinal cord injury (SCI) remains a substantial challenge. Here, we developed glutamate-linked upconversion nanoparticles (Glu-UCNP) to facilitate optogenetic control of axonal sprouting in SCI mice. After being specifically uptaken …

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Therapeutic potential of dihydrocapsaicin in vascular smooth muscle cell calcification

Chenxi Li, Jiajun Chen, Zhiqing Liu, Hongling Zhu et autres

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Porcine MARCH8 negatively regulates the RLR signaling pathway by targeting MAVS for protein degradation

Ying Liu, Jingjing Li, Chenxi Li, Yànhuá Lǐ

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